8050期

最新文章

• Signs of damage that drive protein degradation AI翻译
  作者：Freeberg, Alfred; Rape, Michael
  作者单位：University of California System; University of California Berkeley; Howard Hughes Medical Institute; University of California System; University of California Berkeley; University of California System; University of California Berkeley
• C-terminal amides mark proteins for degradation via SCF-FBXO31 AI翻译
  作者：Muhar, Matthias F.; Farnung, Jakob; Cernakova, Martina; Hofmann, Raphael; Henneberg, Lukas T.; Pfleiderer, Moritz M.; Denoth-Lippuner, Annina; Kalcic, Filip; Nievergelt, Ajse S.; Peters Al-Bayati, Marwa; Sidiropoulos, Nikolaos D.; Beier, Viola; Mann, Matthias; Jessberger, Sebastian; Jinek, Martin; Schulman, Brenda A.; Bode, Jeffrey W.; Corn, Jacob E.
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Max Planck Society; University of Zurich; University of Zurich; Max Planck Society
  摘要：During normal cellular homeostasis, unfolded and mislocalized proteins are recognized and removed, preventing the build-up of toxic byproducts1. When protein homeostasis is perturbed during ageing, neurodegeneration or cellular stress, proteins can accumulate several forms of chemical damage through reactive metabolites2,3. Such modifications have been proposed to trigger the selective removal of chemically marked proteins3, 4, 5-6; however, identifying modifications that are sufficient to ind...
• Regional and institutional trends in assessment for academic promotion AI翻译
  作者：Lim, B. H.; D'Ippoliti, C.; Dominik, M.; Hernandez-Mondragon, A. C.; Vermeir, K.; Chong, K. K.; Hussein, H.; Morales-Salgado, V. S.; Cloete, K. J.; Kimengsi, J. N.; Balboa, L.; Mondello, S.; dela Cruz, T. E.; Lopez-Verges, S.; Sidi Zakari, I.; Simonyan, A.; Palomo, I.; Rezek Jambrak, A.; Germo Nzweundji, J.; Molnar, A.; Saktiawati, A. M. I.; Elagroudy, S.; Kumar, P.; Enany, S.; Narita, V.; Backes, M.; Siciliano, V.; Egamberdieva, D.; Flores Bueso, Y.
  作者单位：Universiti Tunku Abdul Rahman (UTAR); Sapienza University Rome; University of St Andrews; CINVESTAV - Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional; Instituto Politecnico Nacional - Mexico; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS); Universite Paris Cite; University of Oxford; University of South Africa; National Research Foundation - South Africa; iThemba LABS; Technische Universitat Dresden; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Buenos Aires National Academy of Medicine; IMEX - Instituto de Medicina Experimental; University of Messina; University of Santo Tomas; Instituto Conmemorativo Gorgas de Estudios de la Salud; Secretaria Nacional de Ciencia, Tecnologia e Innovacin (SENACYT); Abdou Moumouni University; University of Sussex; Institut de Recherche pour le Developpement (IRD); Communaute Universite Grenoble Alpes; Institut National Polytechnique de Grenoble; INRAE; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); University of Zagreb; Swinburne University of Technology; Technical University of Munich; Gadjah Mada University; Egyptian Knowledge Bank (EKB); Ain Shams University; University of Witwatersrand; Egyptian Knowledge Bank (EKB); Suez Canal University; University of Namibia; North West University - South Africa; Istituto Italiano di Tecnologia - IIT; Tashkent Institute of Irrigation & Agricultural Mechanization Engineers; National University of Uzbekistan; University College Cork; University of Washington; University of Washington Seattle
  摘要：The assessment of research performance is widely seen as a vital tool in upholding the highest standards of quality, with selection and competition believed to drive progress. Academic institutions need to take critical decisions on hiring and promotion, while facing external pressure by also being subject to research assessment1, 2, 3-4. Here we present an outlook on research assessment for career progression with specific focus on promotion to full professorship, based on 314 policies from 1...
• Gliomagenesis mimics an injury response orchestrated by neural crest-like cells AI翻译
  作者：Hamed, Akram A.; Hua, Kui; Trinh, Quang M.; Simons, Benjamin D.; Marioni, John C.; Stein, Lincoln D.; Dirks, Peter B.
  作者单位：University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Hospital for Sick Children (SickKids); CRUK Cambridge Institute; Cancer Research UK; University of Cambridge; Ontario Institute for Cancer Research; University of Toronto; European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; Wellcome Trust Sanger Institute; University of Cambridge; University of Cambridge; University of Toronto
  摘要：Glioblastoma is an incurable brain malignancy. By the time of clinical diagnosis, these tumours exhibit a degree of genetic and cellular heterogeneity that provides few clues to the mechanisms that initiate and drive gliomagenesis1,2. Here, to explore the early steps in gliomagenesis, we utilized conditional gene deletion and lineage tracing in tumour mouse models, coupled with serial magnetic resonance imaging, to initiate and then closely track tumour formation. We isolated labelled and unla...
