2024

最新文章

• Isolation of a methyl-reducing methanogen outside the Euryarchaeota (vol 632, pg 1124, 2024) AI翻译
  作者：Wu, Kejia; Zhou, Lei; Tahon, Guillaume; Liu, Laiyan; Li, Jiang; Zhang, Jianchao; Zheng, Fengfeng; Deng, Chengpeng; Han, Wenhao; Bai, Liping; Fu, Lin; Dong, Xiuzhu; Zhang, Chuanlun; Ettema, Thijs J. G.; Sousa, Diana Z.; Cheng, Lei
• A step towards protein sequencing by pores AI翻译
  作者：Aksimentiev, Aleksei
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Biologists would love to be able to read out the amino-acid sequence of any protein molecule as they would the letters of a sentence. A system in which a biological motor pulls proteins through a pore brings the dream closer to reality.
• Decoding drivers of carbon flux attenuation in the oceanic biological pump AI翻译
  作者：Bressac, M.; Laurenceau-Cornec, E. C.; Kennedy, F.; Santoro, A. E.; Paul, N. L.; Briggs, N.; Carvalho, F.; Boyd, P. W.
  作者单位：Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); University of Tasmania; University of California System; University of California Santa Barbara; NERC National Oceanography Centre; University of Southampton; Centre National de la Recherche Scientifique (CNRS); Ifremer; Institut de Recherche pour le Developpement (IRD); Universite de Bretagne Occidentale; Institut Universitaire Europeen de la Mer (IUEM)
  摘要：The biological pump supplies carbon to the oceans' interior, driving long-term carbon sequestration and providing energy for deep-sea ecosystems1,2. Its efficiency is set by transformations of newly formed particles in the euphotic zone, followed by vertical flux attenuation via mesopelagic processes3. Depth attenuation of the particulate organic carbon (POC) flux is modulated by multiple processes involving zooplankton and/or microbes4,5. Nevertheless, it continues to be mainly parameterized ...
• Doctors cured her sickle-cell disease. So why is she still in pain? AI翻译
  作者：Ledford, Heidi
• Two-dimensional-lattice-confined single-molecule-like aggregates AI翻译
  作者：Wang, Kang; Lin, Zih-Yu; De, Angana; Kocoj, Conrad A.; Shao, Wenhao; Yang, Hanjun; He, Zehua; Coffey, Aidan H.; Fruhling, Colton B.; Tang, Yuanhao; Varadharajan, Dharini; Zhu, Chenhui; Zhao, Yong Sheng; Boltasseva, Alexandra; Shalaev, Vladimir M.; Guo, Peijun; Savoie, Brett M.; Dou, Letian
  作者单位：Purdue University System; Purdue University; Chinese Academy of Sciences; Institute of Chemistry, CAS; Purdue University System; Purdue University; Yale University; Yale University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Purdue University System; Purdue University; Purdue University System; Purdue University
  摘要：Intermolecular distance largely determines the optoelectronic properties of organic matter. Conventional organic luminescent molecules are commonly used either as aggregates or as single molecules that are diluted in a foreigner matrix. They have garnered great research interest in recent decades for a variety of applications, including light-emitting diodes1,2, lasers3-5 and quantum technologies6,7, among others8-10. However, there is still a knowledge gap on how these molecules behave betwee...
• Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells (vol 627, pg 646, 2024) AI翻译
  作者：Guan, Xiangnan; Hu, Ruozhen; Choi, Yoonha; Srivats, Shyam; Nabet, Barzin Y.; Silva, John; Mcginnis, Lisa; Hendricks, Robert; Nutsch, Katherine; Banta, Karl L.; Duong, Ellen; Dunkle, Alexis; Chang, Patrick S.; Han, Chia-Jung; Mittman, Stephanie; Molden, Nandini; Daggumati, Pallavi; Connolly, Wendy; Johnson, Melissa; Abreu, Delvys Rodriguez; Cho, Byoung Chul; Italiano, Antoine; Gil-Bazo, Ignacio; Felip, Enriqueta; Mellman, Ira; Mariathasan, Sanjeev; Shames, David S.; Meng, Raymond; Chiang, Eugene Y.; Johnston, Robert J.; Patil, Namrata S.
