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作者：Quintans-Junior, Lucindo J.
作者单位：Universidade Federal de Sergipe
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作者：Wozniak, Michal; Ksieniewicz, Pawel
作者单位：Wroclaw University of Science & Technology
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作者：Glazebrook, Karl; Nanayakkara, Themiya; Schreiber, Corentin; Lagos, Claudia; Kawinwanichakij, Lalitwadee; Jacobs, Colin; Chittenden, Harry; Brammer, Gabriel; Kacprzak, Glenn G.; Labbe, Ivo; Marchesini, Danilo; Marsan, Z. Cemile; Oesch, Pascal A.; Papovich, Casey; Remus, Rhea-Silvia; Tran, Kim-Vy H.; Esdaile, James; Chandro-Gomez, Angel
作者单位：Swinburne University of Technology; University of Copenhagen; Niels Bohr Institute; University of Western Australia; Tufts University; York University - Canada; University of Geneva; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; University of Munich; University of New South Wales Sydney; Smithsonian Institution
摘要：The formation of galaxies by gradual hierarchical co-assembly of baryons and cold dark matter halos is a fundamental paradigm underpinning modern astrophysics(1,2) and predicts a strong decline in the number of massive galaxies at early cosmic times(3,4,5). Extremely massive quiescent galaxies (stellar masses of more than 10(11) M-circle dot) have now been observed as early as 1-2 billion years after the Big Bang(6,7,8,9,10,11,12,13). These galaxies are extremely constraining on theoretical mo...
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作者：Sandrini, Dario; Crow, James Mitchell
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作者：[Anonymous]
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作者：Nichakawade, Tushar D.; Ge, Jiaxin; Mog, Brian J.; Lee, Bum Seok; Pearlman, Alexander H.; Hwang, Michael S.; Dinapoli, Sarah R.; Wyhs, Nicolas; Marcou, Nikita; Glavaris, Stephanie; Konig, Maximilian F.; Gabelli, Sandra B.; Watson, Evangeline; Sterling, Cole; Wagner-Johnston, Nina; Rozati, Sima; Swinnen, Lode; Fuchs, Ephraim; Pardoll, Drew M.; Gabrielson, Kathy; Papadopoulos, Nickolas; Bettegowda, Chetan; Kinzler, Kenneth W.; Zhou, Shibin; Sur, Surojit; Vogelstein, Bert; Paul, Suman
作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Howard Hughes Medical Institute; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Roche Holding; Roche Holding USA; Genentech; Merck & Company; Merck & Company USA
摘要：Antibody and chimeric antigen receptor (CAR) T cell-mediated targeted therapies have improved survival in patients with solid and haematologic malignancies1-9. Adults with T cell leukaemias and lymphomas, collectively called T cell cancers, have short survival10,11 and lack such targeted therapies. Thus, T cell cancers particularly warrant the development of CAR T cells and antibodies to improve patient outcomes. Preclinical studies showed that targeting T cell receptor beta-chain constant reg...
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作者：Fang, Yuan; Bansal, Kushagra; Mostafavi, Sara; Benoist, Christophe; Mathis, Diane
作者单位：Harvard University; Harvard Medical School; Harvard University; Department of Science & Technology (India); Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR); University of Washington; University of Washington Seattle; Canadian Institute for Advanced Research (CIFAR)
摘要：AIRE is an unconventional transcription factor that enhances the expression of thousands of genes in medullary thymic epithelial cells and promotes clonal deletion or phenotypic diversion of self-reactive T cells1-4. The biological logic of AIRE's target specificity remains largely unclear as, in contrast to many transcription factors, it does not bind to a particular DNA sequence motif. Here we implemented two orthogonal approaches to investigate AIRE's cis-regulatory mechanisms: construction...
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作者：Wells, Sarah
摘要：As educators debate whether it's even possible to use AI safely in research and education, students are taking a role in shaping its responsible use.
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作者：Tsui, Yen-Chen; He, Minhao; Hu, Yuwen; Lake, Ethan; Wang, Taige; Watanabe, Kenji; Taniguchi, Takashi; Zaletel, Michael P.; Yazdani, Ali
作者单位：Princeton University; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; National Institute for Materials Science; National Institute for Materials Science
摘要：Wigner predicted that when the Coulomb interactions between electrons become much stronger than their kinetic energy, electrons crystallize into a closely packed lattice1. A variety of two-dimensional systems have shown evidence for Wigner crystals2-11 (WCs). However, a spontaneously formed classical or quantum WC has never been directly visualized. Neither the identification of the WC symmetry nor direct investigation of its melting has been accomplished. Here we use high-resolution scanning ...
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作者：Zepeda-Rivera, Martha; Minot, Samuel S.; Bouzek, Heather; Wu, Hanrui; Blanco-Miguez, Aitor; Manghi, Paolo; Jones, Dakota S.; LaCourse, Kaitlyn D.; Wu, Ying; McMahon, Elsa F.; Park, Soon-Nang; Lim, Yun K.; Kempchinsky, Andrew G.; Willis, Amy D.; Cotton, Sean L.; Yost, Susan C.; Sicinska, Ewa; Kook, Joong-Ki; Dewhirst, Floyd E.; Segata, Nicola; Bullman, Susan; Johnston, Christopher D.
作者单位：Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; University of Trento; Chosun University; Chosun University; University of Washington; University of Washington Seattle; Harvard University; Harvard University Medical Affiliates; Forsyth Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard School of Dental Medicine
摘要：Fusobacterium nucleatum (Fn), a bacterium present in the human oral cavity and rarely found in the lower gastrointestinal tract of healthy individuals(1), is enriched in human colorectal cancer (CRC) tumours(2-5). High intratumoural Fn loads are associated with recurrence, metastases and poorer patient prognosis(5-8). Here, to delineate Fn genetic factors facilitating tumour colonization, we generated closed genomes for 135 Fn strains; 80 oral strains from individuals without cancer and 55 uni...
