Cortical regulation of helping behaviour towards others in pain

• 成果类型: Article
• 署名作者: Zhang, Mingmin; Wu, Ye Emily; Jiang, Mengping; Hong, Weizhe
• 署名单位: University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles
• 刊物名称: Nature
• ISSN/ISSBN: 0028-5195
• DOI: 10.1038/s41586-023-06973-x
• 发表日期: 2024-02-15
• 关键词: escherichia-coli chromosome; cell-cycle; messenger-rna; gene-expression; dna-replication; global analysis; division cycle; copy number; transcription; proteins

摘要

Humans and animals exhibit various forms of prosocial helping behaviour towards others in need1-3. Although previous research has investigated how individuals may perceive others' states4,5, the neural mechanisms of how they respond to others' needs and goals with helping behaviour remain largely unknown. Here we show that mice engage in a form of helping behaviour towards other individuals experiencing physical pain and injury-they exhibit allolicking (social licking) behaviour specifically towards the injury site, which aids the recipients in coping with pain. Using microendoscopic imaging, we found that single-neuron and ensemble activity in the anterior cingulate cortex (ACC) encodes others' state of pain and that this representation is different from that of general stress in others. Furthermore, functional manipulations demonstrate a causal role of the ACC in bidirectionally controlling targeted allolicking. Notably, this behaviour is represented in a population code in the ACC that differs from that of general allogrooming, a distinct type of prosocial behaviour elicited by others' emotional stress. These findings advance our understanding of the neural coding and regulation of helping behaviour. A study describes the role of the anterior cingulate cortex in coding and regulating helping behaviour exhibited by mice towards others experiencing pain.