• The science behind the first pig-organ transplant trial in humans AI翻译
  作者：Mallapaty, Smriti; Kozlov, Max
• Transforming US agriculture for carbon removal with enhanced weathering AI翻译
  作者：Beerling, David J.; Kantzas, Euripides P.; Lomas, Mark R.; Taylor, Lyla L.; Zhang, Shuang; Kanzaki, Yoshiki; Eufrasio, Rafael M.; Renforth, Phil; Mecure, Jean-Francois; Pollitt, Hector; Holden, Philip B.; Edwards, Neil R.; Koh, Lenny; Epihov, Dimitar Z.; Wolf, Adam; Hansen, James E.; Banwart, Steven A.; Pidgeon, Nick F.; Reinhard, Christopher T.; Planavsky, Noah J.; Val Martin, Maria
  作者单位：University of Sheffield; Texas A&M University System; Texas A&M University College Station; University System of Georgia; Georgia Institute of Technology; University of Sheffield; Heriot Watt University; University of Exeter; University of Cambridge; The World Bank; Open University - UK; Princeton University; Columbia University; University of Leeds; Cardiff University; Yale University
  摘要：Enhanced weathering (EW) with agriculture uses crushed silicate rocks to drive carbon dioxide removal (CDR)1,2. If widely adopted on farmlands, it could help achieve net-zero emissions by 20502, 3-4. Here we show, with a detailed US state-specific carbon cycle analysis constrained by resource provision, that EW deployed on agricultural land could sequester 0.16-0.30 GtCO2 yr-1 by 2050, rising to 0.25-0.49 GtCO2 yr-1 by 2070. Geochemical assessment of rivers and oceans suggests effective transp...
• Viral tolerance enabled by a bat-specific genomic tweak AI翻译
  作者：Zhu, Junji; Gack, Michaela U.
  作者单位：Cleveland Clinic Foundation
• Geological Net Zero and the need for disaggregated accounting for carbon sinks AI翻译
  作者：Allen, Myles R.; Frame, David J.; Friedlingstein, Pierre; Gillett, Nathan P.; Grassi, Giacomo; Gregory, Jonathan M.; Hare, William; House, Jo; Huntingford, Chris; Jenkins, Stuart; Jones, Chris D.; Knutti, Reto; Lowe, Jason A.; Matthews, H. Damon; Meinshausen, Malte; Meinshausen, Nicolai; Peters, Glen P.; Plattner, Gian-Kasper; Raper, Sarah; Rogelj, Joeri; Stott, Peter A.; Solomon, Susan; Stocker, Thomas F.; Weaver, Andrew J.; Zickfeld, Kirsten
  作者单位：University of Oxford; University of Oxford; University of Canterbury; University of Exeter; European Commission Joint Research Centre; EC JRC ISPRA Site; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC National Centre for Atmospheric Science; University of Reading; Met Office - UK; University of Bristol; UK Centre for Ecology & Hydrology (UKCEH); Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Leeds; Concordia University - Canada; University of Melbourne; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Manchester Metropolitan University; Imperial College London; University of Exeter; Massachusetts Institute of Technology (MIT); University of Bern; University of Victoria; Simon Fraser University
  摘要：Achieving net-zero global emissions of carbon dioxide (CO2), with declining emissions of other greenhouse gases, is widely expected to halt global warming. CO2 emissions will continue to drive warming until fully balanced by active anthropogenic CO2 removals. For practical reasons, however, many greenhouse gas accounting systems allow some 'passive' CO2 uptake, such as enhanced vegetation growth owing to CO2 fertilization, to be included as removals in the definition of net anthropogenic emiss...
• Earliest short-tailed bird from the Late Jurassic of China AI翻译
  作者：Chen, Runsheng; Wang, Min; Dong, Liping; Zhou, Guowu; Xu, Xing; Deng, Ke; Xu, Liming; Zhang, Chi; Wang, Linchang; Du, Honggang; Lin, Ganmin; Lin, Min; Zhou, Zhonghe
  作者单位：Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS
  摘要：Recent macroevolutionary studies predict a diversification of early birds during the Jurassic period1, 2, 3-4, but the unquestionable Jurassic bird fossil record is limited to Archaeopteryx1,5,6, which has also been referred to deinonychosaurian dinosaurs by some analyses7,8. Although they have feathered wings, the known Jurassic birds are more similar to non-avialan theropods in having the ancestral long reptilian tail9, 10-11. This is in stark contrast to most Cretaceous and crownward taxa, ...
