8047期

最新文章

• Oxidative cyclization reagents reveal tryptophan cation-π interactions (vol 627, pg 680, 2024) AI翻译
  作者：Xie, Xiao; Moon, Patrick J.; Crossley, Steven W. M.; Bischoff, Amanda J.; He, Dan; Li, Gen; Dao, Nam; Gonzalez-Valero, Angel; Reeves, Audrey G.; Mckenna, Jeffrey M.; Elledge, Susanna K.; Wells, James A.; Toste, F. Dean; Chang, Christopher J.
• Neuromorphic computing at scale AI翻译
  作者：Kudithipudi, Dhireesha; Schuman, Catherine; Vineyard, Craig M.; Pandit, Tej; Merkel, Cory; Kubendran, Rajkumar; Aimone, James B.; Orchard, Garrick; Mayr, Christian; Benosman, Ryad; Hays, Joe; Young, Cliff; Bartolozzi, Chiara; Majumdar, Amitava; Cardwell, Suma George; Payvand, Melika; Buckley, Sonia; Kulkarni, Shruti; Gonzalez, Hector A.; Cauwenberghs, Gert; Thakur, Chetan Singh; Subramoney, Anand; Furber, Steve
  作者单位：University of Texas System; University of Texas at San Antonio; University of Tennessee System; University of Tennessee Knoxville; United States Department of Energy (DOE); Sandia National Laboratories; Rochester Institute of Technology; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Intel Corporation; Intel USA; Technische Universitat Dresden; United States Department of Defense; United States Navy; United States Naval Research Laboratory; Alphabet Inc.; DeepMind; Istituto Italiano di Tecnologia - IIT; University of California System; University of California San Diego; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; National Institute of Standards & Technology (NIST) - USA; United States Department of Energy (DOE); Oak Ridge National Laboratory; Indian Institute of Science (IISC) - Bangalore; University of London; Royal Holloway University London; University of Manchester
  摘要：Neuromorphic computing is a brain-inspired approach to hardware and algorithm design that efficiently realizes artificial neural networks. Neuromorphic designers apply the principles of biointelligence discovered by neuroscientists to design efficient computational systems, often for applications with size, weight and power constraints. With this research field at a critical juncture, it is crucial to chart the course for the development of future large-scale neuromorphic systems. We describe ...
• A deep catalogue of protein-coding variation in 983,578 individuals (vol 631, pg 583, 2024) AI翻译
  作者：Sun, Kathie Y.; Bai, Xiaodong; Chen, Siying; Bao, Suying; Zhang, Chuanyi; Kapoor, Manav; Backman, Joshua; Joseph, Tyler; Maxwell, Evan; Mitra, George; Gorovits, Alexander; Mansfield, Adam; Boutkov, Boris; Gokhale, Sujit; Habegger, Lukas; Marcketta, Anthony; Locke, Adam E.; Ganel, Liron; Hawes, Alicia; Kessler, Michael D.; Sharma, Deepika; Staples, Jeffrey; Bovijn, Jonas; Gelfman, Sahar; Di Gioia, Alessandro; Rajagopal, Veera M.; Lopez, Alexander; Varela, Jennifer Rico; Alegre-Diaz, Jesus; Berumen, Jaime; Tapia-Conyer, Roberto; Kuri-Morales, Pablo; Torres, Jason; Emberson, Jonathan; Collins, Rory; Cantor, Michael; Thornton, Timothy; Kang, Hyun Min; Overton, John D.; Shuldiner, Alan R.; Cremona, M. Laura; Nafde, Mona; Baras, Aris; Abecasis, Gonccalo; Marchini, Jonathan; Reid, Jeffrey G.; Salerno, William; Balasubramanian, Suganthi
• Ab initio characterization of protein molecular dynamics with AI2BMD (vol 635, pg 1019, 2024) AI翻译
  作者：Wang, Tong; He, Xinheng; Li, Mingyu; Li, Yatao; Bi, Ran; Wang, Yusong; Cheng, Chaoran; Shen, Xiangzhen; Meng, Jiawei; Zhang, He; Liu, Haiguang; Wang, Zun; Li, Shaoning; Shao, Bin; Liu, Tie-Yan
  作者单位：Microsoft; Microsoft China
• Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers AI翻译
  作者：Steffin, David; Ghatwai, Nisha; Montalbano, Antonino; Rathi, Purva; Courtney, Amy N.; Arnett, Azlann B.; Fleurence, Julien; Sweidan, Ramy; Wang, Tao; Zhang, Huimin; Masand, Prakash; Maris, John M.; Martinez, Daniel; Pogoriler, Jennifer; Varadarajan, Navin; Thakkar, Sachin G.; Lyon, Deborah; Lapteva, Natalia; Zhuyong, Mei; Patel, Kalyani; Lopez-Terrada, Dolores; Ramos, Carlos A.; Lulla, Premal; Armaghany, Tannaz; Grilley, Bambi J.; Gottschalk, Stephen; Dotti, Gianpietro; Metelitsa, Leonid S.; Heslop, Helen E.; Brenner, Malcolm K.; Sumazin, Pavel; Heczey, Andras
  作者单位：Texas Children's Cancer Center; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Houston Methodist; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Baylor College of Medicine; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Houston System; University of Houston; Baylor College of Medicine; University of North Carolina; University of North Carolina Chapel Hill; Baylor College of Medicine; Baylor College Medical Hospital
  摘要：Interleukin-15 (IL-15) promotes the survival of T lymphocytes and enhances the antitumour properties of chimeric antigen receptor (CAR) T cells in preclinical models of solid neoplasms in which CAR T cells have limited efficacy1-4. Glypican-3 (GPC3) is expressed in a group of solid cancers5-10, and here we report the evaluation in humans of the effects of IL-15 co-expression on GPC3-expressing CAR T cells (hereafter GPC3 CAR T cells). Cohort 1 patients (NCT02905188 and NCT02932956) received GP...
