8051期

最新文章

• Ancient human genomes offer clues about the earliest migrations out of Africa AI翻译
  作者：Martinon-Torres, Maria; Lalueza-Fox, Carles
  作者单位：Centro Nacional de Investigacion de La Evolucion Humana (CENIEH)
• Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia (vol 637, pg 412, 2025) AI翻译
  作者：Swingle, Kelsey L.; Hamilton, Alex G.; Safford, Hannah C.; Geisler, Hannah C.; Thatte, Ajay S.; Palanki, Rohan; Murray, Amanda M.; Han, Emily L.; Mukalel, Alvin J.; Han, Xuexiang; Joseph, Ryann A.; Ghalsasi, Aditi A.; Alameh, Mohamad-Gabriel; Weissman, Drew; Mitchell, Michael J.
• Conserving global genetic diversity of species AI翻译
  作者：Nogues-Bravo, David; Rahbek, Carsten
  作者单位：University of Copenhagen; University of Copenhagen; University of Southern Denmark
• 'Talking won't save the planet': uniting efforts to save Panama's parks AI翻译
  作者：Hedley, Esme
• FBP1 controls liver cancer evolution from senescent MASH hepatocytes (vol 637, pg 461, 2025) AI翻译
  作者：Gu, Li; Zhu, Yahui; Nandi, Shuvro P.; Lee, Maiya; Watari, Kosuke; Bareng, Breanna; Ohira, Masafumi; Liu, Yuxiao; Sakane, Sadatsugu; Carlessi, Rodrigo; Sauceda, Consuelo; Dhar, Debanjan; Ganguly, Souradipta; Hosseini, Mojgan; Teneche, Marcos G.; Adams, Peter D.; Gonzalez, David J.; Kisseleva, Tatiana; Tirnitz-Parker, Janina E. E.; Simon, M. Celeste; Alexandrov, Ludmil B.; Karin, Michael; Liver Cancer Collaborative, Benjamin J.
• From farm to pharmacy: gene-edited plants produce a popular supplement AI翻译
  作者：[Anonymous]
• Episodic and associative memory from spatial scaffolds in the hippocampus AI翻译
  作者：Chandra, Sarthak; Sharma, Sugandha; Chaudhuri, Rishidev; Fiete, Ila
  作者单位：Massachusetts Institute of Technology (MIT); University of California System; University of California Davis; University of California System; University of California Davis
  摘要：Hippocampal circuits in the brain enable two distinct cognitive functions: the construction of spatial maps for navigation, and the storage of sequential episodic memories1, 2, 3, 4-5. Although there have been advances in modelling spatial representations in the hippocampus6, 7, 8, 9-10, we lack good models of its role in episodic memory. Here we present a neocortical-entorhinal-hippocampal network model that implements a high-capacity general associative memory, spatial memory and episodic me...
• Money and murder: the dark side of the Asilomar meeting on recombinant DNA AI翻译
  作者：Cobb, Matthew
• Transferrin receptor targeting chimeras for membrane protein degradation AI翻译
  作者：Zhang, Dingpeng; Duque-Jimenez, Jhoely; Facchinetti, Francesco; Brixi, Garyk; Rhee, Kaitlin; Feng, William W.; Janne, Pasi A.; Zhou, Xin
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
  摘要：Cancer cells require high levels of iron for rapid proliferation, leading to significant upregulation of cell-surface transferrin receptor 1 (TfR1), which mediates iron uptake by binding to the iron-carrying protein transferrin1-3. Leveraging this phenomenon and the fast endocytosis rate of TfR1 (refs. 4,5), we developed transferrin receptor targeting chimeras (TransTACs), a heterobispecific antibody modality for membrane protein degradation. TransTACs are engineered to drive rapid co-internal...
• Federico Mayor Zaragoza(1934-2024) AI翻译
  作者：Avila, Jesus; Mayor Jr, Federico; Bovolenta, Paola