2024

最新文章

• Titanium:sapphire-on-insulator integrated lasers and amplifiers AI翻译
  作者：Yang, Joshua; Van Gasse, Kasper; Lukin, Daniil M.; Guidry, Melissa A.; Ahn, Geun Ho; White, Alexander D.; Vuckovic, Jelena
  作者单位：Stanford University; Interuniversity Microelectronics Centre; Ghent University
  摘要：Titanium:sapphire (Ti:sapphire) lasers have been essential for advancing fundamental research and technological applications, including the development of the optical frequency comb1, two-photon microscopy2 and experimental quantum optics3,4. Ti:sapphire lasers are unmatched in bandwidth and tuning range, yet their use is restricted because of their large size, cost and need for high optical pump powers5. Here we demonstrate a monocrystalline titanium:sapphire-on-insulator (Ti:SaOI) photonics ...
• Bridge RNAs direct programmable recombination of target and donor DNA AI翻译
  作者：Durrant, Matthew G.; Perry, Nicholas T.; Pai, James J.; Jangid, Aditya R.; Athukoralage, Januka S.; Hiraizumi, Masahiro; McSpedon, John P.; Pawluk, April; Nishimasu, Hiroshi; Konermann, Silvana; Hsu, Patrick D.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California San Francisco; University of Tokyo; University of Tokyo; University of Tokyo; Japan Science & Technology Agency (JST); Stanford University; University of California System; University of California Berkeley
  摘要：Genomic rearrangements, encompassing mutational changes in the genome such as insertions, deletions or inversions, are essential for genetic diversity. These rearrangements are typically orchestrated by enzymes that are involved in fundamental DNA repair processes, such as homologous recombination, or in the transposition of foreign genetic material by viruses and mobile genetic elements1,2. Here we report that IS110 insertion sequences, a family of minimal and autonomous mobile genetic elemen...
• Acceleration of radiative recombination for efficient perovskite LEDs (vol 630, pg 631, 2024) AI翻译
  作者：Li, Mengmeng; Yang, Yingguo; Kuang, Zhiyuan; Hao, Chenjie; Wang, Saixue; Lu, Feiyue; Liu, Zhongran; Liu, Jinglong; Zeng, Lingjiao; Cai, Yuxiao; Mao, Yulin; Guo, Jingshu; Tian, He; Xing, Guichuan; Cao, Yu; Ma, Chao; Wang, Nana; Peng, Qiming; Zhu, Lin; Huang, Wei; Wang, Jianpu
• Structural insights into the cross-exon to cross-intron spliceosome switch AI翻译
  作者：Zhang, Zhenwei; Kumar, Vinay; Dybkov, Olexandr; Will, Cindy L.; Zhong, Jiayun; Ludwig, Sebastian E. J.; Urlaub, Henning; Kastner, Berthold; Stark, Holger; Luehrmann, Reinhard
  作者单位：Sichuan University; Sichuan University; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL
  摘要：Early spliceosome assembly can occur through an intron-defined pathway, whereby U1 and U2 small nuclear ribonucleoprotein particles (snRNPs) assemble across the intron(1). Alternatively, it can occur through an exon-defined pathway(2-5), whereby U2 binds the branch site located upstream of the defined exon and U1 snRNP interacts with the 5 ' splice site located directly downstream of it. The U4/U6.U5 tri-snRNP subsequently binds to produce a cross-intron (CI) or cross-exon (CE) pre-B complex, ...
• Translation tool embraces overlooked languages AI翻译
  作者：Adelani, David I.
  作者单位：University of London; University College London; McGill University; Mila Quebec Artificial Intelligence Institute
• How climate change is harming health in Europe AI翻译
  作者：Wong, Carissa
• Sleep loss diminishes hippocampal reactivation and replay AI翻译
  作者：Giri, Bapun; Kinsky, Nathaniel; Kaya, Utku; Maboudi, Kourosh; Abel, Ted; Diba, Kamran
  作者单位：University of Michigan System; University of Michigan; University of Wisconsin System; University of Wisconsin Milwaukee; University of Iowa; University of Michigan System; University of Michigan
  摘要：Memories benefit from sleep(1), and the reactivation and replay of waking experiences during hippocampal sharp-wave ripples (SWRs) are considered to be crucial for this process(2). However, little is known about how these patterns are impacted by sleep loss. Here we recorded CA1 neuronal activity over 12 h in rats across maze exploration, sleep and sleep deprivation, followed by recovery sleep. We found that SWRs showed sustained or higher rates during sleep deprivation but with lower power an...
• AI translators need cultural competence AI翻译
  作者：Tenzer, Helene; Feuerriegel, Stefan; Piekkari, Rebecca
  作者单位：University of Munich; Aalto University
• Two decades of deep ice cores from Antarctica AI翻译
  作者：Kawamura, Kenji; Oyabu, Ikumi
  作者单位：Research Organization of Information & Systems (ROIS); National Institute of Polar Research (NIPR) - Japan
  摘要：In June 2004, the results of an ambitious Antarctic ice-drilling project brought insight into hundreds of thousands of years of climatic changes. The extraordinary sample still has much to offer climate research - even as its successor is being drilled.
• Plasmid targeting and destruction by the DdmDE bacterial defence system AI翻译
  作者：Bravo, Jack P. K.; Ramos, Delisa A.; Fregoso Ocampo, Rodrigo; Ingram, Caiden; Taylor, David W.
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; Institute of Science & Technology - Austria
  摘要：Although eukaryotic Argonautes have a pivotal role in post-transcriptional gene regulation through nucleic acid cleavage, some short prokaryotic Argonaute variants (pAgos) rely on auxiliary nuclease factors for efficient foreign DNA degradation1. Here we reveal the activation pathway of the DNA defence module DdmDE system, which rapidly eliminates small, multicopy plasmids from the Vibrio cholerae seventh pandemic strain (7PET)2. Through a combination of cryo-electron microscopy, biochemistry ...