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作者：Mallapaty, Smriti
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作者：Plackett, Benjamin
摘要：Shobhana Narasimhan, chair of the Indian Academy of Science's initiative on women in science, says attitudes in the field must change more quickly.
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作者：Breen, Gerome
作者单位：University of London; King's College London
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作者：Hu, Maowei; Yang, Lei; Twarog, Nathaniel; Ochoada, Jason; Li, Yong; Vrettos, Eirinaios I.; Torres-Hernandez, Arnaldo X.; Martinez, James B.; Bhatia, Jiya; Young, Brandon M.; Price, Jeanine; McGowan, Kevin; Nguyen, Theresa H.; Shi, Zhe; Anyanwu, Matthew; Rimmer, Mary Ashley; Mercer, Shea; Rankovic, Zoran; Shelat, Anang A.; Blair, Daniel J.
作者单位：St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital
摘要：The automated synthesis of small organic molecules from modular building blocks has the potential to transform our capacity to create medicines and materials(1-3). Disruptive acceleration of this molecule-building strategy broadly unlocks its functional potential and requires the integration of many new assembly chemistries. Although recent advances in high-throughput chemistry(4-6) can speed up the development of appropriate synthetic methods, for example, in selecting appropriate chemical re...
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作者：Blattman, Sydney B.; Jiang, Wenyan; McGarrigle, E. Riley; Liu, Menghan; Oikonomou, Panos; Tavazoie, Saeed
作者单位：Columbia University; Columbia University; Columbia University; Icahn School of Medicine at Mount Sinai
摘要：Persister cells, rare phenotypic variants that survive normally lethal levels of antibiotics, present a major barrier to clearing bacterial infections(1). However, understanding the precise physiological state and genetic basis of persister formation has been a longstanding challenge. Here we generated a high-resolution single-cell(2) RNA atlas of Escherichia coli growth transitions, which revealed that persisters from diverse genetic and physiological models converge to transcriptional states...
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作者：Lenharo, Mariana
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作者：Savage, Neil
摘要：Researchers believe the next generation of wearable devices will transform diagnosis and treatment.
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作者：Soliman, Alix
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作者：Taucher, Jan; Bach, Lennart T.; Prowe, A. E. Friederike; Boxhammer, Tim; Kvale, Karin; Riebesell, Ulf
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作者：Huang, Qin Qin; Wigdor, Emilie M.; Malawsky, Daniel S.; Campbell, Patrick; Samocha, Kaitlin E.; Chundru, V. Kartik; Danecek, Petr; Lindsay, Sarah; Marchant, Thomas; Koko, Mahmoud; Amanat, Sana; Bonfanti, Davide; Sheridan, Eamonn; Radford, Elizabeth J.; Barrett, Jeffrey C.; Wright, Caroline F.; Firth, Helen V.; Warrier, Varun; Strudwick Young, Alexander; Hurles, Matthew E.; Martin, Hilary C.
作者单位：Wellcome Trust Sanger Institute; University of London; King's College London; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Exeter; University of Leeds; Saint James's University Hospital; Chapel Allerton Hospital; University of Cambridge; University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge; University of Cambridge; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：Although rare neurodevelopmental conditions have a large Mendelian component(1), common genetic variants also contribute to risk(2,3). However, little is known about how this polygenic risk is distributed among patients with these conditions and their parents nor its interplay with rare variants. It is also unclear whether polygenic background affects risk directly through alleles transmitted from parents to children, or whether indirect genetic effects mediated through the family environment(...
