作者：Lan, Feng; Li, Jizhou; Miao, Wenxuan; Sun, Fei; Duan, Su; Song, Yabing; Yao, Jiacheng; Wang, Xiangdong; Wang, Chengshuo; Liu, Xin; Wang, Jianbin; Zhang, Luo; Qi, Hai
作者单位：Capital Medical University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Capital Medical University; Changping Laboratory; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Shanxi Medical University
摘要：Inflammatory diseases are often chronic and recurrent, and current treatments do not typically remove underlying disease drivers1. T cells participate in a wide range of inflammatory diseases such as psoriasis2, Crohn's disease3, oesophagitis4 and multiple sclerosis5,6, and clonally expanded antigen-specific T cells may contribute to disease chronicity and recurrence, in part by forming persistent pathogenic memory. Chronic rhinosinusitis and asthma are inflammatory airway diseases that often ...
作者：Stokes, Eric G.; Vasquez, Jose J.; Azouz, Ghalia; Nguyen, Megan; Tierno, Alexa; Zhuang, Yinyin; Galinato, Vivienne Mae; Hui, May; Toledano, Michael; Tyler, Isabella; Shi, Xiaoyu; Hunt, Robert F.; Aoto, Jason; Beier, Kevin T.
作者单位：University of Colorado System; University of Colorado Anschutz Medical Campus; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of Colorado System; University of Colorado Anschutz Medical Campus; University of California System; University of California Irvine; University of California System; University of California Irvine
摘要：The zeta inhibitory peptide (ZIP) interferes with memory maintenance and long-term potentiation (LTP)(1) when administered to mice. However, mice lacking its putative target, protein kinase PKM zeta, exhibit normal learning and memory as well as LTP2,3, making the mechanism of ZIP unclear. Here we show that ZIP disrupts LTP by removing surface AMPA receptors through its cationic charge alone. This effect requires endophilin-A2-mediated endocytosis and is fully blocked by drugs suppressing macr...
作者：Audard, Marc; Awaki, Hisamitsu; Ballhausen, Ralf; Bamba, Aya; Behar, Ehud; Boissay-Malaquin, Rozenn; Brenneman, Laura; Brown, Gregory V.; Corrales, Lia; Costantini, Elisa; Cumbee, Renata; Done, Chris; Dotani, Tadayasu; Ebisawa, Ken; Eckart, Megan E.; Eckert, Dominique; Enoto, Teruaki; Eguchi, Satoshi; Ezoe, Yuichiro; Foster, Adam; Fujimoto, Ryuichi; Fujita, Yutaka; Fukazawa, Yasushi; Fukushima, Kotaro; Furuzawa, Akihiro; Gallo, Luigi; Garcia, Javier A.; Gu, Liyi; Guainazzi, Matteo; Hagino, Kouichi; Hamaguchi, Kenji; Hatsukade, Isamu; Hayashi, Katsuhiro; Hayashi, Takayuki; Hell, Natalie; Hodges-Kluck, Edmund; Hornschemeier, Ann; Ichinohe, Yuto; Ishida, Manabu; Ishikawa, Kumi; Ishisaki, Yoshitaka; Kaastra, Jelle; Kallman, Timothy; Kara, Erin; Katsuda, Satoru; Kanemaru, Yoshiaki; Kelley, Richard; Kilbourne, Caroline; Kitamoto, Shunji; Kobayashi, Shogo; Kohmura, Takayoshi; Kubota, Aya; Leutenegger, Maurice; Loewenstein, Michael; Maeda, Yoshitomo; Markevitch, Maxim; Matsumoto, Hironori; Matsushita, Kyoko; McCammon, Dan; McNamara, Brian; Mernier, Francois; Miller, Eric D.; Miller, Jon M.; Mitsuishi, Ikuyuki; Mizumoto, Misaki; Mizuno, Tsunefumi; Mori, Koji; Mukai, Koji; Murakami, Hiroshi; Mushotzky, Richard; Nakajima, Hiroshi; Nakazawa, Kazuhiro; Ness, Jan-Uwe; Nobukawa, Kumiko; Nobukawa, Masayoshi; Noda, Hirofumi; Odaka, Hirokazu; Ogawa, Shoji; Ogorzalek, Anna; Okajima, Takashi; Ota, Naomi; Paltani, Stephane; Petre, Robert; Plucinsky, Paul; Porter, Frederick