2024

最新文章

• In retrospect 50 years after a landmark paper on bird-flight origins AI翻译
  作者：Padian, Kevin
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley
• Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells (Feb, 10.1038/s41586-024-07121-9, 2024) AI翻译
  作者：Guan, Xiangnan; Hu, Ruozhen; Choi, Yoonha; Srivats, Shyam; Nabet, Barzin Y.; Silva, John; McGinnis, Lisa; Hendricks, Robert; Nutsch, Katherine; Banta, Karl L.; Duong, Ellen; Dunkle, Alexis; Chang, Patrick S.; Han, Chia-Jung; Mittman, Stephanie; Molden, Nandini; Daggumati, Pallavi; Connolly, Wendy; Johnson, Melissa; Abreu, Delvys Rodriguez; Cho, Byoung Chul; Italiano, Antoine; Gil-Bazo, Ignacio; Felip, Enriqueta; Mellman, Ira; Mariathasan, Sanjeev; Shames, David S.; Meng, Raymond; Chiang, Eugene Y.; Johnston, Robert J.; Patil, Namrata S.
• The structure and physical properties of a packaged bacteriophage particle AI翻译
  作者：Coshic, Kush; Maffeo, Christopher; Winogradoff, David; Aksimentiev, Aleksei
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：A string of nucleotides confined within a protein capsid contains all the instructions necessary to make a functional virus particle, a virion. Although the structure of the protein capsid is known for many virus species1,2, the three-dimensional organization of viral genomes has mostly eluded experimental probes3,4. Here we report all-atom structural models of an HK97 virion5, including its entire 39,732 base pair genome, obtained through multiresolution simulations. Mimicking the action of a...
• Don't underestimate the rising threat of groundwater to coastal cities AI翻译
  作者：Rozell, Daniel J.
  作者单位：State University of New York (SUNY) System; Stony Brook University
  摘要：Letter to the Editor
• Evolutionary trajectories of small cell lung cancer under therapy AI翻译
  作者：George, Julie; Maas, Lukas; Abedpour, Nima; Cartolano, Maria; Kaiser, Laura; Fischer, Rieke N.; Scheel, Andreas H.; Weber, Jan-Philipp; Hellmich, Martin; Bosco, Graziella; Volz, Caroline; Mueller, Christian; Dahmen, Ilona; John, Felix; Alves, Cleidson Padua; Werr, Lisa; Panse, Jens Peter; Kirschner, Martin; Engel-Riedel, Walburga; Juergens, Jessica; Stoelben, Erich; Brockmann, Michael; Grau, Stefan; Sebastian, Martin; Stratmann, Jan A.; Kern, Jens; Hummel, Horst-Dieter; Hegedues, Balazs; Schuler, Martin; Ploenes, Till; Aigner, Clemens; Elter, Thomas; Toepelt, Karin; Ko, Yon-Dschun; Kurz, Sylke; Grohe, Christian; Serke, Monika; Hoepker, Katja; Hagmeyer, Lars; Doerr, Fabian; Hekmath, Khosro; Strapatsas, Judith; Kambartel, Karl-Otto; Chakupurakal, Geothy; Busch, Annette; Bauernfeind, Franz-Georg; Griesinger, Frank; Luers, Anne; Dirks, Wiebke; Wiewrodt, Rainer; Luecke, Andrea; Rodermann, Ernst; Diel, Andreas; Hagen, Volker; Severin, Kai; Ullrich, Roland T.; Reinhardt, Hans Christian; Quaas, Alexander; Bogus, Magdalena; Courts, Cornelius; Nuernberg, Peter; Becker, Kerstin; Achter, Viktor; Buettner, Reinhard; Wolf, Juergen; Peifer, Martin; Thomas, Roman K.
  作者单位：University of Cologne; University of Cologne; University of Cologne; University of Cologne; University of Cologne; University of Cologne; University of Cologne; University of Cologne; RWTH Aachen University; RWTH Aachen University Hospital; University of Cologne; University of Cologne; Goethe University Frankfurt; Goethe University Frankfurt Hospital; Goethe University Frankfurt; Helmholtz Association; German Cancer Research Center (DKFZ); University of Wurzburg; University of Duisburg Essen; University of Duisburg Essen; Technische Universitat Dresden; Carl Gustav Carus University Hospital; Medical University of Vienna; University of Cologne; University of Cologne; University of Bonn; Pius-Hospital Oldenburg; University of Munster; St. Johannes Hospital; University of Duisburg Essen; University of Duisburg Essen; University of Cologne; University of Cologne; University of Cologne
  摘要：The evolutionary processes that underlie the marked sensitivity of small cell lung cancer (SCLC) to chemotherapy and rapid relapse are unknown1-3. Here we determined tumour phylogenies at diagnosis and throughout chemotherapy and immunotherapy by multiregion sequencing of 160 tumours from 65 patients. Treatment-naive SCLC exhibited clonal homogeneity at distinct tumour sites, whereas first-line platinum-based chemotherapy led to a burst in genomic intratumour heterogeneity and spatial clonal d...
• AI image generators often give racist and sexist results: can they be fixed? AI翻译
  作者：Ananya
  摘要：Researchers are tracing sources of racial and gender bias in images generated by artificial intelligence, and making efforts to fix them.
• What's the sign for 'centrifuge'? How we added scientific terms to Indian Sign Langua AI翻译
  作者：Padmanaban, Deepa
  摘要：Molecular biologist Alka Rao brought together her research group and sign-language specialists to broaden access to science for deaf students in India.
• Well-matched vibrations cool electronic hot spots AI翻译
  作者：Sang, Liwen
  作者单位：National Institute for Materials Science
  摘要：Diamond layers can help to dissipate the heat generated by high-power semiconductor devices. This effect has now been enhanced by adding layers of materials and engineering their crystal-lattice vibrations to be compatible at the interfaces.
• Cuts to postgraduate funding threaten Brazilian science - again AI翻译
  作者：Oliveira, Marcus F.; Todeschini, Adriane R.
  作者单位：Universidade Federal do Rio de Janeiro
  摘要：Letter to the Editor
• Resilient anatomy and local plasticity of naive and stress haematopoiesis AI翻译
  作者：Wu, Qingqing; Zhang, Jizhou; Kumar, Sumit; Shen, Siyu; Kincaid, Morgan; Johnson, Courtney B.; Zhang, Yanan Sophia; Turcotte, Raphael; Alt, Clemens; Ito, Kyoko; Homan, Shelli; Sherman, Bryan E.; Shao, Tzu-Yu; Slaughter, Anastasiya; Weinhaus, Benjamin; Song, Baobao; Filippi, Marie Dominique; Grimes, H. Leighton; Lin, Charles P.; Ito, Keisuke; Way, Sing Sing; Kofron, J. Matthew; Lucas, Daniel
  作者单位：Cincinnati Children's Hospital Medical Center; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Harvard University; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University; Cincinnati Children's Hospital Medical Center; Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：The bone marrow adjusts blood cell production to meet physiological demands in response to insults. The spatial organization of normal and stress responses are unknown owing to the lack of methods to visualize most steps of blood production. Here we develop strategies to image multipotent haematopoiesis, erythropoiesis and lymphopoiesis in mice. We combine these with imaging of myelopoiesis(1) to define the anatomy of normal and stress haematopoiesis. In the steady state, across the skeleton, ...