8025期

最新文章

• PYRAMID SCHEME: SIGNS THAT BUILDERS USED HYDRAULICS AI翻译
  作者：[Anonymous]
• Dopamine reuptake and inhibitory mechanisms in human dopamine transporter AI翻译
  作者：Li, Yue; Wang, Xianping; Meng, Yufei; Hu, Tuo; Zhao, Jun; Li, Renjie; Li, Qinru; Yuan, Pu; Han, Jun; Hao, Kun; Wei, Yiqing; Qiu, Yunlong; Li, Na; Zhao, Yan
  作者单位：Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Peking University; Ocean University of China; Capital Medical University; Capital Medical University
  摘要：The dopamine transporter has a crucial role in regulation of dopaminergic neurotransmission by uptake of dopamine into neurons and contributes to the abuse potential of psychomotor stimulants(1-3). Despite decades of study, the structure, substrate binding, conformational transitions and drug-binding poses of human dopamine transporter remain unknown. Here we report structures of the human dopamine transporter in its apo state, and in complex with the substrate dopamine, the attention deficit ...
• Multi-heterojunctioned plastics with high thermoelectric figure of merit AI翻译
  作者：Wang, Dongyang; Ding, Jiamin; Mal, Yingqiao; Xu, Chunlin; Li, Zhiyi; Zhang, Xiao; Zhao, Yao; Zhao, Yue; Di, Yuqiu; Liu, Liyao; Dai, Xiaojuan; Zou, Ye; Kim, BongSoo; Zhang, Fengjiao; Liu, Zitong; McCulloch, Iain; Lee, Myeongjae; Chang, Cheng; Yang, Xiao; Wang, Dong; Zhang, Deqing; Zhao, Li-Dong; Di, Chong-an; Zhu, Daoben
  作者单位：Chinese Academy of Sciences; Institute of Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Tsinghua University; Chinese Academy of Sciences; Institute of Chemistry, CAS; Ulsan National Institute of Science & Technology (UNIST); Lanzhou University; University of Oxford; King Abdullah University of Science & Technology; Korea University; Beihang University; Chinese Academy of Sciences; Institute of Engineering Thermophysics, CAS; Tianmushan Lab
  摘要：Conjugated polymers promise inherently flexible and low-cost thermoelectrics for powering the Internet of Things from waste heat(1,2). Their valuable applications, however, have been hitherto hindered by the low dimensionless figure of merit (ZT)(3-6). Here we report high-ZT thermoelectric plastics, which were achieved by creating a polymeric multi-heterojunction with periodic dual-heterojunction features, where each period is composed of two polymers with a sub-ten-nanometre layered heterojun...
• Innovative way to break chemical bonds broadens horizons for making molecules AI翻译
  作者：Sayre, Hannah J.; Bhatia, Harsh
  作者单位：Northeastern University; Northeastern University
  摘要：A fresh approach to breaking chemical bonds combines the energy of heat and light, and could drive previously inaccessible chemical reactions - opening up synthetic routes to compounds that have not yet been made.
• Tautomeric mixture coordination enables efficient lead-free perovskite LEDs (vol 622, pg 493, 2023) AI翻译
  作者：Han, Dongyuan; Wang, Jie; Agosta, Lorenzo; Zang, Ziang; Zhao, Bin; Kong, Lingmei; Lu, Haizhou; Mosquera-Lois, Irea; Carnevali, Virginia; Dong, Jianchao; Zhou, Jianheng; Ji, Huiyu; Pfeifer, Lukas; Zakeeruddin, Shaik M.; Yang, Yingguo; Wu, Bo; Rothlisberger, Ursula; Yang, Xuyong; Gratzel, Michael; Wang, Ning
  作者单位：Jilin University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Shanghai University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Southeast University - China; Chinese Academy of Sciences; Shanghai Advanced Research Institute, CAS; Zhangjiang Laboratory; Fudan University; South China Normal University; South China Normal University
• Maize smart-canopy architecture enhances yield at high densities AI翻译
  作者：Tian, Jinge; Wang, Chenglong; Chen, Fengyi; Qin, Wenchao; Yang, Hong; Zhao, Sihang; Xia, Jinljang; Du, Xian; Zhu, Yifan; Wu, Lishuan; Cao, Yan; Li, Hong; Zhuang, Junhong; Chen, Shaojiang; Zhang, Huayuan; Chen, Qiuyue; Zhang, Mingcai; Deng, Xing Wang; Deng, Dezhi; Li, Jigang; Tian, Feng
  作者单位：China Agricultural University; Beijing Academy of Agriculture & Forestry Sciences (BAAFS); China Agricultural University; China Agricultural University; China Agricultural University; North Carolina State University; China Agricultural University; Peking University
  摘要：Increasing planting density is a key strategy for enhancing maize yields(1-3). An ideotype for dense planting requires a 'smart canopy' with leaf angles at different canopy layers differentially optimized to maximize light interception and photosynthesis(4-6), among other features. Here we identified leaf angle architecture of smart canopy 1 (lac1), a natural mutant with upright upper leaves, less erect middle leaves and relatively flat lower leaves. lac1 has improved photosynthetic capacity a...
