8053期

最新文章

• Behind every great woman in science, there's another great woman in science AI翻译
  作者：Heidt, Amanda
• CD45-PET is a robust, non-invasive tool for imaging inflammation AI翻译
  作者：Farid, Ali Salehi; Rowley, Jennifer E.; Allen, Harris H.; Kruger, Isabella G.; Tavakolpour, Soheil; Neeley, Kyle; Cong, Min; Shahbazian, Haneyeh; Dorafshani, Niki; Berrada, Achraf; Macdonagh, Alexander C.; Padera, Robert F.; Brugarolas, Pedro; Packard, Alan B.; Rosenbaum, Matthew W.; Divakaran, Sanjay; Di Carli, Marcelo F.; Rashidian, Mohammad
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School
  摘要：Imaging inflammation holds immense potential for advancing the diagnosis, treatment and prognosis of many conditions1, 2-3. The lack of a specific and sensitive positron emission tomography (PET) probe to detect inflammation is a critical challenge. To bridge this gap, we present CD45-PET imaging, which detects inflammation with exceptional sensitivity and clarity in several preclinical models. Notably, the intensity of the CD45-PET signal correlates robustly with the severity of disease in mo...
• Hippocampal neuronal activity is aligned with action plans AI翻译
  作者：Zutshi, Ipshita; Apostolelli, Athina; Yang, Wannan; Zheng, Zheyang Sam; Dohi, Tora; Balzani, Edoardo; Williams, Alex H.; Savin, Cristina; Buzsaki, Gyorgy
  作者单位：New York University; New York University; New York University; Simons Foundation; Flatiron Institute
  摘要：Neurons in the hippocampus are correlated with different variables, including space, time, sensory cues, rewards and actions, in which the extent of tuning depends on ongoing task demands1, 2, 3, 4, 5, 6, 7-8. However, it remains uncertain whether such diverse tuning corresponds to distinct functions within the hippocampal network or whether a more generic computation can account for these observations9. Here, to disentangle the contribution of externally driven cues versus internal computatio...
• AI must be taught concepts, not just patterns in raw data AI翻译
  作者：Chaudhri, Vinay K.
• Against the odds: 12 women who beat bias to succeed in science AI翻译
  作者：Ferry, Georgina
• FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions (vol 632, pg 1165, 2024) AI翻译
  作者：Alcon, Pablo; Kaczmarczyk, Artur P.; Ray, Korak Kumar; Liolios, Themistoklis; Guilbaud, Guillaume; Sijacki, Tamara; Shen, Yichao; Mclaughlin, Stephen H.; Sale, Julian E.; Knipscheer, Puck; Rueda, David S.; Passmore, Lori A.
• Human echolocation can be taught AI翻译
  作者：Makin, Simon
• Amazonian deforestation makes the wet season wetter, and the dry season dryer AI翻译
  作者：Thiery, Wim
  作者单位：Vrije Universiteit Brussel
• Impact of Amazonian deforestation on precipitation reverses between seasons AI翻译
  作者：Qin, Yingzuo; Wang, Dashan; Ziegler, Alan D.; Fu, Bojie; Zeng, Zhenzhong
  作者单位：Southern University of Science & Technology; Maejo University; Chinese Academy of Sciences
  摘要：Tropical deforestation was found to cause large reductions in precipitation using a range of observation-based datasets1. However, the limitations of satellite-based space-for-time statistical analysis have hindered understanding of the roles of reshaped mesoscale atmospheric circulation and regional precipitation recycling at different scales. These effects are considered nonlocal effects, which are distinct from the local effects governed by deforestation-induced reductions in evapotranspira...
• Structural insights into RNA cleavage by PIWI Argonaute AI翻译
  作者：Li, Zhiqing; Xu, Qikui; Zhong, Jing; Zhang, Yan; Zhang, Tianxiang; Ying, Xiaoze; Lu, Xiaoli; Li, Xiaoyi; Wan, Li; Xue, Junchao; Huang, Jing; Zhen, Ying; Zhang, Zhao; Wu, Jianping; Shen, En-Zhi
  作者单位：Westlake University; Westlake Laboratory; Westlake University; Westlake University; Duke University
  摘要：Argonaute proteins are categorized into AGO and PIWI clades. Across most animal species, AGO-clade proteins are widely expressed in various cell types, and regulate normal gene expression1. By contrast, PIWI-clade proteins predominantly function during gametogenesis to suppress transposons and ensure fertility1,2. Both clades use nucleic acid guides for target recognition by means of base pairing, crucial for initiating target silencing, often through direct cleavage. AGO-clade proteins use a ...