8051期

最新文章

• Migraine is more than a headache - a radical rethink offers hope to one billion people AI翻译
  作者：Schwaller, Fred
• A sustainable ocean needs thriving ocean societies AI翻译
  作者：Claudet, Joachim; Blythe, Jessica; Gill, David
  作者单位：Centre National de la Recherche Scientifique (CNRS); Brock University; Duke University
• Researchers overlooked airborne diseases for centuries - then COVID-19 changed everything AI翻译
  作者：Marr, Linsey C.
  作者单位：Virginia Polytechnic Institute & State University
• Spontaneous ordering of identical materials into a triboelectric series AI翻译
  作者：Sobarzo, Juan Carlos; Pertl, Felix; Balazs, Daniel M.; Costanzo, Tommaso; Sauer, Markus; Foelske, Annette; Ostermann, Markus; Pichler, Christian M.; Wang, Yongkang; Nagata, Yuki; Bonn, Mischa; Waitukaitis, Scott
  作者单位：Institute of Science & Technology - Austria; Technische Universitat Wien; Max Planck Society
  摘要：When two insulating, neutral materials are contacted and separated, they exchange electrical charge1. Experiments have long suggested that this 'contact electrification' is transitive, with different materials ordering into 'triboelectric series' based on the sign of charge acquired2. At the same time, the effect is plagued by unpredictability, preventing consensus on the mechanism and casting doubt on the rhyme and reason that series imply3. Here we expose an unanticipated connection between ...
• Aqueous-based recycling of perovskite photovoltaics AI翻译
  作者：Xiao, Xun; Xu, Niansheng; Tian, Xueyu; Zhang, Tiankai; Wang, Bingzheng; Wang, Xiaoming; Xian, Yeming; Lu, Chunyuan; Ou, Xiangyu; Yan, Yanfa; Sun, Licheng; You, Fengqi; Gao, Feng
  作者单位：Linkoping University; Cornell University; University System of Ohio; University of Toledo; University System of Ohio; University of Toledo; Westlake University; Westlake University; Westlake University; Baima Lake Laboratory; Cornell University; Cornell University; Linkoping University
  摘要：Cumulative silicon photovoltaic (PV) waste highlights the importance of considering waste recycling before the commercialization of emerging PV technologies1,2. Perovskite PVs are a promising next-generation technology3, in which recycling their end-of-life waste can reduce the toxic waste and retain resources4,5. Here we report a low-cost, green-solvent-based holistic recycling strategy to restore all valuable components from perovskite PV waste. We develop an efficient aqueous-based perovski...
• Engineered receptors for soluble cellular communication and disease sensing AI翻译
  作者：Piraner, Dan I.; Abedi, Mohamad H.; Duran Gonzalez, Maria J.; Chazin-Gray, Adam; Lin, Annie; Zhu, Iowis; Ravindran, Pavithran T.; Schlichthaerle, Thomas; Huang, Buwei; Bearchild, Tyler H.; Lee, David; Wyman, Sarah; Jun, Young-wook; Baker, David; Roybal, Kole T.
  作者单位：University of California System; University of California San Francisco; University of Washington; University of Washington Seattle; University of California System; University of California San Francisco; University of California System; University of California Berkeley; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; Chan Zuckerberg Initiative (CZI); University of Pennsylvania
  摘要：Despite recent advances in mammalian synthetic biology, there remains a lack of modular synthetic receptors that can robustly respond to soluble ligands and, in turn, activate bespoke cellular functions. Such receptors would have extensive clinical potential to regulate the activity of engineered therapeutic cells, but so far only receptors against cell-surface targets have approached clinical translation1. To address this gap, here we adapt a receptor architecture called the synthetic intrame...
• Atlantic oceanic droughts do not threaten Asian water tower AI翻译
  作者：Zhao, Yutong; Xu, Chaoyi; Yu, Xiaoyu; Liu, Yigang; Ji, Xinhui
  作者单位：Chinese Academy of Sciences; Institute of Tibetan Plateau Research, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
• Multiscale footprints reveal the organization of cis-regulatory elements AI翻译
  作者：Hu, Yan; Horlbeck, Max A.; Zhang, Ruochi; Ma, Sai; Shrestha, Rojesh; Kartha, Vinay K.; Duarte, Fabiana M.; Hock, Conrad; Savage, Rachel E.; Labade, Ajay; Kletzien, Heidi; Meliki, Alia; Castillo, Andrew; Durand, Neva C.; Mattei, Eugenio; Anderson, Lauren J.; Tay, Tristan; Earl, Andrew S.; Shoresh, Noam; Epstein, Charles B.; Wagers, Amy J.; Buenrostro, Jason D.
