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作者：Okubo, Takumi; Rivron, Nicolas; Kabata, Mio; Masaki, Hideki; Kishimoto, Keiko; Semi, Katsunori; Nakajima-Koyama, May; Kunitomi, Haruko; Kaswandy, Belinda; Sato, Hideyuki; Nakauchi, Hiromitsu; Woltjen, Knut; Saitou, Mitinori; Sasaki, Erika; Yamamoto, Takuya; Takashima, Yasuhiro
作者单位：Kyoto University; Austrian Academy of Sciences; Vienna Biocenter (VBC); Institute of Molecular Biotechnology (IMBA); University of Tokyo; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); Stanford University; Kyoto University; Kyoto University; RIKEN
摘要：Recently, several studies using cultures of human embryos together with single-cell RNA-seq analyses have revealed differences between humans and mice, necessitating the study of human embryos1-8. Despite the importance of human embryology, ethical and legal restrictions have limited post-implantation-stage studies. Thus, recent efforts have focused on developing in vitro self-organizing models using human stem cells9-17. Here, we report genetic and non-genetic approaches to generate authentic...
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作者：McMahan, Katherine; Wegmann, Frank; Aid, Malika; Sciacca, Michaela; Liu, Jinyan; Hachmann, Nicole P.; Miller, Jessica; Jacob-Dolan, Catherine; Powers, Olivia; Hope, David; Wu, Cindy; Pereira, Juliana; Murdza, Tetyana; Mazurek, Camille R.; Hoyt, Amelia; Boon, Adrianus C. M.; Davis-Gardner, Meredith; Suthar, Mehul S.; Martinot, Amanda J.; Boursiquot, Mona; Cook, Anthony; Pessaint, Laurent; Lewis, Mark G.; Andersen, Hanne; Tolboom, Jeroen; Serroyen, Jan; Solforosi, Laura; Costes, Lea M. M.; Zahn, Roland C.; Barouch, Dan H.
作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Ragon Institute; Washington University (WUSTL); Emory University; Tufts University; BIOQUAL Inc.
摘要：A limitation of current SARS-CoV-2 vaccines is that they provide minimal protection against infection with current Omicron subvariants1,2, although they still provide protection against severe disease. Enhanced mucosal immunity may be required to block infection and onward transmission. Intranasal administration of current vaccines has proven inconsistent3-7, suggesting that alternative immunization strategies may be required. Here we show that intratracheal boosting with a bivalent Ad26-based...
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作者：Tibbs, Taylor
作者单位：University of North Carolina; University of North Carolina Chapel Hill
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作者：Tollefson, Jeff
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作者：Zhang, Ketao; Chermprayong, Pisak; Xiao, Feng; Tzoumanikas, Dimos; Dams, Barrie; Kay, Sebastian; Kocer, Basaran Bahadir; Burns, Alec; Orr, Lachlan; Alhinai, Talib; Choi, Christopher; Darekar, Durgesh Dattatray; Li, Wenbin; Hirschmann, Steven; Soana, Valentina; Ngah, Shamsiah Awang; Grillot, Clement; Sareh, Sina; Choubey, Ashutosh; Margheri, Laura; Pawar, Vijay M.; Ball, Richard J.; Williams, Chris; Shepherd, Paul; Leutenegger, Stefan; Stuart-Smith, Robert; Kovac, Mirko
作者单位：Imperial College London; University of London; Queen Mary University London; Imperial College London; University of Bath; University of London; University College London; Technical University of Munich; University of Pennsylvania; Swiss Federal Institutes of Technology Domain; Swiss Federal Laboratories for Materials Science & Technology (EMPA)
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作者：Zhang, Wenbo; Sayavong, Philaphon; Xiao, Xin; Oyakhire, Solomon T.; Shuchi, Sanzeeda Baig; Vila, Rafael A.; Boyle, David T.; Kim, Sang Cheol; Kim, Mun Sek; Holmes, Sarah E.; Ye, Yusheng; Li, Donglin; Bent, Stacey F.; Cui, Yi
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory
摘要：Rechargeable Li-metal batteries have the potential to more than double the specific energy of the state-of-the-art rechargeable Li-ion batteries, making Li-metal batteries a prime candidate for next-generation high-energy battery technology1-3. However, current Li-metal batteries suffer from fast cycle degradation compared with their Li-ion battery counterparts2,3, preventing their practical adoption. A main contributor to capacity degradation is the disconnection of Li from the electrochemica...
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作者：Kachale, Ambar; Pavlikova, Zuzana; Nenarokova, Anna; Roithova, Adriana; Durante, Ignacio M.; Miletinova, Petra; Zahonova, Kristina; Nenarokov, Serafim; Votypka, Jan; Horakova, Eva; Ross, Robert L.; Yurchenko, Vyacheslav; Beznoskova, Petra; Paris, Zdenek; Valasek, Leos Shivaya; Lukes, Julius
作者单位：Czech Academy of Sciences; Biology Centre of the Czech Academy of Sciences; University of South Bohemia Ceske Budejovice; Czech Academy of Sciences; Institute of Microbiology of the Czech Academy of Sciences; Charles University Prague; University of Ostrava; Thermo Fisher Scientific; University of Bristol; Czech Academy of Sciences; Institute of Microbiology of the Czech Academy of Sciences
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作者：Castelvecchi, Davide
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作者：Hislop, Joshua; Song, Qi; Keshavarz, F. Kamyar; Alavi, Amir; Schoenberger, Rayna; Legraw, Ryan; Velazquez, Jeremy J.; Mokhtari, Tahere; Taheri, Mohammad Naser; Rytel, Matthew; Chuva de Sousa Lopes, Susana M.; Watkins, Simon; Stolz, Donna; Kiani, Samira; Sozen, Berna; Bar-Joseph, Ziv; Ebrahimkhani, Mo R.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Carnegie Mellon University; Carnegie Mellon University; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Yale University
摘要：Implantation of the human embryo begins a critical developmental stage that comprises profound events including axis formation, gastrulation and the emergence of haematopoietic system1,2. Our mechanistic knowledge of this window of human life remains limited due to restricted access to in vivo samples for both technical and ethical reasons3-5. Stem cell models of human embryo have emerged to help unlock the mysteries of this stage6-16. Here we present a genetically inducible stem cell-derived ...
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作者：Wu, Di; Chen, Qihao; Yu, Zhuoya; Huang, Bo; Zhao, Jun; Wang, Yuhang; Su, Jiawei; Zhou, Feng; Yan, Rui; Li, Na; Zhao, Yan; Jiang, Daohua
作者单位：Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Biophysics, CAS; Peking University; Capital Medical University; Capital Medical University; Songshan Lake Materials Laboratory
摘要：Vesicular monoamine transporter 2 (VMAT2) accumulates monoamines in presynaptic vesicles for storage and exocytotic release, and has a vital role in monoaminergic neurotransmission1-3. Dysfunction of monoaminergic systems causes many neurological and psychiatric disorders, including Parkinson's disease, hyperkinetic movement disorders and depression4-6. Suppressing VMAT2 with reserpine and tetrabenazine alleviates symptoms of hypertension and Huntington's disease7,8, respectively. Here we desc...