• H5N1 clade 2.3.4.4b dynamics in experimentally infected calves and cows AI翻译
  作者：Halwe, Nico Joel; Cool, Konner; Breithaupt, Angele; Schoen, Jacob; Trujillo, Jessie D.; Nooruzzaman, Mohammed; Kwon, Taeyong; Ahrens, Ann Kathrin; Britzke, Tobias; Mcdowell, Chester D.; Piesche, Ronja; Singh, Gagandeep; dos Reis, Vinicius Pinho; Kafle, Sujan; Pohlmann, Anne; Gaudreault, Natasha N.; Corleis, Bjoern; Ferreyra, Franco Matias; Carossino, Mariano; Balasuriya, Udeni B. R.; Hensley, Lisa; Morozov, Igor; Covaleda, Lina M.; Diel, Diego G.; Ulrich, Lorenz; Hoffmann, Donata; Beer, Martin; Richt, Juergen A.
  作者单位：Friedrich Loeffler Institute; Kansas State University; Friedrich Loeffler Institute; Cornell University; Friedrich Loeffler Institute; Kansas State University; Louisiana State University System; Louisiana State University; Louisiana State University School of Veterinary Medicine; Louisiana State University School of Veterinary Medicine; Louisiana State University System; Louisiana State University; United States Department of Agriculture (USDA)
  摘要：In March 2024, highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b H5N1 infections were reported in dairy cows in Texas, USA1. Rapid dissemination to more than 380 farms in 14 states followed2. Here we provide results of two independent clade 2.3.4.4b experimental infection studies evaluating the oronasal susceptibility to and transmission of a US H5N1 bovine isolate, genotype B3.13 (H5N1 B3.13), in calves, and the susceptibility of lactating cows following direct mammary gland inoc...
• Conformational protection of molybdenum nitrogenase by Shethna protein II AI翻译
  作者：Franke, Philipp; Freiberger, Simon; Zhang, Lin; Einsle, Oliver
  作者单位：University of Freiburg
  摘要：The oxygen-sensitive molybdenum-dependent nitrogenase of Azotobacter vinelandii is protected from oxidative damage by a reversible 'switch-off' mechanism1. It forms a complex with a small ferredoxin, FeSII (ref. 2) or the 'Shethna protein II'3, which acts as an O2 sensor and associates with the two component proteins of nitrogenase when its [2Fe:2S] cluster becomes oxidized4,5. Here we report the three-dimensional structure of the protective ternary complex of the catalytic subunit of Mo-nitro...
• Brown dwarf in neighbouring solar system is actually a spinning duo AI翻译
  作者：Xuan, Jerry W.; Oppenheimer, Rebecca
  作者单位：California Institute of Technology; American Museum of Natural History (AMNH)
  摘要：The nearby star Gliese 229 harbours a 'brown dwarf' companion: an object less massive than a star but more massive than a planet. High-resolution observations reveal that it is two objects, each about 30 times the mass of Jupiter, that circle one another every 12 days as they orbit their sun every few hundred years.
• Obituary: Jimmy Carter (1924-2024) AI翻译
  作者：Jacobson, Julie
• Earth breaches 1.5 °C climate limit for the first time: what does it mean? AI翻译
  作者：Tollefson, Jeff