• Observation of an ultra-high-energy cosmic neutrino with KM3NeT AI翻译
  作者：Aiello, S.; Albert, A.; Alhebsi, A. R.; Alshamsi, M.; Garre, S. Alves; Ambrosone, A.; Ameli, F.; Andre, M.; Anghinolfi, M.; Aphecetche, L.; Ardid, M.; Ardid, S.; Arguelles, C.; Atmani, H.; Aublin, J.; Badaracco, F.; Bailly-Salins, L.; Bardacova, Z.; Baret, B.; Bariego-Quintana, A.; Becherini, Y.; Bendahman, M.; Gualandi, F. Benfenati; Benhassi, M.; Bennani, M.; Benoit, D. M.; Berbee, E.; Bertin, V.; Biagi, S.; Boettcher, M.; Bonanno, D.; Bouasla, A. B.; Boumaaza, J.; Bouta, M.; Bouwhuis, M.; Bozza, C.; Bozza, R. M.; Branzas, H.; Bretaudeau, F.; Breuhaus, M.; Bruijn, R.; Brunner, J.; Bruno, R.; Buis, E.; Buompane, R.; Buson, S.; Busto, J.; Caiffi, B.; Calvo, D.; Capone, A.; Carenini, F.; Carretero, V.; Cartraud, T.; Castaldi, P.; Cecchini, V.; Celli, S.; Cerisy, L.; Chabab, M.; Chen, A.; Cherubini, S.; Chiarusi, T.; Circella, M.; Cocimano, R.; Coelho, J. A. B.; Coleiro, A.; Colonges, S.; Condorelli, A.; Coniglione, R.; Coyle, P.; Creusot, A.; Cuttone, G.; D'Amico, A.; Dallier, R.; De Benedittis, A.; De Martino, B.; De Wasseige, G.; Decoene, V.; Del Rosso, I.; Di Mauro, L. S.; Di Palma, I.; Diaz, A. F.; Diego-Tortosa, D.; Distefano, C.; Domi, A.; Donzaud, C.; Dornic, D.; Drakopoulou, E.; Drouhin, D.; Ducoin, J. -G.; Dvornicky, R.; Eberl, T.; Eckerova, E.; Eddymaoui, A.; van Eeden, T.; Eff, M.; van Eijk, D.; El Bojaddaini, I.; El Hedri, S.; Ellajosyula, V.; Enzenhofer, A.; Ferrara, G.; Filipovicv, M. D.; Filippini, F.; Franciotti, D.; Fusco, L. A.; Gagliardini, S.; Gal, T.; Mendez, J. Garcia; Soto, A. Garcia; Oliver, C. Gatius; Geisselbrecht, N.; Genton, E.; Ghaddari, H.; Gialanella, L.; Gibson, B. K.; Giorgio, E.; Goos, I.; Goswami, P.; Gozzini, S. R.; Gracia, R.; Graf, K.; Guidi, C.; Guillon, B.; Gutierrez, M.; Haack, C.; van Haren, H.; Heijboer, A.; Hennig, L.; Henry, S.; Hernandez-Rey, J. J.; Ibnsalih, W. Idrissi; Ilioni, A.; Illuminati, G.; Joly, D.; de Jong, M.; de Jong, P.; Jung, B. J.; Kalaczynski, P.; Kalekin, O.; Kamp, N.; Katz, U. F.; Kistauri, G.; Kopper, C.; Kouchner, A.; Kovalev, Y. Y.; Kueviakoe, V.; Kulikovskiy, V.; Kvatadze, R.; Labalme, M.; Lahmann, R.; Lamoureux, M.; Lancelin, S.; Larosa, G.; Lastoria, C.; Lazar, J.; Lazo, A.; Le Stum, S.; Lehaut, G.; Lemaitre, V.; Leonora, E.; Lessing, N.; Levi, G.; Lincetto, M.; Clark, M. Lindsey; Longhitano, F.; Lumb, N.; Magnani, F.; Majumdar, J.; Malerba, L.; Mamedov, F.; Manfreda, A.; Marconi, M.; Margiotta, A.; Marinelli, A.; Markou, C.; Martin, L.; Marzaioli, F.; Mastrodicasa, M.; Mastroianni, S.; Mauro, J.; Miele, G.; Migliozzi, P.; Migneco, E.; Mitsou, M. L.; Mollo, C. M.; Mongelli, M.; Morales-Gallegos, L.; Moussa, A.; Mateo, I. Mozun; Muller, R.; Musone, M. R.; Musumeci, M.; Navas, S.; Nayerhoda, A.; Nicolau, C. A.; Nkosi, B.; Fearraigh, B. O.; Oliviero, V.; Orlando, A.; Oukacha, E.; Paesani, D.; Gonzalez, J. Palacios; Papalashvili, G.; Paries, C.; Parisi, V.; Gomez, E. J. Pastor; Pastore, C.; Paun, A. M.; Pavalas, G. E.; Martinez, S. Pena; Perrin-Terrin, M.; Pestel, V.; Pestes, R.; Pfeiffer, L.; Piattelli, P.; Plavin, A.; Poire, C.; Popa, V.; Pradier, T.; Prado, J.; Pulvirenti, S.; Quiroz-Rangel, C. A.; Randazzo, N.; Razzaque, S.; Rea, I. C.; Real, D.; Riccobene, G.; Robinson, J.; Romanov, A.; Ros, E.; Saina, A.; Greus, F. Salesa; Samtleben, D. F. E.; Losa, A. Sanchez; Sanfilippo, S.; Sanguineti, M.; Santonocito, D.; Sapienza, P.; Schmelling, J.; Schnabel, J.; Schumann, J.; Schutte, H. M.; Seneca, J.; Sennan, N.; Sevle, P.; Sgura, I.; Shanidze, R.; Sharma, A.; Shitov, Y.; Simkovic, F.; Simonelli, A.; Sinopoulou, A.; Spisso, B.; Spurio, M.; Stavropoulos, D.; Stekl, I.; Taiuti, M.; Tayalati, Y.; Thiersen, H.; Thoudam, S.; Tosta e Melo, I.; Trocme, B.; Tsourapis, V.; Tudorache, A.; Tzamariudaki, E.; Ukleja, A.; Vacheret, A.; Valsecchi, V.; van Elewyck, V.; Vannoye, G.; Vasileiadis, G.; de Sola, F. Vazquez; Verilhac, C.; Veutro, A.; Viola, S.; Vivolo, D.; van Vliet, A.; Wen, A. Y.; de Wolf, E.; Lhenry-Yvon, I.; Zavatarelli, S.; Zegarelli, A.; Zito, D.; Zornoza, J. D.; Zuniga, J.; Zywucka, N.
