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作者：Ji, Wenming; Miao, Anran; Liang, Kai; Liu, Jiameng; Qi, Yuhan; Zhou, Yue; Duan, Xinli; Sun, Jixue; Lai, Lipeng; Wu, Jing-Xiang
作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College
摘要：Norepinephrine transporter (NET; encoded by SLC6A2) reuptakes the majority of the released noradrenaline back to the presynaptic terminals, thereby affecting the synaptic noradrenaline level1. Genetic mutations and dysregulation of NET are associated with a spectrum of neurological conditions in humans, making NET an important therapeutic target1. However, the structure and mechanism of NET remain unclear. Here we provide cryogenic electron microscopy structures of the human NET (hNET) in thre...
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作者：Malamud, Mariano; Whitehead, Lauren; Mcintosh, Alasdair; Colella, Fabio; Roelofs, Anke J.; Kusakabe, Takato; Dambuza, Ivy M.; Phillips-Brookes, Annie; Salazar, Fabian; Perez, Federico; Shoesmith, Romey; Zakrzewski, Przemyslaw; Sey, Emily A.; Rodrigues, Cecilia; Morvay, Petruta L.; Redelinghuys, Pierre; Bedekovic, Tina; Fernandes, Maria J. G.; Almizraq, Ruqayyah; Branch, Donald R.; Amulic, Borko; Harvey, Jamie; Stewart, Diane; Yuecel, Raif; Reid, Delyth M.; Mcconnachie, Alex; Pickering, Matthew C.; Botto, Marina; Iliev, Iliyan D.; McInnes, Iain B.; De Bari, Cosimo; Willment, Janet A.; Brown, Gordon D.
作者单位：University of Exeter; University of Aberdeen; University of Glasgow; University of Aberdeen; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; University of Toronto; Hospital for Sick Children (SickKids); University of Bristol; Laval University; Canadian Blood Services; University of Exeter; Imperial College London
摘要：Regulation of neutrophil activation is critical for disease control. Neutrophil extracellular traps (NETs), which are web-like structures composed of DNA and neutrophil-derived proteins, are formed following pro-inflammatory signals; however, if this process is uncontrolled, NETs contribute to disease pathogenesis, exacerbating inflammation and host tissue damage1,2. Here we show that myeloid inhibitory C-type lectin-like (MICL), an inhibitory C-type lectin receptor, directly recognizes DNA in...
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作者：van der Linden, Sander
作者单位：University of Cambridge
摘要：The engagement-fuelled logic of social media has bequeathed us a world in which what's trending is a yardstick for what's true.
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作者：Eren, A. Murat; Delmont, Tom O.
作者单位：Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; Carl von Ossietzky Universitat Oldenburg; Marine Biological Laboratory - Woods Hole; Max Planck Society; CEA; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS)
摘要：The direct recovery of microbial genomes from complex environments is now routine. Going from environmental genomes to laboratory experiments is rare, but the tide is turning.
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作者：Marshall, Lindsay; Simmons, Rebecca; Sower, Greg
摘要：Letter to the Editor
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作者：Pyle, Charlie J.; Tobin, David M.
作者单位：Duke University; Duke University
摘要：The immune-signalling protein TNF has an essential role in inflammatory responses. Two people who were found to have no functional TNF are surprisingly healthy and able to fend off most infections, but are susceptible to tuberculosis.
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作者：[Anonymous]
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作者：Reardon, Sara
摘要：The disease has a consistent mark in the brain even when symptoms are absent.
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作者：Chen, Jianwei; Jia, Yangyang; Sun, Ying; Liu, Kun; Zhou, Changhao; Liu, Chuan; Li, Denghui; Liu, Guilin; Zhang, Chengsong; Yang, Tao; Huang, Lei; Zhuang, Yunyun; Wang, Dazhi; Xu, Dayou; Zhong, Qiaoling; Guo, Yang; Li, Anduo; Seim, Inge; Jiang, Ling; Wang, Lushan; Lee, Simon Ming Yuen; Liu, Yujing; Wang, Dantong; Zhang, Guoqiang; Liu, Shanshan; Wei, Xiaofeng; Yue, Zhen; Zheng, Shanmin; Shen, Xuechun; Wang, Sen; Qi, Chen; Chen, Jing; Ye, Chen; Zhao, Fang; Wang, Jun; Fan, Jie; Li, Baitao; Sun, Jiahui; Jia, Xiaodong; Xia, Zhangyong; Zhang, He; Liu, Junnian; Zheng, Yue; Liu, Xin; Wang, Jian; Yang, Huanming; Kristiansen, Karsten; Xu, Xun; Mock, Thomas; Li, Shengying; Zhang, Wenwei; Fan, Guangyi
作者单位：Beijing Genomics Institute (BGI); University of Copenhagen; Shandong University; Beijing Genomics Institute (BGI); Ocean University of China; Xiamen University; Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Deep-Sea Science & Engineering, CAS; Nanjing Tech University; Hong Kong Polytechnic University; Hong Kong Polytechnic University; Beijing Genomics Institute (BGI); University of East Anglia
摘要：The past two decades has witnessed a remarkable increase in the number of microbial genomes retrieved from marine systems1,2. However, it has remained challenging to translate this marine genomic diversity into biotechnological and biomedical applications3,4. Here we recovered 43,191 bacterial and archaeal genomes from publicly available marine metagenomes, encompassing a wide range of diversity with 138 distinct phyla, redefining the upper limit of marine bacterial genome size and revealing c...
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作者：Liu, Cheng; Yang, Yi; Chen, Hao; Spanopoulos, Ioannis; Bati, Abdulaziz S. R.; Gilley, Isaiah W.; Chen, Jianhua; Maxwell, Aidan; Vishal, Badri; Reynolds, Robert P.; Wiggins, Taylor E.; Wang, Zaiwei; Huang, Chuying; Fletcher, Jared; Liu, Yuan; Chen, Lin X.; De Wolf, Stefaan; Chen, Bin; Zheng, Ding; Marks, Tobin J.; Facchetti, Antonio; Sargent, Edward H.; Kanatzidis, Mercouri G.
作者单位：Northwestern University; State University System of Florida; University of South Florida; University of Toronto; King Abdullah University of Science & Technology; Northwestern University; University System of Georgia; Georgia Institute of Technology
摘要：Two-dimensional (2D) and three-dimensional (3D) perovskite heterostructures have played a key role in advancing the performance of perovskite solar cells1,2. However, the migration of cations between 2D and 3D layers results in the disruption of octahedral networks, leading to degradation in performance over time3,4. We hypothesized that perovskitoids, with robust organic-inorganic networks enabled by edge- and face-sharing, could impede ion migration. We explored a set of perovskitoids of var...
