People who lack the immune protein TNF can still fight infection

• 成果类型: News Item
• 署名作者: Pyle, Charlie J.; Tobin, David M.
• 署名单位: Duke University; Duke University
• 刊物名称: Nature
• ISSN/ISSBN: 0028-6118
• DOI: 10.1038/d41586-024-02657-2
• 发表日期: 2024-09-12
• 页码: 293-294
• 关键词: mycobacterium-tuberculosis infection; necrosis-factor-alpha; tumor; disease

摘要

The immune-signalling protein TNF has an essential role in inflammatory responses. Two people who were found to have no functional TNF are surprisingly healthy and able to fend off most infections, but are susceptible to tuberculosis.