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作者：Ferry, Georgina
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作者：Chuliver, Mariana; Agnolin, Federico L.; Scanferla, Agustin; Rolando, Mauro Aranciaga; Ezcurra, Martin D.; Novas, Fernando E.; Xu, Xing
作者单位：Museo Argentino de Ciencias Naturales Bernardino Rivadavia (MACN); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Museo Argentino de Ciencias Naturales Bernardino Rivadavia (MACN); University of Birmingham; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS
摘要：Anurans are characterized by a biphasic life cycle, with an aquatic larval (tadpole) stage followed by an adult (frog) stage, both connected through the metamorphic period in which drastic morphological and physiological changes occur(1). Extant tadpoles exhibit great morphological diversity and ecological relevance(2), but their absence in the pre-Cretaceous fossil record (older than 145 million years) makes their origins and early evolution enigmatic. This contrasts with the postmetamorphic ...
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作者：Kudiabor, Helena
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作者：Shen, Jiali; Russell, Douglas M.; Devivo, Jenna; Kunkler, Felix; Baalbaki, Rima; Mentler, Bernhard; Scholz, Wiebke; Yu, Wenjuan; Caudillo-Plath, Lucia; Sommer, Eva; Ahongshangbam, Emelda; Alfaouri, Dina; Almeida, Joao; Amorim, Antonio; Beck, Lisa J.; Beckmann, Hannah; Berntheusel, Moritz; Bhattacharyya, Nirvan; Canagaratna, Manjula R.; Chassaing, Anouck; Cruz-Simbron, Romulo; Dada, Lubna; Duplissy, Jonathan; Gordon, Hamish; Granzin, Manuel; Grosse Schute, Lena; Heinritzi, Martin; Iyer, Siddharth; Klebach, Hannah; Krueger, Timm; Kuerten, Andreas; Lampimaeki, Markus; Liu, Lu; Lopez, Brandon; Martinez, Monica; Morawiec, Aleksandra; Onnela, Antti; Peltola, Maija; Rato, Pedro; Reza, Mago; Richter, Sarah; Roerup, Birte; Sebastian, Milin Kaniyodical; Simon, Mario; Surdu, Mihnea; Tamme, Kalju; Thakur, Roseline C.; Tome, Antonio; Tong, Yandong; Top, Jens; Umo, Nsikanabasi Silas; Unfer, Gabriela; Vettikkat, Lejish; Weissbacher, Jakob; Xenofontos, Christos; Yang, Boxing; Zauner-Wieczorek, Marcel; Zhang, Jiangyi; Zheng, Zhensen; Baltensperger, Urs; Christoudias, Theodoros; Flagan, Richard C.; El Haddad, Imad; Junninen, Heikki; Moehler, Ottmar; Riipinen, Ilona; Rohner, Urs; Schobesberger, Siegfried; Volkamer, Rainer; Winkler, Paul M.; Hansel, Armin; Lehtipalo, Katrianne; Donahue, Neil M.; Lelieveld, Jos; Harder, Hartwig; Kulmala, Markku; Worsnop, Doug R.; Kirkby, Jasper; Curtius, Joachim; He, Xu-Cheng
作者单位：University of Helsinki; University of Helsinki; Helsinki Institute of Physics; Goethe University Frankfurt; Carnegie Mellon University; Max Planck Society; University of Innsbruck; European Organization for Nuclear Research (CERN); University of Vienna; University of Helsinki; University of Tartu; Aerodyne Research; Stockholm University; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Tampere University; Carnegie Mellon University; Helmholtz Association; Karlsruhe Institute of Technology; Universidade da Beira Interior; Leibniz Association; Leibniz Institut fur Tropospharenforschung (TROPOS); University of Eastern Finland; California Institute of Technology; TOFWERK AG; Finnish Meteorological Institute; Carnegie Mellon University; Carnegie Mellon University; Nanjing University; Beijing University of Chemical Technology; University of Cambridge
摘要：Aircraft observations have revealed ubiquitous new particle formation in the tropical upper troposphere over the Amazon1,2 and the Atlantic and Pacific oceans3,4. Although the vapours involved remain unknown, recent satellite observations have revealed surprisingly high night-time isoprene mixing ratios of up to 1 part per billion by volume (ppbv) in the tropical upper troposphere5. Here, in experiments performed with the CERN CLOUD (Cosmics Leaving Outdoor Droplets) chamber, we report new par...
