8051期

最新文章

• Prolonged persistence of mutagenic DNA lesions in somatic cells AI翻译
  作者：Spencer Chapman, Michael; Mitchell, Emily; Yoshida, Kenichi; Williams, Nicholas; Fabre, Margarete A.; Ranzoni, Anna Maria; Robinson, Philip S.; Kregar, Lori D.; Wilk, Matthias; Boettcher, Steffen; Mahbubani, Krishnaa; Saeb Parsy, Kourosh; Gowers, Kate H. C.; Janes, Sam M.; Ng, Stanley W. K.; Hoare, Matt; Green, Anthony R.; Vassiliou, George S.; Cvejic, Ana; Manz, Markus G.; Laurenti, Elisa; Martincorena, Inigo; Stratton, Michael R.; Nangalia, Jyoti; Coorens, Tim H. H.; Campbell, Peter J.
  作者单位：Wellcome Trust Sanger Institute; University of London; Queen Mary University London; University of Cambridge; University of Cambridge; AstraZeneca; University of Zurich; University of Zurich; University Zurich Hospital; University of Cambridge; University of Cambridge; University of London; University College London; University of Cambridge; University of Copenhagen; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：DNA is subject to continual damage, leaving each cell with thousands of individual DNA lesions at any given moment1, 2-3. The efficiency of DNA repair means that most known classes of lesion have a half-life of minutes to hours3,4, but the extent to which DNA damage can persist for longer durations remains unknown. Here, using high-resolution phylogenetic trees from 89 donors, we identified mutations arising from 818 DNA lesions that persisted across multiple cell cycles in normal human stem c...
• These universities have the most retracted scientific articles AI翻译
  作者：Van Noorden, Richard
• Global meta-analysis shows action is needed to halt genetic diversity loss AI翻译
  作者：Shaw, Robyn E.; Farquharson, Katherine A.; Bruford, Michael W.; Coates, David J.; Elliott, Carole P.; Mergeay, Joachim; Ottewell, Kym M.; Segelbacher, Gernot; Hoban, Sean; Hvilsom, Christina; Perez-Espona, Silvia; Runis, Dainis; Aravanopoulos, Filippos; Bertola, Laura D.; Cotrim, Helena; Cox, Karen; Cubric-Curik, Vlatka; Ekblom, Robert; Godoy, Jose A.; Konopinski, Maciej K.; Laikre, Linda; Russo, Isa-Rita M.; Velickovic, Nevena; Vergeer, Philippine; Vila, Carles; Brajkovic, Vladimir; Field, David L.; Goodall-Copestake, William P.; Hailer, Frank; Hopley, Tara; Zachos, Frank E.; Alves, Paulo C.; Biedrzycka, Aleksandra; Binks, Rachel M.; Buiteveld, Joukje; Buzan, Elena; Byrne, Margaret; Huntley, Barton; Iacolina, Laura; Keehnen, Naomi L. P.; Klinga, Peter; Kopatz, Alexander; Kurland, Sara; Leonard, Jennifer A.; Manfrin, Chiara; Marchesini, Alexis; Millar, Melissa A.; Orozco-terWengel, Pablo; Ottenburghs, Jente; Posledovich, Diana; Spencer, Peter B.; Tourvas, Nikolaos; Unuk Nahberger, Tina; van Hooft, Pim; Verbylaite, Rita; Vernesi, Cristiano; Grueber, Catherine E.
  作者单位：Murdoch University; Australian National University; University of Canberra; University of Sydney; University of Sydney; Cardiff University; University of Western Australia; Research Institute for Nature & Forest; KU Leuven; University of Freiburg; University of Edinburgh; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Roslin Institute; University of Edinburgh; Latvian State Forest Research Institute Silava; Aristotle University of Thessaloniki; University of Copenhagen; Universidade de Lisboa; University of Zagreb; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); Polish Academy of Sciences; Stockholm University; University of Novi Sad; Wageningen University & Research; Macquarie University; Edith Cowan University; Chinese Academy of Sciences; Institute of Zoology, CAS; University of Vienna; University of the Free State; Charles Darwin University; Universidade do Porto; Universidade do Porto; Wageningen University & Research; University of Primorska; University of Sassari; Aalborg University; Swedish University of Agricultural Sciences; Technical University Zvolen; Czech University of Life Sciences Prague; Norwegian Institute Nature Research; Uppsala University; University of Trieste; Consiglio Nazionale delle Ricerche (CNR); Istituto di Ricerca sugli Ecosistemi Terrestri (IRET); National Biodiversity Future Center; Wageningen University & Research; Wageningen University & Research; Slovenian Forestry Institute; Fondazione Edmund Mach
  摘要：Mitigating loss of genetic diversity is a major global biodiversity challenge1, 2, 3-4. To meet recent international commitments to maintain genetic diversity within species5,6, we need to understand relationships between threats, conservation management and genetic diversity change. Here we conduct a global analysis of genetic diversity change via meta-analysis of all available temporal measures of genetic diversity from more than three decades of research. We show that within-population gene...
• Insufficient evidence for natural selection associated with the Black Death AI翻译
  作者：Vilgalys, Tauras P.; Klunk, Jennifer; Demeure, Christian E.; Cheng, Xiaoheng; Shiratori, Mari; Madej, Julien; Beau, Remi; Elli, Derek; Patino, Maria I.; Redfern, Rebecca; Dewitte, Sharon N.; Gamble, Julia A.; Boldsen, Jesper L.; Carmichael, Ann; Varlik, Nukhet; Eaton, Katherine; Grenier, Jean-Christophe; Golding, G. Brian; Devault, Alison; Rouillard, Jean-Marie; Yotova, Vania; Sindeaux, Renata; Ye, Chun Jimmie; Bikaran, Matin; Dumaine, Anne; Brinkworth, Jessica F.; Missiakas, Dominique; Rouleau, Guy A.; Steinrucken, Matthias; Pizarro-Cerda, Javier; Poinar, Hendrik N.; Barreiro, Luis B.
