2024

最新文章

• SUPERCOLLIDER SNEAKS PEEK AT A PARTICLE TRIO AI翻译
  作者：[Anonymous]
• Global supply chains amplify economic costs of future extreme heat risk AI翻译
  作者：Sun, Yida; Zhu, Shupeng; Wang, Daoping; Duan, Jianping; Lu, Hui; Yin, Hao; Tan, Chang; Zhang, Lingrui; Zhao, Mengzhen; Cai, Wenjia; Wang, Yong; Hu, Yixin; Tao, Shu; Guan, Dabo
  作者单位：Tsinghua University; Zhejiang University; University of California System; University of California Irvine; University of London; King's College London; University of Cambridge; Beijing Normal University; Tsinghua University; University of Southern California; University of Waterloo; Beijing Institute of Technology; Southeast University - China; Peking University; University of London; University College London
  摘要：Evidence shows a continuing increase in the frequency and severity of global heatwaves1,2, raising concerns about the future impacts of climate change and the associated socioeconomic costs3,4. Here we develop a disaster footprint analytical framework by integrating climate, epidemiological and hybrid input-output and computable general equilibrium global trade models to estimate the midcentury socioeconomic impacts of heat stress. We consider health costs related to heat exposure, the value o...
• Parental histone transfer caught at the replication fork AI翻译
  作者：Li, Ningning; Gao, Yuan; Zhang, Yujie; Yu, Daqi; Lin, Jianwei; Feng, Jianxun; Li, Jian; Xu, Zhichun; Zhang, Yingyi; Dang, Shangyu; Zhou, Keda; Liu, Yang; Li, Xiang David; Tye, Bik Kwoon; Li, Qing; Gao, Ning; Zhai, Yuanliang
  作者单位：Peking University; University of Hong Kong; Peking University; Peking University; Hong Kong University of Science & Technology; University of Hong Kong; Hong Kong University of Science & Technology; University of Hong Kong; Cornell University
  摘要：In eukaryotes, DNA compacts into chromatin through nucleosomes(1,2). Replication of the eukaryotic genome must be coupled to the transmission of the epigenome encoded in the chromatin(3,4). Here we report cryo-electron microscopy structures of yeast (Saccharomyces cerevisiae) replisomes associated with the FACT (facilitates chromatin transactions) complex (comprising Spt16 and Pob3) and an evicted histone hexamer. In these structures, FACT is positioned at the front end of the replisome by eng...
• The 'Mother Tree' idea is everywhere - but how much of it is real? AI翻译
  作者：Irwin, Aisling
  摘要：A popular theory about how trees cooperate has enchanted the public and raised the profile of forest conservation. But some ecologists think its scientific basis has been oversold.
• Disease-associated astrocyte epigenetic memory promotes CNS pathology AI翻译
  作者：Lee, Hong-Gyun; Rone, Joseph M.; Li, Zhaorong; Akl, Camilo Faust; Shin, Seung Won; Lee, Joon-Hyuk; Flausino, Lucas E.; Pernin, Florian; Chao, Chun-Cheih; Kleemann, Kilian L.; Srun, Lena; Illouz, Tomer; Giovannoni, Federico; Charabati, Marc; Sanmarco, Liliana M.; Kenison, Jessica E.; Piester, Gavin; Zandee, Stephanie E. J.; Antel, Jack P.; Rothhammer, Veit; Wheeler, Michael A.; Prat, Alexandre; Clark, Iain C.; Quintana, Francisco J.
  作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California Berkeley; McGill University; University of Portsmouth; University of Rochester; Universite de Montreal; University of Erlangen Nuremberg
  摘要：Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases, including multiple sclerosis and experimental autoimmune encephalomyelitis1-8 (EAE), an experimental model for multiple sclerosis. However, little is known about the stability of these astrocyte subsets and their ability to integrate past stimulation events. Here we report the identification of an epigenetically controlled memory astrocyte subset that exhibits exacerbated pro-inflammatory responses upon re...
• Communication barriers for a Deaf PhD student meant risking burnout AI翻译
  作者：Madhusoodanan, Jyoti
  摘要：Megan Majocha is gearing up to complete her PhD. But developing a sign-language lexicon to help her succeed took an immense toll during her scientific research.
• How a tree-hugging protest transformed Indian environmentalism AI翻译
  作者：Mundoli, Seema
  作者单位：Azim Premji Foundation; Azim Premji University Bengaluru
  摘要：Fifty years ago, a group of women from the villages of the Western Himalayas sparked Chipko, a green movement that remains relevant in the age of climate change.
• Superconductivity case shows the need for zero tolerance of toxic lab culture AI翻译
  作者：Werner, Juan Pablo Fuenzalida
  作者单位：Technical University of Munich
  摘要：Letter to the Editor
• The 'Anthropocene' is here to stay - and it's better not as a geological epoch AI翻译
  作者：Roland, Thomas P.; Swindles, Graeme T.; Ruffell, Alastair
  作者单位：University of Exeter; Queens University Belfast
  摘要：Letter to the Editor
• The surprising history of the Southern Ocean's super current AI翻译
  作者：Burls, Natalie J.
  作者单位：George Mason University
  摘要：Reconstructions of the strength of a powerful current that circles the South Pole reveal that it has undergone no long-term change in the past five million years, even though Earth cooled substantially over that time.