-
作者：[Anonymous]
-
作者：Liu, C. M.; Zhao, B. N.; Cao, J. B.; Pollock, C. J.; Russell, C. T.; Liu, Y. Y.; Xing, X. N.; Linqvist, P. A.; Burch, J. L.
作者单位：Beihang University; University of California System; University of California Los Angeles; Royal Institute of Technology; Southwest Research Institute
摘要：Chorus waves are some of the strongest electromagnetic emissions naturally occurring in space and can cause radiation that is hazardous to humans and satellites1, 2-3. Although chorus waves have attracted extreme interest and been intensively studied for decades4, 5, 6-7, their generation and evolution remain highly debated7. Here, in contrast to the conventional expectation that chorus waves are governed by planetary magnetic dipolar fields5,7, we report observations of repetitive, rising-ton...
-
作者：Xing, Huaipeng; Rosenkranz, Remus R. E.; Rodriguez-Aliaga, Piere; Lee, Ting-Ting; Majtner, Tomas; Boehm, Stefanie; Turonova, Beata; Frydman, Judith; Beck, Martin
作者单位：Max Planck Society; Goethe University Frankfurt; Stanford University; Goethe University Frankfurt
摘要：The ring-shaped chaperonin T-complex protein ring complex (TRiC; also known as chaperonin containing TCP-1, CCT) is an ATP-driven protein-folding machine that is essential for maintenance of cellular homeostasis1,2. Its dysfunction is related to cancer and neurodegenerative disease3,4. Despite its importance, how TRiC works in the cell remains unclear. Here we structurally analysed the architecture, conformational dynamics and spatial organization of the chaperonin TRiC in human cells using cr...
-
作者：Roure, Baptiste; Alonso, Maialen; Lonardi, Giovanni; Yildiz, Dilara Berna; Buettner, Cornelia S.; dos Santos, Thiago; Xu, Yan; Bossart, Martin; Derdau, Volker; Mendez, Maria; Llaveria, Josep; Ruffoni, Alessandro; Leonori, Daniele
作者单位：University of Manchester; RWTH Aachen University; Gazi University; Sanofi-Aventis; Sanofi Germany; Johnson & Johnson; Johnson & Johnson Spain
摘要：Thiazoles and isothiazoles are privileged motifs in drug and agrochemical discovery1,2. The synthesis of these derivatives is generally approached, designed and developed on a case-by-case basis. Sometimes, the lack of robust synthesis methods to a given target can pose considerable difficulties or even thwart the preparation of specific derivatives for further study3,4. Here we report a conceptually different approach in which photochemical irradiation can be used to alter the structure of th...
-
作者：Guglielmi, Giorgia
-
作者：Jones, Nicola
-
作者：Munoz, Jose M.; Bernacer, Javier; Noe, Alva; Thompson, Evan
作者单位：University of Navarra; University of California System; University of California Berkeley; University of British Columbia
-
作者：Liu, Lei; Huang, Yi; Gyakum, John R.
作者单位：McGill University
摘要：Clouds greatly influence the Earth's energy balance1,2. Observationally constraining cloud radiative feedback, a notably uncertain climate feedback mechanism3, 4-5, is crucial for improving predictions of climate change5, 6-7 but, so far, remains an elusive objective, and the feedback may be different over the ocean versus over land8, 9-10. Here we show a local negative surface longwave cloud feedback over land at the southern Great Plains site, constrained by direct long-term observation of s...
-
作者：Niyas, M. A.; Shoyama, Kazutaka; Gruene, Matthias; Wuerthner, Frank
作者单位：University of Wurzburg; University of Wurzburg
摘要：Graphene is a single-layered sp2-hybridized carbon allotrope, which is impermeable to all atomic entities other than hydrogen1,2. The introduction of defects allows selective gas permeation3, 4-5; efforts have been made to control the size of these defects for higher selectivity6, 7, 8-9. Permeation of entities other than gases, such as ions10,11, is of fundamental scientific interest because of its potential application in desalination, detection and purification12, 13, 14, 15-16. However, a ...
-
作者：Witze, Alexandra