  作者单位：University of Chicago; McMaster University; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; University of Chicago; University of Chicago; University of South Carolina System; University of South Carolina Columbia; University of Manitoba; University of Southern Denmark; Indiana University System; Indiana University Bloomington; Rutgers University System; Rutgers University Newark; Rutgers University New Brunswick; Universite de Montreal; University of Michigan System; University of Michigan; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; McGill University; University of Chicago; McMaster University; Canadian Institute for Advanced Research (CIFAR); University of Chicago; University of Chicago
• RELMβ sets the threshold for microbiome-dependent oral tolerance AI翻译
  作者：Stephen-Victor, Emmanuel; Kuziel, Gavin A.; Martinez-Blanco, Monica; Jugder, Bat-Erdene; Benamar, Mehdi; Wang, Ziwei; Chen, Qian; Lozano, Gabriel L.; Abdel-Gadir, Azza; Cui, Ye; Fong, Jason; Saint-Denis, Elisa; Chang, Iris; Nadeau, Kari C.; Phipatanakul, Wanda; Zhang, Angela; Farraj, Farida Abi; Holder-Niles, Faye; Zeve, Daniel; Breault, David T.; Schmitz-Abe, Klaus; Rachid, Rima; Crestani, Elena; Rakoff-Nahoum, Seth; Chatila, Talal A.
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; AstraZeneca; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Stanford University; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; University of Miami; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：Tolerance to dietary antigens is critical for avoiding deleterious type 2 immune responses resulting in food allergy (FA) and anaphylaxis1,2. However, the mechanisms resulting in both the maintenance and failure of tolerance to food antigens are poorly understood. Here we demonstrate that the goblet-cell-derived resistin-like molecule beta (RELM beta)3,4 is a critical regulator of oral tolerance. RELM beta is abundant in the sera of both patients with FA and mouse models of FA. Deletion of REL...
• The secrets of static electricity are finally being revealed AI翻译
  作者：Lacks, Daniel J.; Sow, Mamadou
  作者单位：University System of Ohio; Case Western Reserve University
• Charles Darwin saw the importance of development in evolution AI翻译
  作者：Liu, Yongsheng
  作者单位：Henan Institute of Science & Technology
• Women need platforms to celebrate excellence in research and technology AI翻译
  作者：[Anonymous]
• Shielding Pt/γ-Mo2N by inert nano-overlays enables stable H2 production AI翻译
  作者：Gao, Zirui; Li, Aowen; Liu, Xingwu; Peng, Mi; Yu, Shixiang; Wang, Maolin; Ge, Yuzhen; Li, Chengyu; Wang, Tie; Wang, Zhaohua; Zhou, Wu; Ma, Ding
  作者单位：Peking University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：The use of reactive supports to disperse metal species is crucial for constructing highly efficient interfacial catalysts, by tuning the competitive reactant adsorption-activation pattern in supported metal catalysts into a non-competitive mechanism1, 2-3. However, these reactive supports are prone to deterioration during catalysis, limiting the lifespan of the catalyst and their potential practical applications4. New strategies are needed to simultaneously protect reactive supports and surfac...
• Designed endocytosis-inducing proteins degrade targets and amplify signals AI翻译
  作者：Huang, Buwei; Abedi, Mohamad; Ahn, Green; Coventry, Brian; Sappington, Isaac; Tang, Cong; Wang, Rong; Schlichthaerle, Thomas; Zhang, Jason Z.; Wang, Yujia; Goreshnik, Inna; Chiu, Ching Wen; Chazin-Gray, Adam; Chan, Sidney; Gerben, Stacey; Murray, Analisa; Wang, Shunzhi; O'Neill, Jason; Yi, Li; Yeh, Ronald; Misquith, Ayesha; Wolf, Anitra; Tomasovic, Luke M.; Piraner, Dan I.; Duran Gonzalez, Maria J.; Bennett, Nathaniel R.; Venkatesh, Preetham; Ahlrichs, Maggie; Dobbins, Craig; Yang, Wei; Wang, Xinru; Sahtoe, Danny D.; Vafeados, Dionne; Mout, Rubul; Shivaei, Shirin; Cao, Longxing; Carter, Lauren; Stewart, Lance; Spangler, Jamie B.; Roybal, Kole T.; Greisen, Per, Jr.; Li, Xiaochun; Bernardes, Goncalo J. L.; Bertozzi, Carolyn R.; Baker, David
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Stanford University; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; Universidade de Lisboa; University of Texas System; University of Texas Southwestern Medical Center; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; University of California System; University of California San Francisco; Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Harvard University; Harvard Medical School; California Institute of Technology; Westlake University; University of Cambridge; Howard Hughes Medical Institute; Stanford University
  摘要：Endocytosis and lysosomal trafficking of cell surface receptors can be triggered by endogenous ligands. Therapeutic approaches such as lysosome-targeting chimaeras1,2 (LYTACs) and cytokine receptor-targeting chimeras3 (KineTACs) have used this to target specific proteins for degradation by fusing modified native ligands to target binding proteins. Although powerful, these approaches can be limited by competition with native ligands and requirements for chemical modification that limit genetic ...