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作者：Clarke, Catriona
摘要：A levitating frog, a necrophiliac duck, taxi drivers' brains - the Ig Nobel prizes have shined a spotlight on offbeat work. Here's an inside look at how winners feel about this sometimes unwanted 'honour'.
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作者：Sippel, Sebastian; Kent, Elizabeth C.; Meinshausen, Nicolai; Chan, Duo; Kadow, Christopher; Neukom, Raphael; Fischer, Erich M.; Humphrey, Vincent; Rohde, Robert; de Vries, Iris; Knutti, Reto
作者单位：Leipzig University; Swiss Federal Institutes of Technology Domain; ETH Zurich; NERC National Oceanography Centre; Swiss Federal Institutes of Technology Domain; ETH Zurich; NERC National Oceanography Centre; University of Southampton; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Federal Office of Meteorology & Climatology (MeteoSwiss)
摘要：The observed temperature record, which combines sea surface temperatures with near-surface air temperatures over land, is crucial for understanding climate variability and change1-4. However, early records of global mean surface temperature are uncertain owing to changes in measurement technology and practice, partial documentation5-8, and incomplete spatial coverage9. Here we show that existing estimates of ocean temperatures in the early twentieth century (1900-1930) are too cold, based on i...
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作者：Li, Changqing; Smirnova, Ekaterina; Schnitzler, Charlotte; Crucifix, Corinne; Concordet, Jean Paul; Brion, Alice; Poterszman, Arnaud; Schultz, Patrick; Papai, Gabor; Ben-Shem, Adam
作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC)
摘要：Chromatin structure is a key regulator of DNA transcription, replication and repair1. In humans, the TIP60-EP400 complex (TIP60-C) is a 20-subunit assembly that affects chromatin structure through two enzymatic activities: ATP-dependent exchange of histone H2A-H2B for H2A.Z-H2B, and histone acetylation. In yeast, however, these activities are performed by two independent complexes-SWR1 and NuA4, respectively2,3. How the activities of the two complexes are merged into one supercomplex in humans...
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作者：Ryu, Keun Woo; Fung, Tak Shun; Baker, Daphne C.; Saoi, Michelle; Park, Jinsung; Febres-Aldana, Christopher A.; Aly, Rania G.; Cui, Ruobing; Sharma, Anurag; Fu, Yi; Jones, Olivia L.; Cai, Xin; Pasolli, H. Amalia; Cross, Justin R.; Rudin, Charles M.; Thompson, Craig B.
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Rockefeller University; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center
摘要：Mitochondria serve a crucial role in cell growth and proliferation by supporting both ATP synthesis and the production of macromolecular precursors. Whereas oxidative phosphorylation (OXPHOS) depends mainly on the oxidation of intermediates from the tricarboxylic acid cycle, the mitochondrial production of proline and ornithine relies on reductive synthesis1. How these competing metabolic pathways take place in the same organelle is not clear. Here we show that when cellular dependence on OXPH...
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作者：Xia, Yiyu; Han, Zhongdong; Watanabe, Kenji; Taniguchi, Takashi; Shan, Jie; Mak, Kin Fai
作者单位：Cornell University; Cornell University; National Institute for Materials Science
摘要：Moir & eacute; materials have enabled the realization of flat electron bands and quantum phases that are driven by the strong correlations associated with flat bands1-4. Superconductivity has been observed, but only in graphene moir & eacute; materials5-9. The absence of robust superconductivity in moir & eacute; materials beyond graphene, such as semiconductor moir & eacute; materials4, has remained a mystery and challenged our current understanding of superconductivity in flat bands. Here we...
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作者：Peskin, Sara Manning
作者单位：University of Pennsylvania
摘要：A captivating examination of the biology that underlies behaviours often considered immoral raises questions about the existence of free will.
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作者：To, Ken; Fei, Lijiang; Pett, J. Patrick; Roberts, Kenny; Blain, Raphael; Polanski, Krzysztof; Li, Tong; Yayon, Nadav; He, Peng; Xu, Chuan; Cranley, James; Moy, Madelyn; Li, Ruoyan; Kanemaru, Kazumasa; Huang, Ni; Megas, Stathis; Richardson, Laura; Kapuge, Rakesh; Perera, Shani L.; Tuck, Elizabeth; Wilbrey-Clark, Anna; Mulas, Ilaria; Memi, Fani; Cakir, Batuhan; Predeus, Alexander, V; Horsfall, David; Murray, Simon; Prete, Martin; Mazin, Pavel; He, Xiaoling; Meyer, Kerstin B.; Haniffe, Muzlifah; Barker, Roger A.; Bayraktar, Omer; Chedotal, Alain; Buckley, Christopher D.; Teichmanns, Sarah A.
