8050期

最新文章

• Complex rearrangements fuel ER+ and HER2+ breast tumours AI翻译
  作者：Houlahan, Kathleen E.; Mangiante, Lise; Sotomayor-Vivas, Cristina; Adimoelja, Alvina; Park, Seongyeol; Khan, Aziz; Pribus, Sophia J.; Ma, Zhicheng; Caswell-Jin, Jennifer L.; Curtis, Christina
  作者单位：Stanford University; Stanford Cancer Institute; Stanford University; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
  摘要：Breast cancer is a highly heterogeneous disease whose prognosis and treatment as defined by the expression of three receptors-oestrogen receptor (ER), progesterone receptor and human epidermal growth factor receptor 2 (HER2; encoded by ERBB2)-is insufficient to capture the full spectrum of clinical outcomes and therapeutic vulnerabilities. Previously, we demonstrated that transcriptional and genomic profiles define eleven integrative subtypes with distinct clinical outcomes, including four ER+...
• Saturation genome editing-based clinical classification of BRCA2 variants AI翻译
  作者：Sahu, Sounak; Galloux, Melissa; Southon, Eileen; Caylor, Dylan; Sullivan, Teresa; Arnaudi, Matteo; Zanti, Maria; Geh, Josephine; Chari, Raj; Michailidou, Kyriaki; Papaleo, Elena; Sharan, Shyam K.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Technical University of Denmark; Cyprus Institute of Neurology & Genetics; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research
  摘要：Sequencing-based genetic tests have uncovered a vast array of BRCA2 sequence variants1. Owing to limited clinical, familial and epidemiological data, thousands of variants are considered to be variants of uncertain significance2, 3-4 (VUS). Here we have utilized CRISPR-Cas9-based saturation genome editing in a humanized mouse embryonic stem cell line to determine the functional effect of VUS. We have categorized nearly all possible single nucleotide variants (SNVs) in the region that encodes t...
• Distributed quantum computing across an optical network link AI翻译
  作者：Main, D.; Drmota, P.; Nadlinger, D. P.; Ainley, E. M.; Agrawal, A.; Nichol, B. C.; Srinivas, R.; Araneda, G.; Lucas, D. M.
  作者单位：University of Oxford
  摘要：Distributed quantum computing (DQC) combines the computing power of multiple networked quantum processing modules, ideally enabling the execution of large quantum circuits without compromising performance or qubit connectivity1,2. Photonic networks are well suited as a versatile and reconfigurable interconnect layer for DQC; remote entanglement shared between matter qubits across the network enables all-to-all logical connectivity through quantum gate teleportation (QGT)3,4. For a scalable DQC...
• Bat genomes illuminate adaptations to viral tolerance and disease resistance AI翻译
  作者：Morales, Ariadna E.; Dong, Yue; Brown, Thomas; Baid, Kaushal; Kontopoulos, Dimitrios-Georgios; Gonzalez, Victoria; Huang, Zixia; Ahmed, Alexis-Walid; Bhuinya, Arkadeb; Hilgers, Leon; Winkler, Sylke; Hughes, Graham; Li, Xiaomeng; Lu, Ping; Yang, Yixin; Kirilenko, Bogdan M.; Devanna, Paolo; Lama, Tanya M.; Nissan, Yomiran; Pippel, Martin; Davalos, Liliana M.; Vernes, Sonja C.; Puechmaille, Sebastien J.; Rossiter, Stephen J.; Yovel, Yossi; Prescott, Joseph B.; Kurth, Andreas; Ray, David A.; Lim, Burton K.; Myers, Eugene; Teeling, Emma C.; Banerjee, Arinjay; Irving, Aaron T.; Hiller, Michael
  作者单位：Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Goethe University Frankfurt; University of Edinburgh; Zhejiang University; Max Planck Society; Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR); University of Saskatchewan; University of Saskatchewan; University College Dublin; Max Planck Society; State University of New York (SUNY) System; Stony Brook University; Tel Aviv University; Tel Aviv University; State University of New York (SUNY) System; Stony Brook University; University of St Andrews; Institut Universitaire de France; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; University of London; Queen Mary University London; Robert Koch Institute; Texas Tech University System; Texas Tech University; Royal Ontario Museum; University of Waterloo; University of Toronto; University of British Columbia; Zhejiang University; Zhejiang University; University of Edinburgh; Smith College
  摘要：Zoonoses are infectious diseases transmitted from animals to humans. Bats have been suggested to harbour more zoonotic viruses than any other mammalian order1. Infections in bats are largely asymptomatic2,3, indicating limited tissue-damaging inflammation and immunopathology. To investigate the genomic basis of disease resistance, the Bat1K project generated reference-quality genomes of ten bat species, including potential viral reservoirs. Here we describe a systematic analysis covering 115 m...