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作者：Blum, Steven M.; Zlotoff, Daniel A.; Smith, Neal P.; Kernin, Isabela J.; Ramesh, Swetha; Zubiri, Leyre; Caplin, Joshua; Samanta, Nandini; Martin, Sidney; Wang, Mike; Tirard, Alice; Song, Yuhui; Xu, Katherine H.; Barth, Jaimie; Sen, Pritha; Slowikowski, Kamil; Tantivit, Jessica; Manakongtreecheep, Kasidet; Arnold, Benjamin Y.; Nasrallah, Mazen; Pinto, Christopher J.; Mcloughlin, Daniel; Jackson, Monica; Chan, Puiyee; Lawless, Aleigha; Michaud, William A.; Sharova, Tatyana; Nieman, Linda T.; Gainor, Justin F.; Wu, Catherine J.; Juric, Dejan; Mino-Kenudson, Mari; Oliveira, Giacomo; Sullivan, Ryan J.; Boland, Genevieve M.; Stone, James R.; Thomas, Molly F.; Neilan, Tomas G.; Reynolds, Kerry L.; Villani, Alexandra-Chloe
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Oregon Health & Science University; Oregon Health & Science University
摘要：Immune checkpoint inhibitors are widely used anticancer therapies1 that can cause morbid and potentially fatal immune-related adverse events such as immune-related myocarditis (irMyocarditis)2, 3, 4-5. The pathogenesis of irMyocarditis and its relationship to antitumour immunity remain poorly understood. Here we sought to define immune responses in heart, tumour and blood in patients with irMyocarditis by leveraging single-cell RNA sequencing coupled with T cell receptor (TCR) sequencing, micr...
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作者：Girvan, Paul; Jalal, Adam S. B.; Mccormack, Elizabeth A.; Skehan, Michael T.; Knight, Carol L.; Wigley, Dale B.; Rueda, David S.
作者单位：Imperial College London; Imperial College London
摘要：The yeast SWR1 complex catalyses the exchange of histone H2A-H2B dimers in nucleosomes, with Htz1-H2B dimers1-3. Here we used single-molecule analysis to demonstrate two-step double exchange of the two H2A-H2B dimers in a canonical yeast nucleosome with Htz1-H2B dimers, and showed that double exchange can be processive without release of the nucleosome from the SWR1 complex. Further analysis showed that bound nucleosomes flip between two states, with each presenting a different face, and hence...
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作者：Douglas, Aaron; Stevens, Brenneth; Rendas, Miguel; Kane, Harry; Lynch, Evan; Kunkemoeller, Britta; Wessendorf-Rodriguez, Karl; Day, Emily A.; Sutton, Caroline; Brennan, Martin; O'Brien, Katie; Kohlgruber, Ayano C.; Prendeville, Hannah; Garza, Amanda E.; O'Neill, Luke A. J.; Mills, Kingston H. G.; Metallo, Christian M.; Veiga-Fernandes, Henrique; Lynch, Lydia
作者单位：Trinity College Dublin; Fundacao Champalimaud; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Salk Institute; Princeton University; Princeton University; Ludwig Institute for Cancer Research
摘要：The circadian rhythm of the immune system helps to protect against pathogens(1-3); however, the role of circadian rhythms in immune homeostasis is less well understood. Innate T cells are tissue-resident lymphocytes with key roles in tissue homeostasis(4-7). Here we use single-cell RNA sequencing, a molecular-clock reporter and genetic manipulations to show that innate IL-17-producing T cells-including gamma delta T cells, invariant natural killer T cells and mucosal-associated invariant T cel...
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作者：Love, Alan C.
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
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作者：Pearson, Helen
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作者：Castelvecchi, Davide
