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作者：Dunn, Michael E.; Kithcart, Aaron; Kim, Jee Hae; Ho, Andre Jo-Hao; Franklin, Matthew C.; Romero Hernandez, Annabel; de Hoon, Jan; Botermans, Wouter; Meyer, Jonathan; Jin, Ximei; Zhang, Dongqin; Torello, Justin; Jasewicz, Daniel; Kamat, Vishal; Garnova, Elena; Liu, Nina; Rosconi, Michael; Pan, Hao; Karnik, Satyajit; Burczynski, Michael E.; Zheng, Wenjun; Rafique, Ashique; Nielsen, Jonas B.; De, Tanima; Verweij, Niek; Pandit, Anita; Locke, Adam; Chalasani, Naga; Melander, Olle; Schwantes-An, Tae-Hwi; Biobank, Penn Medicine; Baras, Aris; Lotta, Luca A.; Musser, Bret J.; Mastaitis, Jason; Devalaraja-Narashimha, Kishor B.; Rankin, Andrew J.; Huang, Tammy; Herman, Gary; Olson, William; Murphy, Andrew J.; Yancopoulos, George D.; Olenchock, Benjamin A.; Morton, Lori
作者单位：Regeneron; KU Leuven; University Hospital Leuven; Regeneron; Indiana University System; Indiana University Bloomington; Indiana University Health; IU Health University Hospital; Lund University; Lund University; Skane University Hospital; Indiana University System; Indiana University Bloomington
摘要：Heart failure is a leading cause of morbidity and mortality 1,2 . Elevated intracardiac pressures and myocyte stretch in heart failure trigger the release of counter-regulatory natriuretic peptides, which act through their receptor (NPR1) to affect vasodilation, diuresis and natriuresis, lowering venous pressures and relieving venous congestion 3-8 . Recombinant natriuretic peptide infusions were developed to treat heart failure but have been limited by a short duration of effect 9,10 . Here w...
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作者：Mifsud, Jonathon C. O.; Lytras, Spyros; Oliver, Michael R.; Toon, Kamilla; Costa, Vincenzo A.; Holmes, Edward C.; Grove, Joe
作者单位：University of Sydney; University of Glasgow; University of Tokyo
摘要：Viral glycoproteins drive membrane fusion in enveloped viruses and determine host range, tissue tropism and pathogenesis(1). Despite their importance, there is a fragmentary understanding of glycoproteins within the Flaviviridae(2), a large virus family that include pathogens such as hepatitis C, dengue and Zika viruses, and numerous other human, animal and emergent viruses. For many flaviviruses the glycoproteins have not yet been identified, for others, such as the hepaciviruses, the molecul...
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作者：Gaind, Nisha
摘要：It was modelled after DARPA, the hugely successful US tech funder. Can Britain's Advanced Research and Invention Agency - ARIA - create revolutionary innovations?
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作者：Lee, Juyeun; Lathia, Justin D.
摘要：The human brain is usually considered to be beyond the reach of most immune cells. However, analysis of people who have brain tumours has revealed tumour-targeting T cells of the immune system in skull bones near the cancer site.
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作者：Forrester, Terrence
作者单位：University West Indies Mona Jamaica
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作者：Mallapaty, Smriti
摘要：The Pathoplexus database has sequences from Ebola, West Nile virus and another dangerous pathogen.
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作者：Oei, Martijn S. S. L.; Hardcastle, Martin J.; Timmerman, Roland; Gast, Aivin R. D. J. G. I. B.; Botteon, Andrea; Rodriguez, Antonio C.; Stern, Daniel; Calistro Rivera, Gabriela; van Weeren, Reinout J.; Roettgering, Huub J. A.; Intema, Huib T.; de Gasperin, Francesco; Djorgovski, S. G.
作者单位：Leiden University; Leiden University - Excl LUMC; California Institute of Technology; University of Hertfordshire; Durham University; University of Oxford; Istituto Nazionale Astrofisica (INAF); California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); European Southern Observatory; Helmholtz Association; German Aerospace Centre (DLR)
摘要：When sustained for megayears (refs. 1,2), high-power jets from supermassive black holes (SMBHs) become the largest galaxy-made structures in the Universe3. By pumping electrons, atomic nuclei and magnetic fields into the intergalactic medium (IGM), these energetic flows affect the distribution of matter and magnetism in the cosmic web4-6 and could have a sweeping cosmological influence if they reached far at early epochs. For the past 50 years, the known size range of black hole jet pairs ende...
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作者：Lentzsch, Alfred M.; Yudin, Denis; Gamerdinger, Martin; Chandrasekar, Sowmya; Rabl, Laurenz; Scaiola, Alain; Deuerling, Elke; Ban, Nenad; Shan, Shu-ou
作者单位：California Institute of Technology; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Konstanz
摘要：Approximately 40% of the mammalian proteome undergoes N-terminal methionine excision and acetylation, mediated sequentially by methionine aminopeptidase (MetAP) and N-acetyltransferase A (NatA), respectively(1). Both modifications are strictly cotranslational and essential in higher eukaryotic organisms(1). The interaction, activity and regulation of these enzymes on translating ribosomes are poorly understood. Here we perform biochemical, structural and in vivo studies to demonstrate that the...
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作者：Soliman, Alix
摘要：Telling people about the consensus among scientists can help, study finds, but researchers think that personal conversations are needed, too.
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作者：Shah, Hiral; Olivetta, Marine; Bhickta, Chandni; Ronchi, Paolo; Trupinic, Monika; Tromer, Eelco C.; Tolic, Iva M.; Schwab, Yannick; Dudin, Omaya; Dey, Gautam
