作者：Lopez, Victoria Godinez; Valencia-Sanchez, Marco Igor; Abini-Agbomson, Stephen; Thomas, Jonathan F.; Lee, Rachel; De Ioannes, Pablo; Sosa, Brian A.; Armache, Jean-Paul; Armache, Karim-Jean
作者单位：New York University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：Epigenetic inheritance of silent chromatin domains is fundamental to cellular memory during embryogenesis, but it must overcome the dilution of repressive histone modifications during DNA replication1. One such modification, histone H2A lysine 119 monoubiquitination (H2AK119Ub), needs to be re-established by the Polycomb repressive complex 1 (PRC1) E3 ligase to restore the silent Polycomb domain2,3. However, the exact mechanism behind this restoration remains unknown. Here, combining cryo-elec...
作者：Peik, Ekkehard; Kharas, Kaitlin; Chunlai, Li; Abalkina, Anna; Xu, Huji; Yunus, Muhammad; Mbala, Placide; Bahr, Cordelia; Lam, Remi; Freedman, Wendy
摘要：A fraud buster, a nuclear-clock maker and a virus hunter. These are just a few of the remarkable people chosen for this year's Nature's 10.
