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作者:Fedorenko, Evelina; Piantadosi, Steven T.; Gibson, Edward A. F.
作者单位:Massachusetts Institute of Technology (MIT); Harvard University; University of California System; University of California Berkeley
摘要:Language is a defining characteristic of our species, but the function, or functions, that it serves has been debated for centuries. Here we bring recent evidence from neuroscience and allied disciplines to argue that in modern humans, language is a tool for communication, contrary to a prominent view that we use language for thinking. We begin by introducing the brain network that supports linguistic ability in humans. We then review evidence for a double dissociation between language and tho...
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作者:Kozlov, Max
摘要:Study in rats shows that a key brain signal linked to memory formation deteriorates after broken sleep.
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作者:Kulkarni, Sumeet
摘要:Sports physicist Eric Goff explains how updates to the technology can help referees to make the toughest calls.
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作者:Li, Kai; Chatterjee, Avradip; Qian, Chen; Lagree, Katherine; Wang, Yang; Becker, Courtney A.; Freeman, Michael R.; Murali, Ramachandran; Yang, Wei; Underhill, David M.
作者单位:Cedars Sinai Medical Center; Cedars Sinai Medical Center; Cedars Sinai Medical Center; Cedars Sinai Medical Center; Cedars Sinai Medical Center; Cedars Sinai Medical Center; Cedars Sinai Medical Center
摘要:Phagocytosis is the process by which myeloid phagocytes bind to and internalize potentially dangerous microorganisms(1). During phagocytosis, innate immune receptors and associated signalling proteins are localized to the maturing phagosome compartment, forming an immune information processing hub brimming with microorganism-sensing features(2-8). Here we developed proximity labelling of phagosomal contents (PhagoPL) to identify proteins localizing to phagosomes containing model yeast and bact...
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作者:Lindhout, Feline W.; Krienen, Fenna M.; Pollard, Katherine S.; Lancaster, Madeline A.
作者单位:MRC Laboratory Molecular Biology; Princeton University; University of California System; University of California San Francisco; The J David Gladstone Institutes; Chan Zuckerberg Initiative (CZI); University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要:The evolution of the modern human brain was accompanied by distinct molecular and cellular specializations, which underpin our diverse cognitive abilities but also increase our susceptibility to neurological diseases. These features, some specific to humans and others shared with related species, manifest during different stages of brain development. In this multi-stage process, neural stem cells proliferate to produce a large and diverse progenitor pool, giving rise to excitatory or inhibitor...
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作者:Ivanov, Pavel
作者单位:Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School
摘要:The enzyme angiogenin functions in stress responses and aids the formation of blood vessels. It emerges that the ribosome takes a break from its usual role of making proteins to activate angiogenin and position it to cleave transfer RNA.
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作者:Lee, Anthony T.; Chang, Edward F.; Paredes, Mercedes F.; Nowakowski, Tomasz J.
作者单位:University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要:Advances in large-scale single-unit human neurophysiology, single-cell RNA sequencing, spatial transcriptomics and long-term ex vivo tissue culture of surgically resected human brain tissue have provided an unprecedented opportunity to study human neuroscience. In this Perspective, we describe the development of these paradigms, including Neuropixels and recent brain-cell atlas efforts, and discuss how their convergence will further investigations into the cellular underpinnings of network-lev...
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作者:Nogrady, Bianca
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作者:Pearson, Helen
摘要:Synthesizing research on which policies are most effective is a key priority in climate science, advocates say.
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作者:Shamay-Tsoory, Simone; Maroun, Mouna; Abu-Akel, Ahmad; Avraham, Roi; Atzil, Shir
作者单位:University of Haifa; Weizmann Institute of Science; Hebrew University of Jerusalem