8041期

最新文章

• A genetic switch drove photosynthesis evolution AI翻译
  作者：Rath, Monalisha; Bergmann, Dominique
  作者单位：Stanford University; Howard Hughes Medical Institute
• Adult skull bone marrow is an expanding and resilient haematopoietic reservoir AI翻译
  作者：Koh, Bong Ihn; Mohanakrishnan, Vishal; Jeong, Hyun-Woo; Park, Hongryeol; Kruse, Kai; Choi, Young Jun; Nieminen-Kelhae, Melina; Kumar, Rahul; Pereira, Raquel S.; Adams, Susanne; Lee, Hyuek Jong; Bixel, M. Gabriele; Vajkoczy, Peter; Krause, Daniela S.; Adams, Ralf H.
  作者单位：Max Planck Society; Max Planck Society; Max Planck Society; University of Ulsan; Asan Medical Center; University of Ulsan; Asan Medical Center; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Johannes Gutenberg University of Mainz; Goethe University Frankfurt; Institute for Basic Science - Korea (IBS)
  摘要：The bone marrow microenvironment is a critical regulator of haematopoietic stem cell self-renewal and fate1. Although it is appreciated that ageing, chronic inflammation and other insults compromise bone marrow function and thereby negatively affect haematopoiesis2, it is not known whether different bone compartments exhibit distinct microenvironmental properties and functional resilience. Here we use imaging, pharmacological approaches and mouse genetics to uncover specialized properties of b...
• A subcortical feeding circuit linking an interoceptive node to jaw movement AI翻译
  作者：Kosse, Christin; Ivanov, Jessica; Knight, Zachary; Pellegrino, Kyle; Friedman, Jeffrey
  作者单位：Rockefeller University; Howard Hughes Medical Institute; University of California System; University of California San Francisco
  摘要：The brain processes an array of stimuli, enabling the selection of appropriate behavioural responses, but the neural pathways linking interoceptive inputs to outputs for feeding are poorly understood1-3. Here we delineate a subcortical circuit in which brain-derived neurotrophic factor (BDNF)-expressing neurons in the ventromedial hypothalamus (VMH) directly connect interoceptive inputs to motor centres, controlling food consumption and jaw movements. VMHBDNF neuron inhibition increases food i...
• OLDEST KNOWN ALPHABET UNEARTHED IN SYRIAN TOMB AI翻译
  作者：Naddaf, Miryam
• ANTARCTIC AMBER DIDN'T FALL FAR FROM THE TREE AI翻译
  作者：[Anonymous]
• The genetic legacy of the wild ancestors of modern cattle AI翻译
  作者：Linderholm, Anna
  作者单位：Stockholm University; Swedish Museum of Natural History
  摘要：Analyses of ancient DNA from aurochs - large, wild cattle that co-existed with humans for millennia - reveals how early humans tamed these beasts and bred them with domesticated cattle for strength and resilience.
• Global potential for natural regeneration in deforested tropical regions AI翻译
  作者：Williams, Brooke A.; Beyer, Hawthorne L.; Fagan, Matthew E.; Chazdon, Robin L.; Schmoeller, Marina; Sprenkle-Hyppolite, Starry; Griscom, Bronson W.; Watson, James E. M.; Tedesco, Anazelia M.; Gonzalez-Roglich, Mariano; Daldegan, Gabriel A.; Bodin, Blaise; Celentano, Danielle; Wilson, Sarah Jane; Rhodes, Jonathan R.; Alexandre, Nikola S.; Kim, Do-Hyung; Bastos, Diego; Crouzeilles, Renato
  作者单位：Queensland University of Technology (QUT); University of Queensland; University of Queensland; University System of Maryland; University of Maryland Baltimore County; University of the Sunshine Coast; Conservation International; Conservation International; University of Victoria; UNICEF
  摘要：Extensive forest restoration is a key strategy to meet nature-based sustainable development goals and provide multiple social and environmental benefits1. Yet achieving forest restoration at scale requires cost-effective methods2. Tree planting in degraded landscapes is a popular but costly forest restoration method that often results in less biodiverse forests when compared to natural regeneration techniques under similar conditions3. Here we assess the current spatial distribution of pantrop...
• Abundant plant gas forms aerosol particles at high altitude - and could affect the climate AI翻译
  作者：Allan, James
  作者单位：UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC National Centre for Atmospheric Science; University of Manchester
• Advising governments about science is essential but difficult. So train people to do it AI翻译
  作者：Oliver, K.
• Differentiation fate of a stem-like CD4 T cell controls immunity to cancer AI翻译
  作者：Cardenas, Maria A.; Prokhnevska, Nataliya; Sobierajska, Ewelina; Gregorova, Petra; Medina, Christopher B.; Valanparambil, Rajesh M.; Greenwald, Rachel; DelBalzo, Luke; Bilen, Mehmet Asim; Joshi, Shreyes; Naryan, Vikram; Master, Viraj A.; Sanda, Martin G.; Kissick, Haydn T.
  作者单位：Emory University; Emory University; Emory University; Emory University; Emory University
  摘要：The T cell response to cancer controls disease progression and response to immunotherapy1-3. Despite extensive knowledge regarding CD8 T cells, how CD4 T cells contribute to this process is less well understood. Here we identified a population of PD1+TCF1+ CD4 T cells with stem-like properties that are capable of self-renewal and differentiation into canonical CD4 effector cells. Primarily residing in tumour-draining lymph nodes (TDLNs), these tumour-specific CD4 T cells are restricted by T re...