Protein droplets spread to seal tight junctions

• 成果类型: Editorial Material
• 署名作者: Ludwig, Alexander
• 署名单位: Nanyang Technological University; Nanyang Technological University
• 刊物名称: Nature
• ISSN/ISSBN: 0028-5140
• DOI: 10.1038/d41586-024-02234-7
• 发表日期: 2024-08-07
• 页码: 506-507
• 关键词: phase-separation

摘要

Cells that form tissue barriers rely on cell-cell contacts called tight junctions. These structures assemble from protein condensates that spread along the cell membrane like a water droplet spreading over glass. Step-by-step formation of tight junctions between epithelial cells.