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作者：Poletayev, Andrey D.; Hoffmann, Matthias C.; Dawson, James A.; Teitelbaum, Samuel W.; Trigo, Mariano; Islam, M. Saiful; Lindenberg, Aaron M.
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作者：Gibney, Elizabeth; Castelvecchi, Davide
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作者：Marchant, Jo
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作者：Fan, Weiguo; Adebowale, Kolade; Vancza, Lorand; Li, Yuan; Rabbi, Md Foysal; Kunimoto, Koshi; Chen, Dongning; Mozes, Gergely; Chiu, David Kung-Chun; Li, Yisi; Tao, Junyan; Wei, Yi; Adeniji, Nia; Brunsing, Ryan L.; Dhanasekaran, Renumathy; Singhi, Aatur; Geller, David; Lo, Su Hao; Hodgson, Louis; Engleman, Edgar G.; Charville, Gregory W.; Charu, Vivek; Monga, Satdarshan P.; Kim, Taeyoon; Wells, Rebecca G.; Chaudhuri, Ovijit; Torok, Natalie J.
作者单位：Stanford University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Palo Alto Health Care System; Stanford University; Stanford University; Purdue University System; Purdue University; Stanford University; Stanford University; Tsinghua University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Stanford University; University of California System; University of California Davis; Yeshiva University; Stanford University; Keio University; University of Pennsylvania; Stanford University
摘要：Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development1,2, and increased stiffness is known to promote HCC progression in cirrhotic conditions3,4. Type 2 diabetes mellitus is characterized by an accumulation of advanced glycation end-products (AGEs) in the ECM; however, how this affects HCC in non-cirrhotic conditions is unclear. Here we find that, in patients and animal models, AGEs p...
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作者：Li, Hongjie; Nakajima, Yoshiki; Nango, Eriko; Owada, Shigeki; Yamada, Daichi; Hashimoto, Kana; Luo, Fangjia; Tanaka, Rie; Akita, Fusamichi; Kato, Koji; Kang, Jungmin; Saitoh, Yasunori; Kishi, Shunpei; Yu, Huaxin; Matsubara, Naoki; Fujii, Hajime; Sugahara, Michihiro; Suzuki, Mamoru; Masuda, Tetsuya; Kimura, Tetsunari; Thao, Tran Nguyen; Yonekura, Shinichiro; Yu, Long-Jiang; Tosha, Takehiko; Tono, Kensuke; Joti, Yasumasa; Hatsui, Takaki; Yabashi, Makina; Kubo, Minoru; Iwata, So; Isobe, Hiroshi; Yamaguchi, Kizashi; Suga, Michihiro; Shen, Jian-Ren
作者单位：Okayama University; Tohoku University; RIKEN; Japan Synchrotron Radiation Research Institute; University of Hyogo; Kyoto University; University of Osaka; Ryukoku University; Kobe University; Chinese Academy of Sciences; Institute of Botany, CAS; University of Osaka
摘要：Photosystem II (PSII) catalyses the oxidation of water through a four-step cycle of S-i states (i=0-4) at the Mn4CaO5 cluster(1-3), during which an extra oxygen (O6) is incorporated at the S-3 state to form a possible dioxygen(4-7). Structural changes of the metal cluster and its environment during the S-state transitions have been studied on the microsecond timescale. Here we use pump-probe serial femtosecond crystallography to reveal the structural dynamics of PSII from nanoseconds to millis...
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作者：Bhowmick, Asmit; Hussein, Rana; Bogacz, Isabel; Simon, Philipp S.; Ibrahim, Mohamed; Chatterjee, Ruchira; Doyle, Margaret D.; Cheah, Mun Hon; Fransson, Thomas; Chernev, Petko; Kim, In-Sik; Makita, Hiroki; Dasgupta, Medhanjali; Kaminsky, Corey J.; Zhang, Miao; Gaetcke, Julia; Haupt, Stephanie; Nangca, Isabela I.; Keable, Stephen M.; Aydin, A. Orkun; Tono, Kensuke; Owada, Shigeki; Gee, Leland B.; Fuller, Franklin D.; Batyuk, Alexander; Alonso-Mori, Roberto; Holton, James M.; Paley, Daniel W.; Moriarty, Nigel W.; Mamedov, Fikret; Adams, Paul D.; Brewster, Aaron S.; Dobbek, Holger; Sauter, Nicholas K.; Bergmann, Uwe; Zouni, Athina; Messinger, Johannes; Kern, Jan; Yano, Junko; Yachandra, Vittal K.
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作者：Xu, Muqing; Kendrick, Lev Haldar; Kale, Anant; Gang, Youqi; Ji, Geoffrey; Scalettar, Richard T.; Lebrat, Martin; Greiner, Markus
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作者：Krempasky, J.; Smejkal, L.; D'Souza, S. W.; Hajlaoui, M.; Springholz, G.; Uhlirova, K.; Alarab, F.; Constantinou, P. C.; Strocov, V.; Usanov, D.; Pudelko, W. R.; Gonzalez-Hernandez, R.; Hellenes, A. Birk; Jansa, Z.; Reichlova, H.; Soban, Z.; Betancourt, R. D. Gonzalez; Wadley, P.; Sinova, J.; Kriegner, D.; Minar, J.; Dil, J. H.; Jungwirth, T.
作者单位：Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Johannes Gutenberg University of Mainz; Czech Academy of Sciences; Institute of Physics of the Czech Academy of Sciences; University of West Bohemia Pilsen; Johannes Kepler University Linz; Charles University Prague; University of Zurich; Universidad del Norte Colombia; University of Nottingham; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
摘要：Lifted Kramers spin degeneracy (LKSD) has been among the central topics of condensed-matter physics since the dawn of the band theory of solids(1,2). It underpins established practical applications as well as current frontier research, ranging from magnetic-memory technology(3-7) to topological quantum matter(8-14). Traditionally, LKSD has been considered to originate from two possible internal symmetry-breaking mechanisms. The first refers to time-reversal symmetry breaking by magnetization o...
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作者：[Anonymous]
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作者：Zhang, Mingmin; Wu, Ye Emily; Jiang, Mengping; Hong, Weizhe
作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles
摘要：Humans and animals exhibit various forms of prosocial helping behaviour towards others in need1-3. Although previous research has investigated how individuals may perceive others' states4,5, the neural mechanisms of how they respond to others' needs and goals with helping behaviour remain largely unknown. Here we show that mice engage in a form of helping behaviour towards other individuals experiencing physical pain and injury-they exhibit allolicking (social licking) behaviour specifically t...
