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作者：Eisfeld, Amie J.; Biswas, Asim; Guan, Lizheng; Gu, Chunyang; Maemura, Tadashi; Trifkovic, Sanja; Wang, Tong; Babujee, Lavanya; Dahn, Randall; Halfmann, Peter J.; Barnhardt, Tera; Neumann, Gabriele; Suzuki, Yasuo; Thompson, Alexis; Swinford, Amy K.; Dimitrov, Kiril M.; Poulsen, Keith; Kawaoka, Yoshihiro
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Shizuoka; Texas A&M University System; Texas A&M University College Station; University of Wisconsin System; University of Wisconsin Madison; University of Tokyo; University of Tokyo
摘要：Highly pathogenic H5N1 avian influenza (HPAI H5N1) viruses occasionally infect, but typically do not transmit, in mammals. In the spring of 2024, an unprecedented outbreak of HPAI H5N1 in bovine herds occurred in the USA, with virus spread within and between herds, infections in poultry and cats, and spillover into humans, collectively indicating an increased public health risk1-4. Here we characterize an HPAI H5N1 virus isolated from infected cow milk in mice and ferrets. Like other HPAI H5N1...
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作者：Berube, Benjamin; Ernst, Evan; Cahn, Jonathan; Roche, Benjamin; de Santis Alves, Cristiane; Lynn, Jason; Scheben, Armin; Grimanelli, Daniel; Siepel, Adam; Ross-Ibarra, Jeffrey; Kermicle, Jerry; Martienssen, Robert A.
作者单位：Howard Hughes Medical Institute; Cold Spring Harbor Laboratory; Cold Spring Harbor Laboratory; Universite de Montpellier; University of California System; University of California Davis; University of Wisconsin System; University of Wisconsin Madison
摘要：Selfish genetic elements contribute to hybrid incompatibility and bias or 'drive' their own transmission(1,2). Chromosomal drive typically functions in asymmetric female meiosis, whereas gene drive is normally post-meiotic and typically found in males. Here, using single-molecule and single-pollen genome sequencing, we describe Teosinte Pollen Drive, an instance of gene drive in hybrids between maize (Zea mays ssp. mays) and teosinte mexicana (Z. mays ssp. mexicana) that depends on RNA interfe...
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作者：Pyle, Charlie J.; Tobin, David M.
摘要：Authors in the 1920s and 1970s had different takes on how science would shape the future. Nature's reviewers had similarly diverse views on how accurate these predictions would be.
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作者：Furutachi, Shohei; Franklin, Alexis D.; Aldea, Andreea M.; Mrsic-Flogel, Thomas D.; Hofer, Sonja B.
作者单位：University of London; University College London
摘要：The brain functions as a prediction machine, utilizing an internal model of the world to anticipate sensations and the outcomes of our actions. Discrepancies between expected and actual events, referred to as prediction errors, are leveraged to update the internal model and guide our attention towards unexpected events1-10. Despite the importance of prediction-error signals for various neural computations across the brain, surprisingly little is known about the neural circuit mechanisms respon...
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作者：[Anonymous]
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作者：Angello, Nicholas H.; Friday, David M.; Hwang, Changhyun; Yi, Seungjoo; Cheng, Austin H.; Torres-Flores, Tiara C.; Jira, Edward R.; Wang, Wesley; Aspuru-Guzik, Alan; Burke, Martin D.; Schroeder, Charles M.; Diao, Ying; Jackson, Nicholas E.
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Toronto; Vector Institute for Artificial Intelligence; University of Toronto; Canadian Institute for Advanced Research (CIFAR); University of Toronto; University of Toronto; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Artificial intelligence-guided closed-loop experimentation has emerged as a promising method for optimization of objective functions1,2, but the substantial potential of this traditionally black-box approach to uncovering new chemical knowledge has remained largely untapped. Here we report the integration of closed-loop experiments with physics-based feature selection and supervised learning, denoted as closed-loop transfer (CLT), to yield chemical insights in parallel with optimization of obj...
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作者：Marshall, Lindsay; Simmons, Rebecca; Sower, Greg
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作者：Paladini, Claudia
作者单位：European Southern Observatory
摘要：A powerful telescope array has imaged the surface of a star called R Doradus. The observations will help astronomers to understand the fluid dynamics of evolved giant stars - a type of star that the Sun will eventually become.
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作者：Cheng, Tianhe; Liu, Zhenzhen; Li, Haiming; Huang, Xiaorong; Wang, Wei; Shi, Ce; Zhang, Xuecheng; Chen, Hong; Yao, Zhuang; Zhao, Peng; Peng, Xiongbo; Sun, Meng-Xiang
作者单位：Wuhan University; Xiamen University
摘要：Fertilization introduces parental genetic information into the zygote to guide embryogenesis. Parental contributions to postfertilization development have been discussed for decades, and the data available show that both parents contribute to the zygotic transcriptome, suggesting a paternal role in early embryogenesis1-6. However, because the specific paternal effects on postfertilization development and the molecular pathways underpinning these effects remain poorly understood, paternal contr...
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作者：Wagner, Jonathan; Carvajal, Alonso I.; Bracher, Andreas; Beck, Florian; Wan, William; Bohn, Stefan; Koerner, Roman; Baumeister, Wolfgang; Fernandez-Busnadiego, Ruben; Hartl, F. Ulrich
作者单位：Max Planck Society; Max Planck Society; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Gottingen; Max Planck Society; Vanderbilt University; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; University of Gottingen
摘要：Chaperonins are large barrel-shaped complexes that mediate ATP-dependent protein folding(1-3). The bacterial chaperonin GroEL forms juxtaposed rings that bind unfolded protein and the lid-shaped cofactor GroES at their apertures. In vitro analyses of the chaperonin reaction have shown that substrate protein folds, unimpaired by aggregation, while transiently encapsulated in the GroEL central cavity by GroES(4-6). To determine the functional stoichiometry of GroEL, GroES and client protein in s...
