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作者：Long, Alice; Oswood, Christian J.; Kelly, Christopher B.; Bryan, Marian C.; MacMillan, David W. C.
作者单位：Princeton University; Johnson & Johnson; Johnson & Johnson USA; Janssen Biotech Inc; Johnson & Johnson; Johnson & Johnson USA; Janssen Biotech Inc
摘要：Heteroarenes are ubiquitous motifs in bioactive molecules, conferring favourable physical properties when compared to their arene counterparts(1-3). In particular, semisaturated heteroarenes possess attractive solubility properties and a higher fraction of sp(3) carbons, which can improve binding affinity and specificity. However, these desirable structures remain rare owing to limitations in current synthetic methods(4-6). Indeed, semisaturated heterocycles are laboriously prepared by means o...
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作者：Jamali, Kiarash; Kaell, Lukas; Zhang, Rui; Brown, Alan; Kimanius, Dari; Scheres, Sjors H. W.
作者单位：MRC Laboratory Molecular Biology; Royal Institute of Technology; Washington University (WUSTL); Harvard University; Harvard Medical School
摘要：Interpreting electron cryo-microscopy (cryo-EM) maps with atomic models requires high levels of expertise and labour-intensive manual intervention in three-dimensional computer graphics programs1,2. Here we present ModelAngelo, a machine-learning approach for automated atomic model building in cryo-EM maps. By combining information from the cryo-EM map with information from protein sequence and structure in a single graph neural network, ModelAngelo builds atomic models for proteins that are o...
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作者：Culagovski, Rodrigo
作者单位：Universidad Catolica del Norte; Pontificia Universidad Catolica de Chile
摘要：Life at the cutting edge.
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作者：Sanderson, Katharine
摘要：Editorial rebellions seem to be on the rise, as researchers seek more control over scholarly communication.
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作者：Ding, Bin; Ding, Yong; Peng, Jun; Romano-deGea, Jan; Frederiksen, Lindsey E. K.; Kanda, Hiroyuki; Syzgantseva, Olga A.; Syzgantseva, Maria A.; Audinot, Jean-Nicolas; Bour, Jerome; Zhang, Song; Wirtz, Tom; Fei, Zhaofu; Doerflinger, Patrick; Shibayama, Naoyuki; Niu, Yunjuan; Hu, Sixia; Zhang, Shunlin; Tirani, Farzaneh Fadaei; Liu, Yan; Yang, Guan-Jun; Brooks, Keith; Hu, Linhua; Kinge, Sachin; Dyakonov, Vladimir; Zhang, Xiaohong; Dai, Songyuan; Dyson, Paul J.; Nazeeruddin, Mohammad Khaja
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; North China Electric Power University; Soochow University - China; Lomonosov Moscow State University; Luxembourg Institute of Science & Technology; Chinese Academy of Sciences; Innovation Academy for Precision Measurement Science & Technology, CAS; University of Wurzburg; Toin University of Yokohama; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS; Southern University of Science & Technology; Xi'an Jiaotong University; Toyota Motor Corporation
摘要：Perovskite solar cells (PSCs) are among the most promising photovoltaic technologies owing to their exceptional optoelectronic properties 1,2 . However, the lower efficiency, poor stability and reproducibility issues of large-area PSCs compared with laboratory-scale PSCs are notable drawbacks that hinder their commercialization 3 . Here we report a synergistic dopant-additive combination strategy using methylammonium chloride (MACl) as the dopant and a Lewis-basic ionic-liquid additive, 1,3-bi...
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作者：[Anonymous]
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作者：Gibney, Elizabeth
摘要：The effect of melting polar ice could delay the need for a 'leap second' by three years.
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作者：Kappelman, John; Todd, Lawrence C.; Davis, Christopher A.; Cerling, Thure E.; Feseha, Mulugeta; Getahun, Abebe; Johnsen, Racheal; Kay, Marvin; Kocurek, Gary A.; Nachman, Brett A.; Negash, Agazi; Negash, Tewabe; O'Brien, Kaedan; Pante, Michael; Ren, Minghua; Smith, Eugene I.; Tabor, Neil J.; Tewabe, Dereje; Wang, Hong; Yang, Deming; Yirga, Solomon; Crowell, Jordan W.; Fanuka, Matthew F.; Habtie, Teshager; Hirniak, Jayde N.; Klehm, Carla; Loewen, Natalia D.; Melaku, Sahleselasie; Melton, Sierra M.; Myers, Timothy S.; Millonig, Sarah; Plummer, Megan C.; Riordan, Keenan J.; Rosenau, Nicholas A.; Skinner, Anne; Thompson, Abraham K.; Trombetta, Lindsey M.; Witzel, Adrienne; Assefa, Ephrem; Bodansky, Maria; Desta, Ayenachew A.; Campisano, Christopher J.; Dalmas, Daniel; Elliott, Connor; Endalamaw, Metasebia; Ford, Nicholas J.; Foster, Frederick; Getachew, Tomas; Haney, Yibai Li; Ingram, Brittney H.; Jackson, Jonayah; Marean, Curtis W.; Mattox, Sissi; de la Cruz Medina, Karla; Mulubrhan, Gebretsadkan; Porter, Keri; Roberts, Alexis; Santillan, Perla; Sollenberger, Alaric; Sponholtz, Julia; Valdes, Jessica; Wyman, Lani; Yadeta, Meklit; Yanny, Sierra
作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; Utah System of Higher Education; University of Utah; Addis Ababa University; Addis Ababa University; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; University of Arkansas System; University of Arkansas Fayetteville; Colorado State University System; Colorado State University Fort Collins; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Southern Methodist University; Beijing Normal University; University of Gondar; Arizona State University; Arizona State University-Tempe; Williams College; Bahir Dar University; Iowa State University; Rutgers University System; Rutgers University New Brunswick; Universite de Poitiers; Nelson Mandela University
摘要：Although modern humans left Africa multiple times over 100,000 years ago, those broadly ancestral to non-Africans dispersed less than 100,000 years ago(1). Most models hold that these events occurred through green corridors created during humid periods because arid intervals constrained population movements(2). Here we report an archaeological site-Shinfa-Metema 1, in the lowlands of northwest Ethiopia, with Youngest Toba Tuff cryptotephra dated to around 74,000 years ago-that provides early a...
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作者：Lenharo, Mariana
摘要：An Alabama court ruling that human embryos outside the uterus should be regarded as children has raised concerns among doctors and scientists.
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作者：Testard, Camille; Tremblay, Sebastien; Parodi, Felipe; DiTullio, Ron W.; Acevedo-Ithier, Arianna; Gardiner, Kristin L.; Kording, Konrad; Platt, Michael L.
作者单位：University of Pennsylvania; Harvard University; Laval University; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：Our understanding of the neurobiology of primate behaviour largely derives from artificial tasks in highly controlled laboratory settings, overlooking most natural behaviours that primate brains evolved to produce1-3. How primates navigate the multidimensional social relationships that structure daily life4 and shape survival and reproductive success5 remains largely unclear at the single-neuron level. Here we combine ethological analysis, computer vision and wireless recording technologies to...
