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作者:Reyes, Raphael A.; Raghavan, Sai Sundar Rajan; Hurlburt, Nicholas K.; Introini, Viola; Bol, Sebastiaan; Kana, Ikhlaq Hussain; Jensen, Rasmus W.; Martinez-Scholze, Elizabeth; Gestal-Mato, Maria; Lopez-Gutierrez, Borja; Sanz, Silvia; Bancells, Cristina; Fernandez-Quintero, Monica Lisa; Loeffler, Johannes R.; Ferguson, James Alexander; Lee, Wen-Hsin; Martin, Greg Michael; Theander, Thor G.; Lusingu, John P. A.; Minja, Daniel T. R.; Ssewanyana, Isaac; Feeney, Margaret E.; Greenhouse, Bryan; Ward, Andrew B.; Bernabeu, Maria; Pancera, Marie; Turner, Louise; Bunnik, Evelien M.; Lavstsen, Thomas
作者单位:University of Texas System; University of Texas at San Antonio; University of Copenhagen; Scripps Research Institute; Fred Hutchinson Cancer Center; National Institute of Medical Research; University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要:Malaria pathology is driven by the accumulation of Plasmodium falciparum-infected erythrocytes in microvessels1. This process is mediated by the polymorphic erythrocyte membrane protein 1 (PfEMP1) adhesion proteins of the parasite. A subset of PfEMP1 variants that bind to human endothelial protein C receptor (EPCR) through their CIDR alpha 1 domains is responsible for severe malaria pathogenesis2. A longstanding question is whether individual antibodies can recognize the large repertoire of ci...
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作者:[Anonymous]
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作者:[Anonymous]
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作者:Tan, Qing-Hua; Daddi, Emanuele; Magnelli, Benjamin; Correa, Camila A.; Bournaud, Frederic; Adscheid, Sylvia; Zhang, Shao-Bo; Elbaz, David; Gomez-Guijarro, Carlos; Kalita, Boris S.; Liu, Daizhong; Liu, Zhaoxuan; Pety, Jerome; Puglisi, Annagrazia; Schinnerer, Eva; Silverman, John D.; Valentino, Francesco
作者单位:Purple Mountain Observatory, CAS; Chinese Academy of Sciences; Nanjing Institute of Astronomical Optics & Technology, NAOC, CAS; CEA; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Universite Paris Saclay; University of Bonn; University of Tokyo; University of Tokyo; Peking University; University of Tokyo; Universite PSL; Observatoire de Paris; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); University of Southampton; Durham University; Max Planck Society; Johns Hopkins University; European Southern Observatory
摘要:Most stars in today's Universe reside within spheroids, which are bulges of spiral galaxies and elliptical galaxies1,2. Their formation is still an unsolved problem3, 4-5. Infrared/submillimetre-bright galaxies at high redshifts6 have long been suspected to be related to spheroid formation7, 8, 9, 10, 11-12. Proving this connection has been hampered so far by heavy dust obscuration when focusing on their stellar emission13, 14-15 or by methodologies and limited signal-to-noise ratios when look...
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作者:Swift, Joseph; Luginbuehl, Leonie H.; Hua, Lei; Schreier, Tina B.; Donald, Ruth M.; Stanley, Susan; Wang, Na; Lee, Travis A.; Nery, Joseph R.; Ecker, Joseph R.; Hibberd, Julian M.
作者单位:Salk Institute; University of Cambridge; Salk Institute; Salk Institute; Howard Hughes Medical Institute; University of Oxford
摘要:C4 photosynthesis is used by the most productive plants on the planet, and compared with the ancestral C3 pathway, it confers a 50% increase in efficiency1. In more than 60 C4 lineages, CO2 fixation is compartmentalized between tissues, and bundle-sheath cells become photosynthetically activated2. How the bundle sheath acquires this alternate identity that allows efficient photosynthesis is unclear. Here we show that changes to bundle-sheath gene expression in C4 leaves are associated with the...
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作者:Cook, Kristen L.
作者单位:Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA)
摘要:Climate change and urbanization are exacerbating the effects of flooding. A close look at a Nepalese river reveals that efforts to reduce the impact of floods must consider the geomorphic changes that occur during these extreme events.
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作者:Kudiabor, Helena
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作者:Gao, Teng; Sankaran, Vijay G.
作者单位:Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要:Gene-edited stem cells can be used in regenerative therapies to treat diverse genetic diseases. Tracking the output of these cells over time reveals a commitment to lineages that meet disease-specific needs.
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作者:Binietoglou, Ioannis; Allan, Oscar
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作者:Masood, Ehsan