作者:Fowle-Grider, Ronald; Rowles, Joe L.; Shen, Isabel; Wang, Yahui; Schwaiger-Haber, Michaela; Dunham, Alden J.; Jayachandran, Kay; Inkman, Matthew; Zahner, Michael; Naser, Fuad J.; Jackstadt, Madelyn M.; Spalding, Jonathan L.; Chiang, Sarah; Mccommis, Kyle S.; Dolle, Roland E.; Kramer, Eva T.; Zimmerman, Sarah M.; Souroullas, George P.; Finck, Brian N.; Shriver, Leah P.; Kaufman, Charles K.; Schwarz, Julie K.; Zhang, Jin; Patti, Gary J.
作者单位:Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Saint Louis University; Siteman Cancer Center; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
摘要:Fructose consumption has increased considerably over the past five decades, largely due to the widespread use of high-fructose corn syrup as a sweetener1. It has been proposed that fructose promotes the growth of some tumours directly by serving as a fuel2,3. Here we show that fructose supplementation enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer without causing weight gain or insulin resistance. The cancer cells themselves were unable to use fructose r...
作者:Blanchard, Joel W.; Akay, Leyla Anne; Davila-Velderrain, Jose; von Maydell, Djuna; Mathys, Hansruedi; Davidson, Shawn M.; Effenberger, Audrey; Chen, Chih-Yu; Maner-Smith, Kristal; Hajjar, Ihab; Ortlund, Eric A.; Bula, Michael; Agbas, Emre; Ng, Ayesha; Jiang, Xueqiao; Kahn, Martin; Blanco-Duque, Cristina; Lavoie, Nicolas; Liu, Liwang; Reyes, Ricardo; Lin, Yuan-Ta; Ko, Tak; R'Bibo, Lea; Ralvenius, William T.; Bennett, David A.; Cam, Hugh P.; Kellis, Manolis; Tsai, Li-Huei
作者:Birch, Max T.; Belopolski, Ilya; Fujishiro, Yukako; Kawamura, Minoru; Kikkawa, Akiko; Taguchi, Yasujiro; Hirschberger, Max; Nagaosa, Naoto; Tokura, Yoshinori