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作者：Jiang, Yuehua; Jahagirdar, Balkrishna N.; Reinhardt, R. Lee; Schwartz, Robert E.; Keene, C. Dirk; Ortiz-Gonzalez, Xilma R.; Reyes, Morayma; Lenvik, Todd; Lund, Troy; Blackstad, Mark; Du, Jingbo; Aldrich, Sara; Lisberg, Aaron; Low, Walter C.; Largaespada, David A.; Verfaillie, Catherine M.
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
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作者：Wynne-Cattanach, Bethan L.; Couto, Nicole; Drake, Henri F.; Ferrari, Raffaele; Le Boyer, Arnaud; Mercier, Herle; Messias, Marie-Jose; Ruan, Xiaozhou; Spingys, Carl P.; van Haren, Hans; Voet, Gunnar; Polzin, Kurt; Garabato, Alberto C. Naveira; Alford, Matthew H.
作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography; University of California System; University of California Irvine; Massachusetts Institute of Technology (MIT); Institut de Recherche pour le Developpement (IRD); Ifremer; Universite de Bretagne Occidentale; Centre National de la Recherche Scientifique (CNRS); University of Exeter; Boston University; NERC National Oceanography Centre; Utrecht University; Royal Netherlands Institute for Sea Research (NIOZ); Woods Hole Oceanographic Institution; University of Southampton
摘要：Small-scale turbulent mixing drives the upwelling of deep water masses in the abyssal ocean as part of the global overturning circulation1. However, the processes leading to mixing and the pathways through which this upwelling occurs remain insufficiently understood. Recent observational and theoretical work2-5 has suggested that deep-water upwelling may occur along the ocean's sloping seafloor; however, evidence has, so far, been indirect. Here we show vigorous near-bottom upwelling across is...
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作者：[Anonymous]
摘要：Should one principal investigator have the power to determine postdocs' careers? Share your thoughts on academia's dominant funding model in our survey and reader poll.
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作者：Ahmed, Anees; Joseph, Ann M.; Zhou, Jordan; Horn, Veronika; Uddin, Jazib; Lyu, Mengze; Goc, Jeremy; Sockolow, Robbyn E.; Wing, James B.; Vivier, Eric; Sakaguchi, Shimon; Sonnenberg, Gregory F.
作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; University of Osaka; University of Osaka; University of Osaka; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille; Kyoto University
摘要：Interleukin (IL-)23 is a major mediator and therapeutic target in chronic inflammatory diseases that also elicits tissue protection in the intestine at homeostasis or following acute infection(1-4). However, the mechanisms that shape these beneficial versus pathological outcomes remain poorly understood. To address this gap in knowledge, we performed single-cell RNA sequencing on all IL-23 receptor-expressing cells in the intestine and their acute response to IL-23, revealing a dominance of T ...
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作者：Bader, Jackie E.; Wolf, Melissa M.; Lupica-Tondo, Gian Luca; Madden, Matthew Z.; Reinfeld, Bradley I.; Arner, Emily N.; Hathaway, Emma S.; Steiner, KayLee K.; Needle, Gabriel A.; Hatem, Zaid; Landis, Madelyn D.; Faneuff, Eden E.; Blackman, Amondrea; Wolf, Elysa M.; Cottam, Matthew A.; Ye, Xiang; Bates, Madison E.; Smart, Kyra; Wang, Wenjun; Pinheiro, Laura V.; Christofides, Anthos; Smith, DuPreez; Boussiotis, Vassiliki A.; Haake, Scott M.; Beckermann, Kathryn E.; Wellen, Kathryn E.; Reinhart-King, Cynthia A.; Serezani, C. Henrique; Lee, Cheng-Han; Aubrey, Christa; Chen, Heidi; Rathmell, W. Kimryn; Hasty, Alyssa H.; Rathmell, Jeffrey C.
作者单位：Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; University of Pennsylvania; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; University of Alberta; Vanderbilt University; University of Pennsylvania; University of Alberta; Vanderbilt University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Tennessee Valley Healthcare System
摘要：Obesity is a leading risk factor for progression and metastasis of many cancers(1,2), yet can in some cases enhance survival(3-5) and responses to immune checkpoint blockade therapies, including anti-PD-1, which targets PD-1 (encoded by PDCD1), an inhibitory receptor expressed on immune cells6-8. Although obesity promotes chronic inflammation, the role of the immune system in the obesity-cancer connection and immunotherapy remains unclear. It has been shown that in addition to T cells, macroph...
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作者：[Anonymous]
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作者：Zavitsanou, Anastasia-Maria; Abdus-Saboor, Ishmail
作者单位：Columbia University; Columbia University; Howard Hughes Medical Institute
摘要：A little-studied sensory structure called the Krause corpuscle is responsible for detecting light touch and is essential for normal sexual behaviour in mice. The findings have interesting implications for human sexual intimacy.
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作者：Lu, Jun; Wu, Wenbing; Colombari, Felippe Mariano; Jawaid, Ali; Seymour, Bryan; Whisnant, Kody; Zhong, Xiaoyang; Choi, Wonjin; Chalmpes, Nikolaos; Lahann, Joerg; Vaia, Richard A.; de Moura, Andre Farias; Nepal, Dhriti; Kotov, Nicholas A.
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; United States Department of Defense; United States Air Force; US Air Force Research Laboratory; UES, Inc.; ARCTOS; Cornell University; Universidade Federal de Sao Carlos; University of Michigan System; University of Michigan
摘要：Composites from 2D nanomaterials show uniquely high electrical, thermal and mechanical properties1,2. Pairing their robustness with polarization rotation is needed for hyperspectral optics in extreme conditions3,4. However, the rigid nanoplatelets have randomized achiral shapes, which scramble the circular polarization of photons with comparable wavelengths. Here we show that multilayer nanocomposites from 2D nanomaterials with complex textured surfaces strongly and controllably rotate light p...
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作者：[Anonymous]
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作者：Benjamin, Katherine; Bhandari, Aneesha; Kepple, Jessica D.; Qi, Rui; Shang, Zhouchun; Xing, Yanan; An, Yanru; Zhang, Nannan; Hou, Yong; Crockford, Tanya L.; McCallion, Oliver; Issa, Fadi; Hester, Joanna; Tillmann, Ulrike; Harrington, Heather A.; Bull, Katherine R.
作者单位：University of Oxford; University of Oxford; Wellcome Centre for Human Genetics; University of Oxford; University of Oxford; Chinese Academy of Medical Sciences - Peking Union Medical College; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Oxford; University of Cambridge; Max Planck Society; Technische Universitat Dresden
摘要：Spatial transcriptomics measures in situ gene expression at millions of locations within a tissue(1), hitherto with some trade-off between transcriptome depth, spatial resolution and sample size(2). Although integration of image-based segmentation has enabled impactful work in this context, it is limited by imaging quality and tissue heterogeneity. By contrast, recent array-based technologies offer the ability to measure the entire transcriptome at subcellular resolution across large samples(3...