  作者单位：Istituto Nazionale di Fisica Nucleare (INFN); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute of Nuclear and Particle Physics (IN2P3); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Universites de Strasbourg Etablissements Associes; Universite de Haute-Alsace (UHA); Khalifa University of Science & Technology; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute of Nuclear and Particle Physics (IN2P3); Aix-Marseille Universite; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Fisica Corpuscular (IFIC); University of Valencia; Istituto Nazionale di Fisica Nucleare (INFN); University of Naples Federico II; Istituto Nazionale di Fisica Nucleare (INFN); Universitat Politecnica de Catalunya; Istituto Nazionale di Fisica Nucleare (INFN); Nantes Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute of Nuclear and Particle Physics (IN2P3); IMT - Institut Mines-Telecom; IMT Atlantique; Universitat Politecnica de Valencia; Harvard University; Harvard University; Mohammed V University in Rabat; Universite PSL; Observatoire de Paris; CEA; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; University of Genoa; Universite de Caen Normandie; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute of Nuclear and Particle Physics (IN2P3); Czech Technical University Prague; Comenius University Bratislava; Istituto Nazionale di Fisica Nucleare (INFN); University of Bologna; Universita della Campania Vanvitelli; University of Hull; FOM National Institute for Subatomic Physics; Istituto Nazionale di Fisica Nucleare (INFN); North West University - South Africa; Universite Badji Mokhtar - Annaba; Mohammed V University in Rabat; Mohammed First University of Oujda; University of Salerno; Istituto Nazionale di Fisica Nucleare (INFN); University of Amsterdam; Netherlands Organization Applied Science Research; Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); University of Wurzburg; Sapienza University Rome; University of Bologna; Cadi Ayyad University of Marrakech; University of Witwatersrand; University of Catania; Istituto Nazionale di Fisica Nucleare (INFN); Istituto Nazionale di Fisica Nucleare (INFN); Universite Catholique Louvain; University of Granada; University of Erlangen Nuremberg; National Centre of Scientific Research Demokritos; Western Sydney University; University of Granada; University of Granada; Utrecht University; Royal Netherlands Institute for Sea Research (NIOZ); Leiden University; Leiden University - Excl LUMC; Polish Academy of Sciences; Nicolaus Copernicus Astronomical Center of the Polish Academy of Sciences; AGH University of Krakow; Ivane Javakhishvili Tbilisi State University; Institut Universitaire de France; Max Planck Society; Harvard University; University of Johannesburg; Mohammed VI Polytechnic University; National Centre for Nuclear Research; Universite de Montpellier
  摘要：The detection of cosmic neutrinos with energies above a teraelectronvolt (TeV) offers a unique exploration into astrophysical phenomena(1-3). Electrically neutral and interacting only by means of the weak interaction, neutrinos are not deflected by magnetic fields and are rarely absorbed by interstellar matter: their direction indicates that their cosmic origin might be from the farthest reaches of the Universe. High-energy neutrinos can be produced when ultra-relativistic cosmic-ray protons o...