8051期

最新文章

• 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark (Expression of Concern of 10.1038/NATURE12318) AI翻译
  作者：Fradet-Turcotte, Amelie; Canny, Marella D.; Escribano-Diaz, Cristina; Orthwein, Alexandre; Leung, Charles C. Y.; Huang, Hao; Landry, Marie-Claude; Kitevski-LeBlanc, Julianne; Noordermeer, Sylvie M.; Sicheri, Frank; Durocher, Daniel
• The structure of bad cholesterol comes into focus AI翻译
  作者：Davidson, W. Sean
• Structure of apolipoprotein B100 bound to the low-density lipoprotein receptor AI翻译
  作者：Reimund, Mart; Dearborn, Altaira D.; Graziano, Giorgio; Lei, Haotian; Ciancone, Anthony M.; Kumar, Ashish; Holewinski, Ronald; Neufeld, Edward B.; O'Reilly, Francis J.; Remaley, Alan T.; Marcotrigiano, Joseph
  作者单位：National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research
  摘要：Apolipoprotein B100 (apoB100) is a structural component of low-density lipoprotein (LDL) and a ligand for the LDL receptor (LDLR)1. Mutations in apoB100 or in LDLR cause familial hypercholesterolaemia, an autosomal dominant disease that is characterized by a marked increase in LDL cholesterol (LDL-C) and a higher risk of cardiovascular disease2. The structure of apoB100 on LDL and its interaction with LDLR are poorly understood. Here we present the cryo-electron microscopy structures of apoB10...
• A man was destined for early Alzheimer's - these genes might explain his escape AI翻译
  作者：Reardon, Sara
• Direct experimental constraints on the spatial extent of a neutrino wavepacket AI翻译
  作者：Smolsky, Joseph; Leach, Kyle G.; Abells, Ryan; Amaro, Pedro; Andoche, Adrien; Borbridge, Keith; Bray, Connor; Cantor, Robin; Diercks, David; Fretwell, Spencer; Friedrich, Stephan; Gillespie, Abigail; Guerra, Mauro; Hall, Ad; Harris, Cameron N.; Harris, Jackson T.; Hayen, Leendert M.; Hervieux, Paul-Antoine; Hinkle, Calvin; Kim, Geon-Bo; Kim, Inwook; Lamm, Amii; Lennarz, Annika; Lordi, Vincenzo; Machado, Jorge; Marino, Andrew; Mckeen, David; Mougeot, Xavier; Ponce, Francisco; Ruiz, Chris; Samanta, Amit; Santos, Jose Paulo; Stone-Whitehead, Caitlyn; Taylor, John; Templet, Joseph; Upadhyayula, Sriteja; Wagner, Louis; Warburton, William K.
  作者单位：Colorado School of Mines; Michigan State University; University of British Columbia; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Colorado School of Mines; Universite de Caen Normandie; McMaster University; Universite Paris Saclay; CEA; United States Department of Energy (DOE); Pacific Northwest National Laboratory
  摘要：Despite their high relative abundance in our Universe, neutrinos are the least understood fundamental particles of nature. In fact, the quantum properties of neutrinos emitted in experimentally relevant sources are theoretically contested1, 2, 3-4 and the spatial extent of the neutrino wavepacket is only loosely constrained by reactor neutrino oscillation data with a spread of 13 orders of magnitude5,6. Here we present a method to directly access this quantity by precisely measuring the energy...
• World and Human Action Models towards gameplay ideation AI翻译
  作者：Kanervisto, Anssi; Bignell, Dave; Wen, Linda Yilin; Grayson, Martin; Georgescu, Raluca; Macua, Sergio Valcarcel; Tan, Shan Zheng; Rashid, Tabish; Pearce, Tim; Cao, Yuhan; Lemkhenter, Abdelhak; Jiang, Chentian; Costello, Gavin; Gupta, Gunshi; Tot, Marko; Ishida, Shu; Gupta, Tarun; Arora, Udit; White, Ryen W.; Devlin, Sam; Morrison, Cecily; Hofmann, Katja
  作者单位：Microsoft; Microsoft United Kingdom; University of Edinburgh; University of Oxford; University of London; Queen Mary University London; Microsoft
  摘要：Generative artificial intelligence (AI) has the potential to transform creative industries through supporting human creative ideation-the generation of new ideas1, 2, 3, 4-5. However, limitations in model capabilities raise key challenges in integrating these technologies more fully into creative practices. Iterative tweaking and divergent thinking remain key to enabling creativity support using technology6,7, yet these practices are insufficiently supported by state-of-the-art generative AI m...
• Stronger and coarser-grained biodegradable zinc alloys AI翻译
  作者：Wu, Chengcheng; Lin, Fengxiang; Liu, Hong; Pelletier, Matthew H.; Lloyd, Max; Walsh, Williams R.; Nie, Jian-Feng
  作者单位：Monash University; Karlstad University; Shanghai Jiao Tong University; University of New South Wales Sydney
  摘要：Zinc is emerging as a key material for next-generation biodegradable implants1, 2, 3, 4-5. However, its inherent softness limits its use in load-bearing orthopaedic implants. Although reducing the grain size of zinc can make it stronger, it also destabilizes its mechanical properties and thus makes it less durable at body temperature6. Here we show that extruded Zn alloys of dilute compositions can achieve ultrahigh strength and excellent durability when their micron-scale grain size is increa...
• Here's how to bag a hefty research prize to turbocharge innovation AI翻译
  作者：Brazil, Rachel
• Don't overlook the mental-health costs of California's wildfires AI翻译
  作者：Mor-Ben-Ishai, Shir; Levin, Yafit; Ben-Ezra, Menachem
  作者单位：Ariel University
• External Li supply reshapes Li deficiency and lifetime limit of batteries AI翻译
  作者：Chen, Shu; Wu, Guanbin; Jiang, Haibo; Wang, Jifeng; Chen, Tiantian; Han, Chenyang; Wang, Wenwen; Yang, Rongchen; Zhao, Jiahua; Tang, Zhihang; Gong, Xiaocheng; Li, Chuanfa; Zhu, Mengyao; Zhang, Kun; Xu, Yifei; Wang, Ying; Hu, Zhe; Chen, Peining; Wang, Bingjie; Zhang, Kai; Xia, Yongyao; Peng, Huisheng; Gao, Yue
  作者单位：Fudan University; Fudan University; Nankai University; Hunan Institute of Engineering; Shenzhen University; Fudan University; Fudan University
  摘要：Lithium (Li) ions are central to the energy storing functionality of rechargeable batteries1. Present technology relies on sophisticated Li-inclusive electrode materials to provide Li ions and exactingly protect them to ensure a decent lifetime2. Li-deficient materials are thus excluded from battery design, and the battery fails when active Li ions are consumed3. Our study breaks this limit by means of a cell-level Li supply strategy. This involves externally adding an organic Li salt into an ...