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作者：Smith, Linda B.
作者单位：Indiana University System; Indiana University Bloomington
摘要：Words and images experienced by an infant wearing sensors during their daily life have led to efficient machine learning, pointing to the power of multimodal training signals and to the potentially exploitable statistics of real-life experience.
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作者：Cobey, Kelly
作者单位：University of Ottawa; University of Ottawa Heart Institute; University of Ottawa
摘要：A move away from narrow assessment metrics such as high-impact publications is welcome, but a lack of planning and consultation mean the replacements are often no better.
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作者：Castelvecchi, Davide
摘要：The aspiring astronaut turned theoretical physicist talks travelling, the accelerating expansion of the Universe, thinking beyond three dimensions and detecting gravitational waves.
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作者：[Anonymous]
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作者：Haney, Michael S.; Palovics, Robert; Munson, Christy Nicole; Long, Chris; Johansson, Patrik K.; Yip, Oscar; Dong, Wentao; Rawat, Eshaan; West, Elizabeth; Schlachetzki, Johannes C. M.; Tsai, Andy; Guldner, Ian Hunter; Lamichhane, Bhawika S.; Smith, Amanda; Schaum, Nicholas; Calcuttawala, Kruti; Shin, Andrew; Wang, Yung-Hua; Wang, Chengzhong; Koutsodendris, Nicole; Serrano, Geidy E.; Beach, Thomas G.; Reiman, Eric M.; Glass, Christopher K.; Abu-Remaileh, Monther; Enejder, Annika; Huang, Yadong; Wyss-Coray, Tony
作者单位：Stanford University; Stanford University; Stanford University; University of California System; University of California San Francisco; The J David Gladstone Institutes; Stanford University; University of California System; University of California San Diego; University of California System; University of California San Francisco; Banner Research; Banner Health; Banner Sun Health Research Institute; Banner Research; Banner Health; Banner Alzheimer's Institute; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Stanford University
摘要：Several genetic risk factors for Alzheimer's disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells1. However, the relationship between lipid metabolism in glia and Alzheimer's disease pathology remains poorly understood. Through single-nucleus RNA sequencing of brain tissue in Alzheimer's disease, we have identified a microglial state defined by the expression of the lipid droplet-associated enzyme ACSL1 with ACSL1-positive micro...
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作者：[Anonymous]
摘要：Horses buried near the royal complex of Westminster in the fifteenth and sixteenth centuries had been imported from as far away as Scandinavia.
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作者：Karjalainen, Minna K.; Karthikeyan, Savita; Oliver-Williams, Clare; Sliz, Eeva; Allara, Elias; Fung, Wing Tung; Surendran, Praveen; Zhang, Weihua; Jousilahti, Pekka; Kristiansson, Kati; Salomaa, Veikko; Goodwin, Matt; Hughes, David A.; Boehnke, Michael; Silva, Lilian Fernandes; Yin, Xianyong; Mahajan, Anubha; Neville, Matt J.; van Zuydam, Natalie R.; de Mutsert, Renee; Li-Gao, Ruifang; Mook-Kanamori, Dennis O.; Demirkan, Ayse; Liu, Jun; Noordam, Raymond; Trompet, Stella; Chen, Zhengming; Kartsonaki, Christiana; Li, Liming; Lin, Kuang; Hagenbeek, Fiona A.; Hottenga, Jouke Jan; Pool, Rene; Ikram, M. Arfan; van Meurs, Joyce; Haller, Toomas; Milaneschi, Yuri; Kahonen, Mika; Mishra, Pashupati P.; Joshi, Peter K.; Macdonald-Dunlop, Erin; Mangino, Massimo; Zierer, Jonas; Acar, Ilhan E.; Hoyng, Carel B.; Lechanteur, Yara T. E.; Franke, Lude; Kurilshikov, Alexander; Zhernakova, Alexandra; Beekman, Marian; van den Akker, Erik B.; Kolcic, Ivana; Polasek, Ozren; Rudan, Igor; Gieger, Christian; Waldenberger, Melanie; Asselbergs, Folkert W.; Hayward, Caroline; Fu, Jingyuan; den Hollander, Anneke I.; Menni, Cristina; Spector, Tim D.; Wilson, James F.; Lehtimaki, Terho; Raitakari, Olli T.; Penninx, Brenda W. J. H.; Esko, Tonu; Walters, Robin G.; Jukema, J. Wouter; Sattar, Naveed; Ghanbari, Mohsen; van Dijk, Ko Willems; Karpe, Fredrik; McCarthy, Mark I.; Laakso, Markku; Jarvelin, Marjo-Riitta; Timpson, Nicholas J.; Perola, Markus; Kooner, Jaspal S.; Chambers, John C.; van Duijn, Cornelia; Slagboom, P. Eline; Boomsma, Dorret I.; Danesh, John; Ala-Korpela, Mika; Butterworth, Adam S.; Kettunen, Johannes
