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作者：Liu, Jingjing; Stoler-Barak, Liat; Hezroni-Bravyi, Hadas; Biram, Adi; Lebon, Sacha; Davidzohn, Natalia; Kedmi, Merav; Chemle, Muriel; Pilzer, David; Cohen, Marina; Brenner, Ori; Biton, Moshe; Shulman, Ziv
作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science
摘要：Nasal vaccination elicits a humoral immune response that provides protection from airborne pathogens(1), yet the origins and specific immune niches of antigen-specific IgA-secreting cells in the upper airways are unclear(2). Here we define nasal glandular acinar structures and the turbinates as immunological niches that recruit IgA-secreting plasma cells from the nasal-associated lymphoid tissues (NALTs)(3). Using intact organ imaging, we demonstrate that nasal vaccination induces B cell expan...
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作者：Bridgewater, Peter; Kim, Rakhyun E.; Blasiak, Robert; Sellheim, Nikolas
作者单位：Australian National University; Utrecht University; Stockholm University
摘要：Almost 80 years after it was created, the international whaling convention has outlived its usefulness. Ending it could set an example for other organizations.
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作者：Gibney, Elizabeth
摘要：US and Chinese firms dominate the list of companies that are producing the most research and patents in artificial intelligence.
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作者：Sitte, Harald H.
作者单位：Medical University of Vienna
摘要：Three studies of the human dopamine transporter reveal how it binds to molecules such as dopamine and cocaine. Dopamine imbalances underlie some brain conditions and these data will aid targeted drug design.
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作者：Tiefel, Anna F.; Grenda, Daniel J.; Allacher, Carina; Harrer, Elias; Nagel, Carolin H.; Kutta, Roger J.; Hernandez-Castillo, David; Narasimhamurthy, Poorva R.; Zeitler, Kirsten; Gonzalez, Leticia; Rehbein, Julia; Nuernberger, Patrick; Breder, Alexander
作者单位：University of Regensburg; University of Regensburg; University of Vienna; University of Vienna; Leipzig University; University of Vienna; University of Regensburg
摘要：The unimolecular heterolysis of covalent sigma-bonds is integral to many chemical transformations, including S(N)1-, E1- and 1,2-migration reactions. To a first approximation, the unequal redistribution of electron density during bond heterolysis is governed by the difference in polarity of the two departing bonding partners(1-3). This means that if a sigma-bond consists of two identical groups (that is, symmetric sigma-bonds), its unimolecular fission from the S-0, S-1, or T-1 states only occ...
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作者：Gong, Cheng; Tian, Hanqin; Liao, Hong; Pan, Naiqing; Pan, Shufen; Ito, Akihiko; Jain, Atul K.; Kou-Giesbrecht, Sian; Joos, Fortunat; Sun, Qing; Shi, Hao; Vuichard, Nicolas; Zhu, Qing; Peng, Changhui; Maggi, Federico; Tang, Fiona H. M.; Zaehle, Sonke
作者单位：Max Planck Society; Boston College; Boston College; Nanjing University of Information Science & Technology; Auburn University System; Auburn University; Boston College; University of Tokyo; National Institute for Environmental Studies - Japan; University of Illinois System; University of Illinois Urbana-Champaign; Dalhousie University; University of Bern; University of Bern; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; CEA; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Quebec; University of Quebec Montreal; Hunan Normal University; University of Sydney; Monash University
摘要：Anthropogenic activities have substantially enhanced the loadings of reactive nitrogen (Nr) in the Earth system since pre-industrial times(1,2), contributing to widespread eutrophication and air pollution(3-6). Increased Nr can also influence global climate through a variety of effects on atmospheric and land processes but the cumulative net climate effect is yet to be unravelled. Here we show that anthropogenic Nr causes a net negative direct radiative forcing of -0.34[-0.20, -0.50]Wm(-2) in ...
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作者：Wang, Ting; Song, Xiaonan; Tan, Jiaxing; Xian, Wei; Zhou, Xingtong; Yu, Mingru; Wang, Xiaofei; Xu, Yan; Wu, Ting; Yuan, Keke; Ran, Yu; Yang, Bing; Fan, Gaofeng; Liu, Xiaoyun; Zhou, Yan; Zhu, Yongqun
作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Peking University; ShanghaiTech University; Zhejiang University
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作者：Gaind, Nisha; Smith, Roff
摘要：By assessing the age of ancient crystals, researchers have traced the monument's greenish Altar Stone to a northern rock basin.
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作者：Ramirez, Sydney I.; Faraji, Farhoud; Hills, L. Benjamin; Lopez, Paul G.; Goodwin, Benjamin; Stacey, Hannah D.; Sutton, Henry J.; Hastie, Kathryn M.; Saphire, Erica Ollmann; Kim, Hyun Jik; Mashoof, Sara; Yan, Carol H.; DeConde, Adam S.; Levi, Gina; Crotty, Shane
作者单位：La Jolla Institute for Immunology; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Seoul National University (SNU)
摘要：The upper airway is an important site of infection, but immune memory in the human upper airway is poorly understood, with implications for COVID-19 and many other human diseases1-4. Here we demonstrate that nasal and nasopharyngeal swabs can be used to obtain insights into these challenging problems, and define distinct immune cell populations, including antigen-specific memory B cells and T cells, in two adjacent anatomical sites in the upper airway. Upper airway immune cell populations seem...
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作者：[Anonymous]
