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作者：[Anonymous]
摘要：Online safety is crucial, but so are privacy and decentralization. Computer scientists who set the Internet's technical standards should be included in governance talks. Online safety is crucial, but so are privacy and decentralization. Computer scientists who set the Internet's technical standards should be included in governance talks.
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作者：[Anonymous]
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作者：Moore, Logan D.; Amuwa, Toluwanimi Chris; Shaw, Scott Richard; Ballinger, Matthew J.
作者单位：Mississippi State University; University of Wyoming
摘要：Parasitoid wasps are exceptionally diverse and use specialized adaptations capable of manipulating the physiology and behaviour of host organisms(1). In more than two centuries since the first records of Drosophila-parasitizing wasps, nearly 200 described and provisional parasitoid species of drosophilids have been identified(2). These include endoparasitoids and ectoparasitoids, as well as species attacking larval and pupal hosts(3). Despite a deep history of research attention and remarkable...
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作者：Byrne, Brendan; Liu, Junjie; Bowman, Kevin W.; Pascolini-Campbell, Madeleine; Chatterjee, Abhishek; Pandey, Sudhanshu; Miyazaki, Kazuyuki; van der Werf, Guido R.; Wunch, Debra; Wennberg, Paul O.; Roehl, Coleen M.; Sinha, Saptarshi
作者单位：California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; University of California System; University of California Los Angeles; Wageningen University & Research; University of Toronto; California Institute of Technology; Washington University (WUSTL)
摘要：The 2023 Canadian forest fires have been extreme in scale and intensity with more than seven times the average annual area burned compared to the previous four decades1. Here, we quantify the carbon emissions from these fires from May to September 2023 on the basis of inverse modelling of satellite carbon monoxide observations. We find that the magnitude of the carbon emissions is 647 TgC (570-727 TgC), comparable to the annual fossil fuel emissions of large nations, with only India, China and...
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作者：Beddows, Cait A.; Shi, Feiyue; Horton, Anna L.; Dalal, Sagar; Zhang, Ping; Ling, Chang-Chun; Yong, V. Wee; Loh, Kim; Cho, Ellie; Karagiannis, Chris; Rose, Adam J.; Montgomery, Magdalene K.; Gregorevic, Paul; Watt, Matthew J.; Packer, Nicolle H.; Parker, Benjamin L.; Brown, Robyn M.; Moh, Edward S. X.; Dodd, Garron T.
作者单位：University of Melbourne; University of Melbourne; University of Melbourne; Florey Institute of Neuroscience & Mental Health; Macquarie University; ARC Centre of Excellence in Synthetic Biology; University of Calgary; University of Calgary; University of Calgary; St. Vincent's Institute of Medical Research; University of Melbourne; University of Melbourne; Monash University; University of Washington; University of Washington Seattle
摘要：Metabolic diseases such as obesity and type 2 diabetes are marked by insulin resistance(1,2). Cells within the arcuate nucleus of the hypothalamus (ARC), which are crucial for regulating metabolism, become insulin resistant during the progression of metabolic disease(3-8), but these mechanisms are not fully understood. Here we investigated the role of a specialized chondroitin sulfate proteoglycan extracellular matrix, termed a perineuronal net, which surrounds ARC neurons. In metabolic diseas...
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作者：Zheng, Xiao-Feng; Sarkar, Aniruddha; Lotana, Humphrey; Syed, Aleem; Nguyen, Huy; Ivey, Richard G.; Kennedy, Jacob J.; Whiteaker, Jeffrey R.; Tomasik, Bartlomiej; Huang, Kaimeng; Li, Feng; DAndrea, Alan D.; Paulovich, Amanda G.; Shah, Kavita; Spektor, Alexander; Chowdhury, Dipanjan
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Purdue University System; Purdue University; Purdue University System; Purdue University; Fred Hutchinson Cancer Center; Medical University Lodz; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Fahrenheit Universities; Medical University Gdansk
摘要：CDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression1. Here we demonstrate that CDK5 is active during mitosis and is necessary for maintaining mitotic fidelity. CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p392. Here, using independent chemical genetic approaches, we specifically abrogated CDK5 activity during mitosis, and observed mitotic defects, nuclear...
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作者：Kozlov, Max
摘要：A mechanism for metabolic disease is traced to a defective cellular scaffolding that holds together the brain's hunger cells. A mechanism for metabolic disease is traced to a defective cellular scaffolding that holds together the brain's hunger cells.
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作者：Zhao, Jie; Yue, Chao; Wang, Jiaming; Hantson, Stijn; Wang, Xianli; He, Binbin; Li, Guangyao; Wang, Liang; Zhao, Hongfei; Luyssaert, Sebastiaan
作者单位：Northwest A&F University - China; Linyi University; Northwest A&F University - China; Northwest A&F University - China; Northwest A&F University - China; Universidad del Rosario; Natural Resources Canada; Canadian Forest Service; University of Electronic Science & Technology of China; Vrije Universiteit Amsterdam
摘要：Climate warming has caused a widespread increase in extreme fire weather, making forest fires longer-lived and larger1-3. The average forest fire size in Canada, the USA and Australia has doubled or even tripled in recent decades4,5. In return, forest fires feed back to climate by modulating land-atmospheric carbon, nitrogen, aerosol, energy and water fluxes6-8. However, the surface climate impacts of increasingly large fires and their implications for land management remain to be established....
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作者：Imada, Shinya; Khawaled, Saleh; Shin, Heaji; Meckelmann, Sven W.; Whittaker, Charles A.; Correa, Renan Oliveira; Alquati, Chiara; Lu, Yixin; Tie, Guodong; Pradhan, Dikshant; Calibasi-Kocal, Gizem; Melo, Luiza Martins Nascentes; Allies, Gabriele; Roesler, Jonas; Wittenhofer, Pia; Krystkiewicz, Jonathan; Schmitz, Oliver J.; Roper, Jatin; Vinolo, Marco Aurelio Ramirez; Ricciardiello, Luigi; Lien, Evan C.; Vander Heiden, Matthew G.; Shivdasani, Ramesh A.; Cheng, Chia-Wei; Tasdogan, Alpaslan; Yilmaz, Oemer H.
作者单位：Massachusetts Institute of Technology (MIT); University of Duisburg Essen; Massachusetts Institute of Technology (MIT); Universidade de Sao Paulo; Universidade Estadual de Campinas; Universidade Estadual de Campinas; University of Bologna; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Dokuz Eylul University; University of Duisburg Essen; Helmholtz Association; German Cancer Research Center (DKFZ); Duke University; Duke University; University of Texas System; UTMD Anderson Cancer Center; Van Andel Institute; Columbia University; NewYork-Presbyterian Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Massachusetts General Hospital; Harvard University; Harvard Medical School
摘要：For over a century, fasting regimens have improved health, lifespan and tissue regeneration in diverse organisms, including humans1-6. However, how fasting and post-fast refeeding affect adult stem cells and tumour formation has yet to be explored in depth. Here we demonstrate that post-fast refeeding increases intestinal stem cell (ISC) proliferation and tumour formation; post-fast refeeding augments the regenerative capacity of Lgr5+ ISCs, and loss of the tumour suppressor gene Apc in post-f...
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作者：Tacon, Dave
摘要：Rebecca Hsu works as a forest ecologist for the Taiwan Forestry Institute in Taipei.
