作者：Doan, Alexander; Mueller, Katherine; Chen, Andy; Rouin, Geoffrey; Chen, Yingshi; Daniel, Bence; Lattin, John; Markovska, Martina; Mozarsky, Brett; Arias-Umana, Jose; Hapke, Robert; Jung, In-Young; Wang, Alice; Xu, Peng; Klysz, Dorota; Zuern, Gabrielle; Bashti, Malek; Quinn, Patrick; Miao, Zhuang; Sandor, Katalin; Zhang, Wenxi; Chen, Gregory; Ryu, Faith; Logun, Meghan; Hall, Junior; Tan, Kai; Grupp, Stephan; Mcclory, Susan; Lareau, Caleb; Fraietta, Joseph; Sotillo, Elena; Satpathy, Ansuman; Mackall, Crystal; Weber, Evan
作者单位：Stanford University; Stanford Cancer Institute; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Stanford University; Stanford University; Stanford University; Stanford University; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Stanford University; Stanford University; Roche Holding; Genentech; Roche Holding USA
摘要：A major limitation of chimeric antigen receptor (CAR) T cell therapies is the poor persistence of these cells in vivo 1 . The expression of memory-associated genes in CAR T cells is linked to their long-term persistence in patients and clinical efficacy 2-6 , suggesting that memory programs may underpin durable CAR T cell function. Here we show that the transcription factor FOXO1 is responsible for promoting memory and restraining exhaustion in human CAR T cells. Pharmacological inhibition or ...
作者：Li, Fei; Xing, Xudong; Jin, Qiqi; Wang, Xiang-Ming; Dai, Pengfei; Han, Ming; Shi, Huili; Zhang, Ze; Shao, Xianlong; Peng, Yunyi; Zhu, Yiqin; Xu, Jiayi; Li, Dan; Chen, Yu; Wu, Wei; Wang, Qiao; Yu, Chen; Chen, Luonan; Bai, Fan; Gao, Dong
作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; Peking University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; ShanghaiTech University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Normal University; Memorial Sloan Kettering Cancer Center; Fudan University; Shenzhen Bay Laboratory
摘要：Sex differences in mammalian complex traits are prevalent and are intimately associated with androgens1-7. However, a molecular and cellular profile of sex differences and their modulation by androgens is still lacking. Here we constructed a high-dimensional single-cell transcriptomic atlas comprising over 2.3 million cells from 17 tissues in Mus musculus and explored the effects of sex and androgens on the molecular programs and cellular populations. In particular, we found that sex-biased im...
作者：Cahill, Michelle K.; Collard, Max; Tse, Vincent; Reitman, Michael E.; Etchenique, Roberto; Kirst, Christoph; Poskanzer, Kira E.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos Aires; University of California System; University of California San Francisco; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：Astrocytes, the most abundant non-neuronal cell type in the mammalian brain, are crucial circuit components that respond to and modulate neuronal activity through calcium (Ca2+) signalling 1-7 . Astrocyte Ca2+ activity is highly heterogeneous and occurs across multiple spatiotemporal scales-from fast, subcellular activity 3,4 to slow, synchronized activity across connected astrocyte networks 8-10 -to influence many processes 5,7,11 . However, the inputs that drive astrocyte network dynamics re...
作者：Amar, David; Gay, Nicole R.; Jean-Beltran, Pierre M.; Bae, Dam; Dasari, Surendra; Dennis, Courtney; Evans, Charles R.; Gaul, David A.; Ilkayeva, Olga; Ivanova, Anna A.; Kachman, Maureen T.; Keshishian, Hasmik; Lanza, Ian R.; Lira, Ana C.; Muehlbauer, Michael J.; Nair, Venugopalan D.; Piehowski, Paul D.; Rooney, Jessica L.; Smith, Kevin S.; Stowe, Cynthia L.; Zhao, Bingqing; Clark, Natalie M.; Jimenez-Morales, David; Lindholm, Malene E.; Many, Gina M.; Sanford, James A.; Smith, Gregory R.; Vetr, Nikolai G.; Zhang, Tiantian; Armenteros, Jose J. Almagro; Avila-Pacheco, Julian; Bararpou, Nasim; Ge, Yongchao; Hou, Zhenxin; Marwaha, Shruti; Presby, David M.; Raja, Archana Natarajan; Savage, Evan M.; Steep, Alec; Sun, Yifei; Wu, Si; Zhen, Jimmy; Bodine, Sue C.; Esser, Karyn A.; Goodyear, Laurie J.; Schenk, Simon; Montgomery, Stephen B.; Fernandez, Facundo M.; Sealfon, Stuart C.; Snyder, Michael P.; Adkins, Joshua N.; Ashley, Euan; Burant, Charles F.; Carr, Steven A.; Clish, Clary B.; Cutter, Gary; Gerszten, Robert E.; Kraus, William E.; Li, Jun Z.; Miller, Michael E.; Nair, K. Sreekumaran; Newgard, Christopher; Ortlund, Eric A.; Qian, Wei-Jun; Tracy, Russell; Wheeler, Matthew T.; Dalton, Karen P.; Hastie, Trevor; Hershman, Steven G.; Samdarshi, Mihir; Teng, Christopher; Tibshirani, Rob; Cornell, Elaine; Gagne, Nicole; May, Sandy; Bouverat, Brian; Leeuwenburgh, Christiaan; Lu, Ching-ju; Pahor, Marco; Hsu, Fang-Chi; Rushing, Scott; Walkup, Michael P.; Nicklas, Barbara; Rejesk, W. Jack; Williams, John P.; Xia, Ashley; Albertson, Brent G.; Barton, Elisabeth R.; Booth, Frank