• Growth of complete ammonia oxidizers on guanidine AI翻译
  作者：Palatinszky, Marton; Herbold, Craig W.; Sedlacek, Christopher J.; Puehringer, Dominic; Kitzinger, Katharina; Giguere, Andrew T.; Wasmund, Kenneth; Nielsen, Per H.; Dueholm, Morten K. D.; Jehmlich, Nico; Gruseck, Richard; Legin, Anton; Kostan, Julius; Krasnici, Nesrete; Schreiner, Claudia; Palmetzhofer, Johanna; Hofmann, Thilo; Zumstein, Michael; Djinovic-Carugo, Kristina; Daims, Holger; Wagner, Michael
  作者单位：University of Vienna; University of Vienna; Medical University of Vienna; University of Vienna; Vienna Biocenter (VBC); Max F. Perutz Laboratories (MFPL); Aalborg University; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); University of Vienna; University of Vienna; University of Vienna; European Molecular Biology Laboratory (EMBL); University of Canterbury; University of Portsmouth
  摘要：Guanidine is a chemically stable nitrogen compound that is excreted in human urine and is widely used in manufacturing of plastics, as a flame retardant and as a component of propellants, and is well known as a protein denaturant in biochemistry1-3. Guanidine occurs widely in nature and is used by several microorganisms as a nitrogen source, but microorganisms growing on guanidine as the only substrate have not yet been identified. Here we show that the complete ammonia oxidizer (comammox) Nit...
• AI model collapse might be prevented by studying human language transmission AI翻译
  作者：Smith, Kenny; Kirby, Simon; Guo, Shangmin; Griffiths, Thomas L.
  作者单位：University of Edinburgh; Princeton University
• Multi-pass, single-molecule nanopore reading of long protein strands AI翻译
  作者：Motone, Keisuke; Kontogiorgos-Heintz, Daphne; Wee, Jasmine; Kurihara, Kyoko; Yang, Sangbeom; Roote, Gwendolin; Fox, Oren E.; Fang, Yishu; Queen, Melissa; Tolhurst, Mattias; Cardozo, Nicolas; Jain, Miten; Nivala, Jeff
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Northeastern University; University of Osaka
  摘要：The ability to sequence single protein molecules in their native, full-length form would enable a more comprehensive understanding of proteomic diversity. Current technologies, however, are limited in achieving this goal1,2. Here, we establish a method for the long-range, single-molecule reading of intact protein strands on a commercial nanopore sensor array. By using the ClpX unfoldase to ratchet proteins through a CsgG nanopore3,4, we provide single-molecule evidence that ClpX translocates s...
• Titration of RAS alters senescent state and influences tumour initiation AI翻译
  作者：Chan, Adelyne S. L.; Zhu, Haoran; Narita, Masako; Cassidy, Liam D.; Young, Andrew R. J.; Bermejo-Rodriguez, Camino; Janowska, Aleksandra T.; Chen, Hung-Chang; Gough, Sarah; Oshimori, Naoki; Zender, Lars; Aitken, Sarah J.; Hoare, Matthew; Narita, Masashi
  作者单位：CRUK Cambridge Institute; University of Cambridge; Cancer Research UK; University of Liverpool; Oregon Health & Science University; Eberhard Karls University of Tubingen; Eberhard Karls University Hospital; Helmholtz Association; German Cancer Research Center (DKFZ); Eberhard Karls University of Tubingen; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; Institute of Science Tokyo; Tokyo Institute of Technology
  摘要：Oncogenic RAS-induced senescence (OIS) is an autonomous tumour suppressor mechanism associated with premalignancy1,2. Achieving this phenotype typically requires a high level of oncogenic stress, yet the phenotype provoked by lower oncogenic dosage remains unclear. Here we develop oncogenic RAS dose-escalation models in vitro and in vivo, revealing a RAS dose-driven non-linear continuum of downstream phenotypes. In a hepatocyte OIS model in vivo, ectopic expression of NRAS(G12V) does not induc...