• Specification of claustro-amygdalar and palaeocortical neurons and circuits AI翻译
  作者：Kaur, Navjot; Kovner, Rothem; Gulden, Forrest O.; Pletikos, Mihovil; Andrijevic, David; Zhu, Tianjia; Silbereis, John; Shibata, Mikihito; Shibata, Akemi; Liu, Yuting; Ma, Shaojie; Salla, Nikkita; de Martin, Xabier; Klaric, Thomas S.; Burke, Megan; Franjic, Daniel; Cho, Hyesun; Yuen, Matthew; Chatterjee, Ipsita; Soric, Paula; Esakkimuthu, Devippriya; Moser, Markus; Santpere, Gabriel; Mineur, Yann S.; Pattabiraman, Kartik; Picciotto, Marina R.; Huang, Hao; Sestan, Nenad
  作者单位：Yale University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Yale University; Hospital del Mar Research Institute; Hospital del Mar; Pompeu Fabra University; Barcelona Biomedical Research Park; Technical University of Munich; Yale University; Yale University; University of Pennsylvania; Yale University; Yale University; Yale University; Yale University
  摘要：The ventrolateral pallial (VLp) excitatory neurons in the claustro-amygdalar complex and piriform cortex (PIR; which forms part of the palaeocortex) form reciprocal connections with the prefrontal cortex (PFC), integrating cognitive and sensory information that results in adaptive behaviours1, 2, 3, 4-5. Early-life disruptions in these circuits are linked to neuropsychiatric disorders4, 5, 6, 7-8, highlighting the importance of understanding their development. Here we reveal that the transcrip...
• Bonobos know when you're in the know ― and when you're not AI翻译
  作者：[Anonymous]
• An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA ( vol 461 , pg 230 , 2009) AI翻译
  作者：Maida, Yoshiko; Yasukawa, Mami; Furuuchi, Miho; Lassmann, Timo; Possemato, Richard; Okamoto, Naoko; Kasim, Vivi; Hayashizaki, Yoshihide; Hahn, William C.; Masutomi, Kenkichi
  作者单位：National Cancer Center - Japan; RIKEN; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Japan Science & Technology Agency (JST)
• A way to disperse clusters of circulating tumour cells AI翻译
  作者：Smit, Daniel J.; Pantel, Klaus
  作者单位：University of Hamburg; University Medical Center Hamburg-Eppendorf
• Resolving native GABAA receptor structures from the human brain AI翻译
  作者：Zhou, Jia; Noviello, Colleen M.; Teng, Jinfeng; Moore, Haley; Lega, Bradley; Hibbs, Ryan E.
  作者单位：University of California System; University of California San Diego; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of California System; University of California San Diego
  摘要：Type A GABA (gamma-aminobutyric acid) receptors (GABAA receptors) mediate most fast inhibitory signalling in the brain and are targets for drugs that treat epilepsy, anxiety, depression and insomnia and for anaesthetics1,2. These receptors comprise a complex array of 19 related subunits, which form pentameric ligand-gated ion channels. The composition and structure of native GABAA receptors in the human brain have been inferred from subunit localization in tissue1,3, functional measurements an...
• Polytype switching by super-lubricant van der Waals cavity arrays AI翻译
  作者：Yeo, Youngki; Sharaby, Yoav; Roy, Nirmal; Raab, Noam; Watanabe, Kenji; Taniguchi, Takashi; Ben Shalom, Moshe
  作者单位：Tel Aviv University; National Institute for Materials Science; National Institute for Materials Science
  摘要：Expanding the performance of field-effect devices is a key challenge of the ever-growing chip industry at the core of current technologies1. Non-volatile multiferroic transistors that control atomic movements rather than purely electronic distribution are highly desired2. Recently, a field-effect control over structural transitions was achieved in commensurate stacking configurations of honeycomb van der Waals (vdW) polytypes by sliding boundary strips between oppositely polarized domains3, 4,...