8047期

最新文章

• Got flu? Promising drug shortens symptoms AI翻译
  作者：[Anonymous]
• Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1 AI翻译
  作者：Jian, Fanchong; Wang, Jing; Yisimayi, Ayijiang; Song, Weiliang; Xu, Yanli; Chen, Xiaosu; Niu, Xiao; Yang, Sijie; Yu, Yuanling; Wang, Peng; Sun, Haiyan; Yu, Lingling; Wang, Jing; Wang, Yao; An, Ran; Wang, Wenjing; Ma, Miaomiao; Xiao, Tianhe; Gu, Qingqing; Shao, Fei; Wang, Youchun; Shen, Zhongyang; Jin, Ronghua; Cao, Yunlong
  作者单位：Peking University; Changping Laboratory; Peking University; Peking University; Capital Medical University; Nankai University; Tsinghua University; Peking University; National Institute of Biological Sciences, Beijing; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Institute of Medical Biology - CAMS; Nankai University
  摘要：The continuous evolution of SARS-CoV-2, particularly the emergence of the BA.2.86/JN.1 lineage replacing XBB, necessitates re-evaluation of vaccine compositions1, 2-3. Here, we provide a comprehensive analysis of the humoral immune response to XBB and JN.1 human exposure. We demonstrate the antigenic distinctiveness of XBB and JN.1 lineages in SARS-CoV-2-naive individuals and show that infection with JN.1 elicits superior plasma neutralization against its subvariants. We highlight the strong i...
• AI hallucinations can't be stopped - but these techniques can limit their damage AI翻译
  作者：Jones, Nicola
• I explore the impact of wildfires on Hawaii's coral reefs AI翻译
  作者：Nogrady, Bianca
• Bidirectional histone monoaminylation dynamics regulate neural rhythmicity AI翻译
  作者：Zheng, Qingfei; Weekley, Benjamin H.; Vinson, David A.; Zhao, Shuai; Bastle, Ryan M.; Thompson, Robert E.; Stransky, Stephanie; Ramakrishnan, Aarthi; Cunningham, Ashley M.; Dutta, Sohini; Chan, Jennifer C.; Di Salvo, Giuseppina; Chen, Min; Zhang, Nan; Wu, Jinghua; Fulton, Sasha L.; Kong, Lingchun; Wang, Haifeng; Zhang, Baichao; Vostal, Lauren; Upad, Akhil; Dierdorff, Lauren; Shen, Li; Molina, Henrik; Sidoli, Simone; Muir, Tom W.; Li, Haitao; David, Yael; Maze, Ian
  作者单位：James Cancer Hospital & Solove Research Institute; University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute; University System of Ohio; Ohio State University; Icahn School of Medicine at Mount Sinai; Tsinghua University; Princeton University; Yeshiva University; Maastricht University; Memorial Sloan Kettering Cancer Center; Rockefeller University; Shanxi Medical University; Tsinghua University; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Icahn School of Medicine at Mount Sinai; Howard Hughes Medical Institute; Icahn School of Medicine at Mount Sinai; Purdue University System; Purdue University
  摘要：Histone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression1, 2-3. We previously demonstrated that serotonylation4, 5, 6, 7, 8, 9-10 and dopaminylation9,11, 12-13 of Gln5 of histone H3 (H3Q5ser and H3Q5dop, respectively) are catalysed by transglutaminase 2 (TG2), and alter both local and global chromatin states. Here we found that TG2 additionally functions as an eraser and exchanger of H3 monoaminylation...
• Chirping chorus rings out from an unexpected part of outer space AI翻译
  作者：Horne, Richard B.
• Dairy cows inoculated with highly pathogenic avian influenza virus H5N1 AI翻译
  作者：Baker, Amy L.; Arruda, Bailey; Palmer, Mitchell V.; Boggiatto, Paola; Davila, Kaitlyn Sarlo; Buckley, Alexandra; Zanella, Giovana Ciacci; Snyder, Celeste A.; Anderson, Tavis K.; Hutter, Carl R.; Nguyen, Thao-Quyen; Markin, Alexey; Lantz, Kristina; Posey, Erin A.; Torchetti, Mia Kim; Robbe-Austerman, Suelee; Magstadt, Drew R.; Gorden, Patrick J.
  作者单位：United States Department of Agriculture (USDA); USDA Agricultural Research Service; United States Department of Agriculture (USDA); USDA Agricultural Research Service; Iowa State University
  摘要：Highly pathogenic avian influenza (HPAI) H5N1 haemagglutinin clade 2.3.4.4b was detected in the USA in 2021. These HPAI viruses caused mortality events in poultry, wild birds and wild mammals. On 25 March 2024, HPAI H5N1 clade 2.3.4.4b was confirmed in a dairy cow in Texas in response to a multistate investigation into milk production losses1. More than 200 positive herds were identified in 14 US states. The case description included reduced feed intake and rumen motility in lactating cows, de...
• AI-designed proteins tackle century-old problem - making snake antivenoms AI翻译
  作者：Callaway, Ewen
• Self-driving laboratories, advanced immunotherapies and five more technologies to watch in 2025 AI翻译
  作者：Eisenstein, Michael
• Voter turnout drives margins of victory ― if elections are fair AI翻译
  作者：[Anonymous]