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作者：Camellato, Brendan R.; Brosh, Ran; Ashe, Hannah J.; Maurano, Matthew T.; Boeke, Jef D.
作者单位：NYU Langone Medical Center; NYU Langone Medical Center; NYU Langone Medical Center; New York University; New York University Tandon School of Engineering
摘要：Pervasive transcriptional activity is observed across diverse species. The genomes of extant organisms have undergone billions of years of evolution, making it unclear whether these genomic activities represent effects of selection or 'noise'1-4. Characterizing default genome states could help understand whether pervasive transcriptional activity has biological meaning. Here we addressed this question by introducing a synthetic 101-kb locus into the genomes of Saccharomyces cerevisiae and Mus ...
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作者：Campante, Tiago
作者单位：Universidade do Porto
摘要：An unusual technique picks up the slow vibration of a faint star.
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作者：Pearson, Helen
摘要：Researchers want to unpick how climate change affects mental health around the world - from lives that are disrupted by catastrophic weather to people who are anxious about the future.
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作者：Sears, Cynthia L.; Queen, Jessica
作者单位：Johns Hopkins University
摘要：Understanding the factors that drive formation of particular types of cancer can aid efforts to develop better diagnostics or treatments. The identification of a bacterial subspecies with a connection to colon cancer has clinical relevance.
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作者：Kulkarni, Sumeet
摘要：Scientists compiling a review scan more than 1,000 papers and find troubling images in some 10%.
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作者：Nierengarten, Iwona
作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS)
摘要：Nanoscale systems that release small molecules have potential therapeutic and industrial uses, but can result in low numbers of molecules reaching their target. A release system triggered by mechanical force offers a fresh approach.
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作者：Park, See-On; Hong, Seokman; Sung, Su-Jin; Kim, Dawon; Seo, Seokho; Jeong, Hakcheon; Park, Taehoon; Cho, Won Joon; Kim, Jeehwan; Choi, Shinhyun
作者单位：Korea Advanced Institute of Science & Technology (KAIST); Samsung Electronics; Samsung; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：Phase-change memory (PCM) has been considered a promising candidate for solving von Neumann bottlenecks owing to its low latency, non-volatile memory property and high integration density1,2. However, PCMs usually require a large current for the reset process by melting the phase-change material into an amorphous phase, which deteriorates the energy efficiency2-5. Various studies have been conducted to reduce the operation current by minimizing the device dimensions, but this increases the fab...
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作者：Turon, Gemma; Njoroge, Mathew; Mulubwa, Mwila; Duran-Frigola, Miquel; Chibale, Kelly
作者单位：University of Cape Town; University of Cape Town
摘要：Computational models that require very little data could transform biomedical and drug development research in Africa, as long as infrastructure, trained staff and secure databases are available.
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作者：Tufan, Turan; Comertpay, Gamze; Villani, Ambra; Nelson, Geoffrey M.; Terekhova, Marina; Kelley, Shannon; Zakharov, Pavel; Ellison, Rochelle M.; Shpynov, Oleg; Raymond, Michael; Sun, Jerry; Chen, Yitan; Bockelmann, Enno; Stremska, Marta; Peterson, Lance W.; Boeckaerts, Laura; Goldman, Seth R.; Etchegaray, J. Iker; Artyomov, Maxim N.; Peri, Francesca; Ravichandran, Kodi S.
作者单位：Washington University (WUSTL); University of Zurich; Harvard University; Harvard Medical School; University of Virginia; University of Virginia; Washington University (WUSTL); Flanders Institute for Biotechnology (VIB); Ghent University; Ghent University
摘要：During development, inflammation or tissue injury, macrophages may successively engulf and process multiple apoptotic corpses via efferocytosis to achieve tissue homeostasis1. How macrophages may rapidly adapt their transcription to achieve continuous corpse uptake is incompletely understood. Transcriptional pause/release is an evolutionarily conserved mechanism, in which RNA polymerase (Pol) II initiates transcription for 20-60 nucleotides, is paused for minutes to hours and is then released ...
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作者：Chowdhury, Rumman
