Roll-to-roll, high-resolution 3D printing of shape-specific particles

• 成果类型: Article
• 署名作者: Kronenfeld, Jason M.; Rother, Lukas; Saccone, Max A.; Dulay, Maria T.; DeSimone, Joseph M.
• 署名单位: Stanford University; Stanford University; Stanford University
• 刊物名称: Nature
• ISSN/ISSBN: 0028-4302
• DOI: 10.1038/s41586-024-07061-4
• 发表日期: 2024-03-14
• 关键词: long-term-memory; continuous-flow lithography; fear memory; messenger-rna; amygdala; delivery; bdnf; fabrication; size; nanoparticles

摘要

Particle fabrication has attracted recent attention owing to its diverse applications in bioengineering1,2, drug and vaccine delivery3-5, microfluidics6,7, granular systems8,9, self-assembly5,10,11, microelectronics12,13 and abrasives14. Herein we introduce a scalable, high-resolution, 3D printing technique for the fabrication of shape-specific particles based on roll-to-roll continuous liquid interface production (r2rCLIP). We demonstrate r2rCLIP using single-digit, micron-resolution optics in combination with a continuous roll of film (in lieu of a static platform), enabling the rapidly permutable fabrication and harvesting of shape-specific particles from a variety of materials and with complex geometries, including geometries not possible to achieve with advanced mould-based techniques. We demonstrate r2rCLIP production of mouldable and non-mouldable shapes with voxel sizes as small as 2.0 x 2.0 mu m2 in the print plane and 1.1 +/- 0.3 mu m unsupported thickness, at speeds of up to 1,000,000 particles per day. Such microscopic particles with permutable, intricate designs enable direct integration within biomedical, analytical and advanced materials applications. We introduce a scalable, high-resolution, 3D printing technique for the fabrication of shape-specific particles based on roll-to-roll continuous liquid interface production, enabling direct integration within biomedical, analytical and advanced materials applications.