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Icahn School of Medicine at Mount Sinai
  摘要：Cis-regulatory elements (CREs) control gene expression and are dynamic in their structure and function, reflecting changes in the composition of diverse effector proteins over time1. However, methods for measuring the organization of effector proteins at CREs across the genome are limited, hampering efforts to connect CRE structure to their function in cell fate and disease. Here we developed PRINT, a computational method that identifies footprints of DNA-protein interactions from bulk and sin...
• Earliest modern human genomes constrain timing of Neanderthal admixture AI翻译
  作者：Suemer, Arev P.; Rougier, Helene; Villalba-Mouco, Vanessa; Huang, Yilei; Iasi, Leonardo N. M.; Essel, Elena; Mesa, Alba Bossoms; Furtwaengler, Anja; Peyregne, Stephane; de Filippo, Cesare; Rohrlach, Adam B.; Pierini, Federica; Mafessoni, Fabrizio; Fewlass, Helen; Zavala, Elena I.; Mylopotamitaki, Dorothea; Bianco, Raffaela A.; Schmidt, Anna; Zorn, Julia; Nickel, Birgit; Patova, Anna; Posth, Cosimo; Smith, Geoff M.; Ruebens, Karen; Sinet-Mathiot, Virginie; Stoessel, Alexander; Dietl, Holger; Orschiedt, Joerg; Kelso, Janet; Zeberg, Hugo; Bos, Kirsten I.; Welker, Frido; Weiss, Marcel; Mcpherron, Shannon P.; Schueler, Tim; Hublin, Jean-Jacques; Veleminsky, Petr; Bruzek, Jaroslav; Peter, Benjamin M.; Meyer, Matthias; Meller, Harald; Ringbauer, Harald; Hajdinjak, Mateja; Pruefer, Kay; Krause, Johannes
  作者单位：Max Planck Society; California State University System; California State University Northridge; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); Pompeu Fabra University; Leipzig University; University of Adelaide; Tel Aviv University; Francis Crick Institute; University of Bristol; University of California System; University of California Berkeley; Universite PSL; College de France; Eberhard Karls University of Tubingen; University of Reading; Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Friedrich Schiller University of Jena; Free University of Berlin; Karolinska Institutet; University of Copenhagen; University of Erlangen Nuremberg; National Museum; Charles University Prague; University of Rochester
  摘要：Modern humans arrived in Europe more than 45,000 years ago, overlapping at least 5,000 years with Neanderthals1, 2, 3-4. Limited genomic data from these early modern humans have shown that at least two genetically distinct groups inhabited Europe, represented by Zlat & yacute; k & uring;& ncaron;, Czechia3 and Bacho Kiro, Bulgaria2. Here we deepen our understanding of early modern humans by analysing one high-coverage genome and five low-coverage genomes from approximately 45,000-year-old rema...
• Expanding the human gut microbiome atlas of Africa AI翻译
  作者：Maghini, Dylan G.; Oduaran, Ovokeraye H.; Olubayo, Luicer A. Ingasia; Cook, Jane A.; Smyth, Natalie; Mathema, Theophilous; Belger, Carl W.; Agongo, Godfred; Boua, Palwende R.; Choma, Solomon S. R.; Gomez-Olive, F. Xavier; Kisiangani, Isaac; Mashaba, Given R.; Micklesfield, Lisa; Mohamed, Shukri F.; Nonterah, Engelbert A.; Norris, Shane; Sorgho, Hermann; Tollman, Stephen; Wafawanaka, Floidy; Tluway, Furahini; Ramsay, Michele; Wirbel, Jakob; Bhatt, Ami S.; Hazelhurst, Scott
  作者单位：University of Witwatersrand; Stanford University; Stanford University; University of Witwatersrand; Navrongo Health Research Center; University of Limpopo; University of Witwatersrand; African Population & Health Research Centre; University of Witwatersrand; University of Southampton; Stanford University; University of Witwatersrand
  摘要：Population studies provide insights into the interplay between the gut microbiome and geographical, lifestyle, genetic and environmental factors. However, low- and middle-income countries, in which approximately 84% of the world's population lives1, are not equitably represented in large-scale gut microbiome research2, 3-4. Here we present the AWI-Gen 2 Microbiome Project, a cross-sectional gut microbiome study sampling 1,801 women from Burkina Faso, Ghana, Kenya and South Africa. By engaging ...