• Molecular mimicry in multisystem inflammatory syndrome in children AI翻译
  作者：Bodansky, Aaron; Mettelman, Robert C.; Sabatino, Joseph J., Jr.; Vazquez, Sara E.; Chou, Janet; Novak, Tanya; Moffitt, Kristin L.; Miller, Haleigh S.; Kung, Andrew F.; Rackaityte, Elze; Zamecnik, Colin R.; Rajan, Jayant, V; Kortbawi, Hannah; Mandel-Brehm, Caleigh; Mitchell, Anthea; Wang, Chung-Yu; Saxena, Aditi; Zorn, Kelsey; Yu, David J. L.; Pogorelyy, Mikhail, V; Awad, Walid; Kirk, Allison M.; Asaki, James; Pluvinage, John, V; Wilson, Michael R.; Zambrano, Laura D.; Campbell, Angela P.; Thomas, Paul G.; Randolph, Adrienne G.; Anderson, Mark S.; DeRisi, Joseph L.
  作者单位：University of California System; University of California San Francisco; St Jude Children's Research Hospital; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI); University of California System; University of California San Francisco; University of California System; University of California San Francisco; Centers for Disease Control & Prevention - USA; Centers for Disease Control & Prevention - USA; University of California System; University of California San Francisco
  摘要：Multisystem inflammatory syndrome in children (MIS-C) is a severe, post-infectious sequela of SARS-CoV-2 infection(1,2), yet the pathophysiological mechanism connecting the infection to the broad inflammatory syndrome remains unknown. Here we leveraged a large set of samples from patients with MIS-C to identify a distinct set of host proteins targeted by patient autoantibodies including a particular autoreactive epitope within SNX8, a protein involved in regulating an antiviral pathway associa...
• 'Publish or Perish' is now a card game - not just an academic's life AI翻译
  作者：Kozlov, Max
  摘要：A player wins by racking up more citations than the competition, even if that means engaging in a little light plagiarism.
• Structure of the human dopamine transporter and mechanisms of inhibition AI翻译
  作者：Srivastava, Dushyant Kumar; Navratna, Vikas; Tosh, Dilip K.; Chinn, Audrey; Sk, Md Fulbabu; Tajkhorshid, Emad; Jacobson, Kenneth A.; Gouaux, Eric
  作者单位：Oregon Health & Science University; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Oregon Health & Science University; Howard Hughes Medical Institute; University of Michigan System; University of Michigan
  摘要：The neurotransmitter dopamine has central roles in mood, appetite, arousal and movement(1). Despite its importance in brain physiology and function, and as a target for illicit and therapeutic drugs, the human dopamine transporter (hDAT) and mechanisms by which it is inhibited by small molecules and Zn2+ are without a high-resolution structural context. Here we determine the structure of hDAT in a tripartite complex with the competitive inhibitor and cocaine analogue, (-)-2-beta-carbomethoxy-3...
• Deep crustal assimilation during the 2021 Fagradalsfjall Fires, Iceland AI翻译
  作者：Day, James M. D.; Kelly, Savannah; Troll, Valentin R.; Moreland, William M.; Cook, Geoffrey W.; Thordarson, Thor
  作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography; Uppsala University; Uppsala University; Centre of Natural Hazards & Disaster Science (CNDS); University of Iceland
  摘要：Active basaltic eruptions enable time-series analysis of geochemical and geophysical properties, providing constraints on mantle composition and eruption processes(1-4). The continuing Fagradalsfjall and Sundhnukur fires on Iceland's Reykjanes Peninsula, beginning in 2021, enable such an approach(5,6). Earliest lavas of this volcanic episode have been interpreted to exclusively reflect a change from shallow to deeper mantle source processes(7). Here we show using osmium (Os) isotopes that the ...