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作者：Song, Huimin; Muench, Konrad; Liu, Xu; Shen, Kaier; Zhang, Ruizhuo; Weintraut, Timo; Yusim, Yuriy; Jiang, Dequan; Hong, Xufeng; Meng, Jiashen; Liu, Yatao; He, Mengxue; Li, Yitao; Henkel, Philip; Brezesinski, Torsten; Janek, Juergen; Pang, Quanquan
作者单位：Peking University; Justus Liebig University Giessen; Justus Liebig University Giessen; Helmholtz Association; Karlsruhe Institute of Technology
摘要：With promises for high specific energy, high safety and low cost, the all-solid-state lithium-sulfur battery (ASSLSB) is ideal for next-generation energy storage1, 2, 3, 4-5. However, the poor rate performance and short cycle life caused by the sluggish solid-solid sulfur redox reaction (SSSRR) at the three-phase boundaries remain to be solved. Here we demonstrate a fast SSSRR enabled by lithium thioborophosphate iodide (LBPSI) glass-phase solid electrolytes (GSEs). On the basis of the reversi...
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作者：Narehood, Sarah M.; Cook, Brian D.; Srisantitham, Suppachai; Eng, Vanessa H.; Shiau, Angela A.; Mcguire, Kelly L.; Britt, R. David; Herzik Jr, Mark A.; Tezcan, F. Akif
作者单位：University of California System; University of California San Diego; University of California System; University of California Davis
摘要：The low reduction potentials required for the reduction of dinitrogen (N2) render metal-based nitrogen-fixation catalysts vulnerable to irreversible damage by dioxygen (O2)1, 2-3. Such O2 sensitivity represents a major conundrum for the enzyme nitrogenase, as a large fraction of nitrogen-fixing organisms are either obligate aerobes or closely associated with O2-respiring organisms to support the high energy demand of catalytic N2 reduction4. To counter O2 damage to nitrogenase, diazotrophs use...
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作者：Picard, Lewis R. B.; Park, Annie J.; Patenotte, Gabriel E.; Gebretsadkan, Samuel; Wellnitz, David; Rey, Ana Maria; Ni, Kang-Kuen
作者单位：Harvard University; Harvard University; Harvard University; National Institute of Standards & Technology (NIST) - USA; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
摘要：Quantum computation and simulation rely on long-lived qubits with controllable interactions. Trapped polar molecules have been proposed as a promising quantum computing platform, offering scalability and single-particle addressability while still leveraging inherent complexity and strong couplings of molecules1-5. Recent progress in the single quantum state preparation and coherence of the hyperfine-rotational states of individually trapped molecules allows them to serve as promising qubits6-1...
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作者：Castelvecchi, Davide
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作者：Huston, Sara
作者单位：Ann & Robert H. Lurie Children's Hospital of Chicago
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作者：Pradella, Davide; Zhang, Minsi; Gao, Rui; Yao, Melissa A.; Gluchowska, Katarzyna M.; Cendon-Florez, Ylenia; Mishra, Tanmay; La Rocca, Gaspare; Weigl, Moritz; Jiao, Ziqi; Nguyen, Hieu H. M.; Lisi, Marta; Ozimek, Mateusz M.; Mastroleo, Chiara; Chen, Kevin; Grimm, Felix; Luebeck, Jens; Zhang, Shu; Zolli, Andrea Alice; Sun, Eric G.; Dameracharla, Bhargavi; Zhao, Zhengqiao; Pritykin, Yuri; Sigel, Carlie; Chang, Howard Y.; Mischel, Paul S.; Bafna, Vineet; Antonescu, Cristina R.; Ventura, Andrea
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; University of California System; University of California San Diego; Stanford University; Stanford University; Stanford University; Stanford University; Memorial Sloan Kettering Cancer Center; Rockefeller University; Cornell University; Weill Cornell Medicine; Princeton University; Princeton University; Memorial Sloan Kettering Cancer Center; Howard Hughes Medical Institute; Stanford University; University of California System; University of California San Diego
摘要：Focal gene amplifications are among the most common cancer-associated mutations1 but have proven challenging to engineer in primary cells and model organisms. Here we describe a general strategy to engineer large (more than 1 Mbp) focal amplifications mediated by extrachromosomal DNAs (ecDNAs)2 in a spatiotemporally controlled manner in cells and in mice. By coupling ecDNA formation with expression of selectable markers, we track the dynamics of ecDNA-containing cells under physiological condi...
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作者：Docter-Loeb, Hannah
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作者：[Anonymous]
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作者：Beltran, Antoni; Jiang, Xiang'er; Shen, Yue; Lehner, Ben
作者单位：Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Beijing Genomics Institute (BGI); Beijing Genomics Institute (BGI); Pompeu Fabra University; ICREA; Wellcome Trust Sanger Institute
摘要：Missense variants that change the amino acid sequences of proteins cause one-third of human genetic diseases1. Tens of millions of missense variants exist in the current human population, and the vast majority of these have unknown functional consequences. Here we present a large-scale experimental analysis of human missense variants across many different proteins. Using DNA synthesis and cellular selection experiments we quantify the effect of more than 500,000 variants on the abundance of mo...
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作者：Bromley-Trujillo, Rebecca
作者单位：Christopher Newport University