作者单位：Wellcome Trust Sanger Institute; University of Cambridge; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; University of California System; University of California San Francisco; University of Cambridge; University of Cambridge; University of Cambridge; Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle University - UK; Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; CHU Lyon; Universite Claude Bernard Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); University of Oxford; Kennedy Institute for Rheumatology; Canadian Institute for Advanced Research (CIFAR)
摘要：Human embryonic bone and joint formation is determined by coordinated differentiation of progenitors in the nascent skeleton. The cell states, epigenetic processes and key regulatory factors that underlie lineage commitment of these cells remain elusive. Here we applied paired transcriptional and epigenetic profiling of approximately 336,000 nucleus droplets and spatial transcriptomics to establish a multi-omic atlas of human embryonic joint and cranium development between 5 and 11 weeks after...
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作者：Liu, Jiang; He, Yongcai; Ding, Lei; Zhang, Hua; Li, Qiaoyan; Jia, Lingbo; Yu, Jia; Lau, Ting Wai; Li, Minghui; Qin, Yuan; Gu, Xiaobing; Zhang, Fu; Li, Qibo; Yang, Ying; Zhao, Shuangshuang; Wu, Xiaoyong; Liu, Jie; Liu, Tong; Gao, Yajun; Wang, Yonglei; Dong, Xin; Chen, Hao; Li, Ping; Zhou, Tianxiang; Yang, Miao; Ru, Xiaoning; Peng, Fuguo; Yin, Shi; Qu, Minghao; Zhao, Dongming; Zhao, Zhiguo; Li, Menglei; Guo, Penghui; Yan, Hui; Xiao, Chuanxiao; Xiao, Ping; Yin, Jun; Zhang, Xiaohong; Li, Zhenguo; He, Bo; Xu, Xixiang
作者单位：Soochow University - China; Soochow University - China; Hong Kong Polytechnic University; Chinese Academy of Sciences; Ningbo Institute of Materials Technology & Engineering, CAS; Xi'an Jiaotong University; Beijing University of Technology
摘要：Two-terminal monolithic perovskite/silicon tandem solar cells demonstrate huge advantages in power conversion efficiency compared with their respective single-junction counterparts1,2. However, suppressing interfacial recombination at the wide-bandgap perovskite/electron transport layer interface, without compromising its superior charge transport performance, remains a substantial challenge for perovskite/silicon tandem cells3,4. By exploiting the nanoscale discretely distributed lithium fluo...
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作者：Gibney, Elizabeth
摘要：Nanosecond-precision measurements from mobile devices could fill in gaps in satellite-navigation systems.
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作者：Yayon, Nadav; Kedlian, Veronika R.; Boehme, Lena; Suo, Chenqu; Wachter, Brianna T.; Beuschel, Rebecca T.; Amsalem, Oren; Polanski, Krzysztof; Koplev, Simon; Tuck, Elizabeth; Dann, Emma; Van Hulle, Jolien; Perera, Shani; Putteman, Tom; Predeus, Alexander V.; Dabrowska, Monika; Richardson, Laura; Tudor, Catherine; Kreins, Alexandra Y.; Engelbert, Justin; Stephenson, Emily; Kleshchevnikov, Vitalii; De Rita, Fabrizio; Crossland, David; Bosticardo, Marita; Pala, Francesca; Prigmore, Elena; Chipampe, Nana-Jane; Prete, Martin; Fei, Lijiang; To, Ken; Barker, Roger A.; He, Xiaoling; Van Nieuwerburgh, Filip; Bayraktar, Omer Ali; Patel, Minal; Davies, E. Graham; Haniffa, Muzlifah A.; Uhlmann, Virginie; Notarangelo, Luigi D.; Germain, Ronald N.; Radtke, Andrea J.; Marioni, John C.; Taghon, Tom; Teichmann, Sarah A.
作者单位：Wellcome Trust Sanger Institute; European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; Ghent University; University of Cambridge; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Division of Intramural Research (DIR); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; University of London; University College London; Great Ormond Street Hospital for Children NHS Foundation Trust; University of London; University College London; Newcastle University - UK; Newcastle University - UK; Newcastle Freeman Hospital; University of Cambridge; University of Cambridge; Ghent University; Ghent University; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle University - UK; CRUK Cambridge Institute; University of Cambridge; Cancer Research UK; University of Cambridge
摘要：T cells develop from circulating precursor cells, which enter the thymus and migrate through specialized subcompartments that support their maturation and selection1. In humans, this process starts in early fetal development and is highly active until thymic involution in adolescence. To map the microanatomical underpinnings of this process in pre- and early postnatal stages, we established a quantitative morphological framework for the thymus-the Cortico-Medullary Axis-and used it to perform ...
