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作者：Renz, Peter F.; Ghoshdastider, Umesh; Sain, Simona Baghai; Valdivia-Francia, Fabiola; Khandekar, Ameya; Ormiston, Mark; Bernasconi, Martino; Dure, Clara; Kretz, Jonas A.; Lee, Minkyoung; Hyams, Katie; Forny, Merima; Pohly, Marcel; Ficht, Xenia; Ellis, Stephanie J.; Moor, Andreas E.; Sendoel, Ataman
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Medical University of Vienna; University of Vienna; Vienna Biocenter (VBC); Max F. Perutz Laboratories (MFPL); University of Vienna
摘要：The tumour evolution model posits that malignant transformation is preceded by randomly distributed driver mutations in cancer genes, which cause clonal expansions in phenotypically normal tissues. Although clonal expansions can remodel entire tissues(1-3), the mechanisms that result in only a small number of clones transforming into malignant tumours remain unknown. Here we develop an in vivo single-cell CRISPR strategy to systematically investigate tissue-wide clonal dynamics of the 150 most...
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作者：Ferry, Georgina
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作者：Pan, Xu; Li, Xin; Dong, Liang; Liu, Teng; Zhang, Min; Zhang, Lining; Zhang, Xiyuan; Huang, Lingjuan; Shi, Wensheng; Sun, Hongyin; Fang, Zhaoyu; Sun, Jie; Huang, Yaoxuan; Shao, Hua; Wang, Yeqi; Yin, Mingzhu
作者单位：Chongqing University; Chongqing University; Tsinghua University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Peking Union Medical College Hospital; Chongqing University; Central South University; Central South University; Southern Medical University - China; Central South University; Chongqing University
摘要：Tumours can obtain nutrients and oxygen required to progress and metastasize through the blood supply(1). Inducing angiogenesis involves the sprouting of established vessel beds and their maturation into an organized network(2,3). Here we generate a comprehensive atlas of tumour vasculature at single-cell resolution, encompassing approximately 200,000 cells from 372 donors representing 31 cancer types. Trajectory inference suggested that tumour angiogenesis was initiated from venous endothelia...
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作者：Wang, Wei-Ting; Holzhey, Philippe; Zhou, Ning; Zhang, Qiang; Zhou, Suer; Duijnstee, Elisabeth A.; Rietwyk, Kevin J.; Lin, Jeng-Yu; Mu, Yijie; Zhang, Yanfeng; Bach, Udo; Wu, Chun-Guey; Yip, Hin-Lap; Snaith, Henry J.; Feng, Shien-Ping
作者单位：City University of Hong Kong; University of Oxford; Monash University; City University of Hong Kong; Xi'an Jiaotong University; Tunghai University; University of Hong Kong; National Central University; National Central University; City University of Hong Kong; City University of Hong Kong; City University of Hong Kong
摘要：Further improvements in perovskite solar cells require better control of ionic defects in the perovskite photoactive layer during the manufacturing stage and their usage(1-5). Here we report a living passivation strategy using a hindered urea/thiocarbamate bond(6-8) Lewis acid-base material (HUBLA), where dynamic covalent bonds with water and heat-activated characteristics can dynamically heal the perovskite to ensure device performance and stability. Upon exposure to moisture or heat, HUBLA g...
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作者：Gao, Frank Y.; Peng, Xinyue; Cheng, Xinle; Boestrom, Emil Vinas; Kim, Dong Seob; Jain, Ravish K.; Vishnu, Deepak; Raju, Kalaivanan; Sankar, Raman; Lee, Shang-Fan; Sentef, Michael A.; Kurumaji, Takashi; Li, Xiaoqin; Tang, Peizhe; Rubio, Angel; Baldini, Edoardo
作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; Max Planck Society; University of Basque Country; Academia Sinica - Taiwan; National Tsing Hua University; University of Bremen; University of Bremen; California Institute of Technology; Simons Foundation; Flatiron Institute
摘要：Helical spin structures are expressions of magnetically induced chirality, entangling the dipolar and magnetic orders in materials(1-4). The recent discovery of helical van der Waals multiferroics down to the ultrathin limit raises prospects of large chiral magnetoelectric correlations in two dimensions(5,6). However, the exact nature and magnitude of these couplings have remained unknown so far. Here we perform a precision measurement of the dynamical magnetoelectric coupling for an enantiopu...
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作者：Gernon, Thomas M.; Hincks, Thea K.; Brune, Sascha; Braun, Jean; Jones, Stephen M.; Keir, Derek; Cunningham, Alice; Glerum, Anne
作者单位：University of Southampton; NERC National Oceanography Centre; Helmholtz Association; Helmholtz-Center Potsdam GFZ German Research Center for Geosciences; University of Potsdam; University of Birmingham; University of Florence
摘要：Many cratonic continental fragments dispersed during the rifting and break-up of Gondwana are bound by steep topographic landforms known as 'great escarpments'1-4, which rim elevated plateaus in the craton interior5,6. In terms of formation, escarpments and plateaus are traditionally considered distinct owing to their spatial separation, occasionally spanning more than a thousand kilometres. Here we integrate geological observations, statistical analysis, geodynamic simulations and landscape-e...
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作者：[Anonymous]
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作者：Padma, T. V.
摘要：The government has focused on areas of national pride and applied science, as many researchers expected.
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作者：Simiyu, Donah
作者单位：Council for Scientific & Industrial Research (CSIR) - South Africa
摘要：The country can tackle its energy crisis by diversifying its energy sources, using storage systems and continually optimizing its grid.
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作者：Yang, Hong
作者单位：University of Reading
摘要：Letter to the Editor