W.; Caputo, Tiziana; Cicha, Michael; De Sousa, Luis Gustavo Oliveira; Farrar, Roger; Hevener, Andrea L.; Hirshman, Michael F.; Jackson, Bailey E.; Ke, Benjamin G.; Kramer, Kyle S.; Lessard, Sarah J.; Makarewicz, Nathan S.; Marshall, Andrea G.; Nigro, Pasquale; Powers, Scott; Ramachandran, Krithika; Recto, R. Scott; Richards, Collyn Z-T.; Thyfault, John; Yan, Zhen; Zang, Chongzhi; Amper, Mary Anne S.; Balci, Ali Tugrul; Chavez, Clarisa; Chikina, Maria; Chiu, Roxanne; Gritsenko, Marina A.; Guevara, Kristy; Hansen, Joshua R.; Hennig, Krista M.; Hung, Chia-Jui; Hutchinson-Bunch, Chelsea; Jin, Christopher A.; Liu, Xueyun; Maner-Smith, Kristal M.; Mani, D. R.; Marjanovic, Nada; Monroe, Matthew E.; Moore, Ronald J.; Moore, Samuel G.; Mundorff, Charles C.; Nachun, Daniel; Nestor, Michael D.; Nudelman, German; Pearce, Cadence; Petyuk, Vladislav A.; Pincas, Hanna; Ramos, Irene; Raskind, Alexander Sasha; Rirak, Stas; Robbins, Jeremy M.; Rubenstein, Aliza B.; Ruf-Zamojski, Frederique; Sagendorf, Tyler J.; Seenarine, Nitish; Soni, Tanu; Uppal, Karan; Vangeti, Sindhu; Vasoya, Mital; Vornholt, Alexandria; Walsh, Martin J.; Yu, Xuechen; Zaslavsky, Elena; Zebarjadi, Navid; Bamman, Marcas; Bergman, Bryan C.; Bessesen, Daniel H.; Buford, Thomas W.; Chambers, Toby L.; Coen, Paul M.; Cooper, Dan; Haddad, Fadia; Gadde, Kishore; Goodpaste, Bret H.; Harris, Melissa; Huffman, Kim M.; Jankowsk, Catherine M.; Johannsen, Neil M.; Kohr, Wendy M.; Kraus, William E.; Lester, Bridget; Melanson, Edward L.; Moreau, Kerrie L.; Musi, Nicolas; Newton, Robert L., Jr.; Radom-Aizik, Shlomit; Ramaker, Megan E.; Rankinen, Tuomo; Rasmussen, Blake B.; Ravussin, Eric; Schauer, Irene E.; Schwartz, Robert S.; Sparks, Lauren M.; Thalacker-Mercer, Anna; Trappe, Scott; Trappe, Todd A.; Volpi, Elena
作者单位：Stanford University; Stanford University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Iowa; Mayo Clinic; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Michigan System; University of Michigan; University System of Georgia; Georgia Institute of Technology; Duke University; Duke University; Emory University; University of Michigan System; University of Michigan; Mayo Clinic; Icahn School of Medicine at Mount Sinai; United States Department of Energy (DOE); Pacific Northwest National Laboratory; University of Vermont; Stanford University; Wake Forest University; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Emory University; Harvard University; Harvard University Medical Affiliates; Joslin Diabetes Center, Inc.; University of Michigan System; University of Michigan; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Oklahoma Medical Research Foundation; State University System of Florida; University of Florida; University of California System; University of California San Diego; Stanford University; University of Alabama System; University of Alabama Birmingham; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Wake Forest University; Mayo Clinic; Stanford University; Stanford University; State University System of Florida; University of Florida; Wake Forest University; Wake Forest University; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); State University System of Florida; University of Florida; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Texas System; University of Texas Austin; University of California System; University of California Los Angeles; University of Virginia; Harvard University; Harvard University Medical Affiliates; Joslin Diabetes Center, Inc.; Vanderbilt University; Stetson University; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Kansas; University of Kansas Medical Center; University of Virginia; University of Virginia; University of Virginia; University of Virginia; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University System of Georgia; Georgia Institute of Technology; Emory University; University of Alabama System; University of Alabama Birmingham; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Alabama System; University of Alabama Birmingham; Ball State University; Adventist Health Services; AdventHealth; University of California System; University of California Irvine; Louisiana State University System; Louisiana State University; Pennington Biomedical Research Center; University of Colorado System; University of Colorado Anschutz Medical Campus; Cedars Sinai Medical Center; Louisiana State University System; Louisiana State University; Pennington Biomedical Research Center; University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas at San Antonio
摘要：Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood 1-3 . Here, the Molecular Transducers of Physical Activity Consortium 4 profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and female Rattus norvegicus over eight weeks of endurance exercise training. The resulting data...