作者单位：University of Oulu; University of Oulu; University of Oulu; University of Oulu; University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; Imperial College London; University of Bristol; University of Bristol; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Eastern Finland; Nanjing Medical University; University of Oxford; Wellcome Centre for Human Genetics; University of Oxford; University of Oxford; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; University of Surrey; University of Surrey; University of Oxford; Erasmus University Rotterdam; Erasmus MC; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); University of Oxford; Peking University; Peking University; Peking University; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; University of Helsinki; Erasmus University Rotterdam; Erasmus MC; University of Tartu; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; University of Amsterdam; Tampere University; Tampere University; Tampere University Hospital; Tampere University; University of Edinburgh; University of London; King's College London; Guy's & St Thomas' NHS Foundation Trust; Swiss Federal Institutes of Technology Domain; ETH Zurich; Radboud University Nijmegen; University of Groningen; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Delft University of Technology; University of Split; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Munich Heart Alliance; German Centre for Cardiovascular Research; University of Amsterdam; University of London; University College London; University of London; University College London; University of Edinburgh; University of Groningen; AbbVie; University of Turku; University of Turku; University of Turku; University of Turku; University of Turku; University of Glasgow; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; University of Eastern Finland; University of Eastern Finland Hospital; Kuopio University Hospital; Brunel University; University of Oulu; University of Helsinki; University of Tartu; Imperial College London; Imperial College London; Imperial College London; Nanyang Technological University; Wellcome Trust Sanger Institute; University of Eastern Finland; Roche Holding; Roche Holding USA; Genentech
摘要：Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1-7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8-11. Here we present a genome-wide association study for 233 circulating metabolic traits quantified by nuclear magnetic resonance spectroscopy in up to 136,016 participan...
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作者：[Anonymous]
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作者：Radko-Juettner, Sandi; Yue, Hong; Myers, Jacquelyn A.; Carter, Raymond D.; Robertson, Alexis N.; Mittal, Priya; Zhu, Zhexin; Hansen, Baranda S.; Donovan, Katherine A.; Hunkeler, Moritz; Rosikiewicz, Wojciech; Wu, Zhiping; Mcreynolds, Meghan G.; Roy Burman, Shourya S.; Schmoker, Anna M.; Mageed, Nada; Brown, Scott A.; Mobley, Robert J.; Partridge, Janet F.; Stewart, Elizabeth A.; Pruett-Miller, Shondra M.; Nabet, Behnam; Peng, Junmin; Gray, Nathanael S.; Fischer, Eric S.; Roberts, Charles W. M.
作者单位：St Jude Children's Research Hospital; St Jude Children's Research Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; Fred Hutchinson Cancer Center; Stanford Cancer Institute
摘要：Whereas oncogenes can potentially be inhibited with small molecules, the loss of tumour suppressors is more common and is problematic because the tumour-suppressor proteins are no longer present to be targeted. Notable examples include SMARCB1-mutant cancers, which are highly lethal malignancies driven by the inactivation of a subunit of SWI/SNF (also known as BAF) chromatin-remodelling complexes. Here, to generate mechanistic insights into the consequences of SMARCB1 mutation and to identify ...
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作者：Nogales, Eva; Mahamid, Julia
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Howard Hughes Medical Institute; European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL)
摘要：Most life scientists would agree that understanding how cellular processes work requires structural knowledge about the macromolecules involved. For example, deciphering the double-helical nature of DNA revealed essential aspects of how genetic information is stored, copied and repaired. Yet, being reductionist in nature, structural biology requires the purification of large amounts of macromolecules, often trimmed off larger functional units. The advent of cryogenic electron microscopy (cryo-...