Scott; Pottschmidt, Katja; Sato, Kosuke; Sato, Toshiki; Sawada, Makoto; Seta, Hiromi; Shidatsu, Megumi; Simionescu, Aurora; Smith, Randall; Suzuki, Hiromasa; Szymkowiak, Andrew; Takahashi, Hiromitsu; Takeo, Mai; Tamagawa, Toru; Tamura, Keisuke; Tanaka, Takaaki; Tanimoto, Atsushi; Tashiro, Makoto; Terada, Yukikatsu; Terashima, Yuichi; Trigo, Maria Diaz; Tsuboi, Yohko; Tsujimoto, Masahiro; Tsunemi, Hiroshi; Tsuru, Takeshi G.; Uchida, Hiroyuki; Uchida, Nagomi; Uchida, Yuusuke; Uchiyama, Hideki; Ueda, Yoshihiro; Uno, Shinichiro; Vink, Jacco; Watanabe, Shin; Williams, Brian J.; Yamada, Satoshi; Yamada, Shinya; Yamaguchi, Hiroya; Yamaoka, Kazutaka; Yamasaki, Noriko Y.; Yamauchi, Makoto; Yamauchi, Shigeo; Yaqoob, Tahir; Yoneyama, Tomokage; Yoshida, Tessei; Yukita, Mihoko; Zhuravleva, Irina; Kondo, Marie; Werner, Norbert; Plsek, Tomas; Sun, Ming; Hosogi, Kokoro; Majumder, Anwesh
作者单位：University of Geneva; Ehime University; University System of Maryland; University of Maryland College Park; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University of Tokyo; Technion Israel Institute of Technology; University System of Maryland; University of Maryland Baltimore County; Harvard University; Smithsonian Institution; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; University of Michigan System; University of Michigan; Durham University; Japan Aerospace Exploration Agency (JAXA); Institute of Space & Astronautical Science (ISAS); Kyoto University; Tokyo Metropolitan University; Hiroshima University; Fujita Health University; Saint Marys University - Canada; California Institute of Technology; European Space Agency; European Space Research & Technology Centre; University of Miyazaki; RIKEN; Leiden University; Leiden University - Excl LUMC; Massachusetts Institute of Technology (MIT); Saitama University; Rikkyo University; Tokyo University of Science; Tokyo University of Science; Shibaura Institute of Technology; University of Osaka; University of Wisconsin System; University of Wisconsin Madison; University of Waterloo; Nagoya University; Hiroshima University; Tohoku Gakuin University; Kanto Gakuin University; European Space Agency; European Space Astronomy Center; Kindai University (Kinki University); Nara University Education; Tohoku University; Nara Womens University; High Energy Accelerator Research Organization (KEK); Meiji University; Yale University; Konan University; Kagoshima University; Chuo University; Shizuoka University; Kyoto University; University of Amsterdam; RIKEN; Johns Hopkins University; University of Chicago; Masaryk University; University of Alabama System; University of Alabama Huntsville; University of Amsterdam
摘要：Galaxy clusters contain vast amounts of hot ionized gas known as the intracluster medium (ICM). In relaxed cluster cores, the radiative cooling time of the ICM is shorter than the age of the cluster. However, the absence of line emission associated with cooling suggests heating mechanisms that offset the cooling, with feedback from active galactic nuclei (AGNs) being the most likely source(1,2). Turbulence and bulk motions, such as the oscillating ('sloshing') motion of the core gas in the clu...
