CD45-PET is a robust, non-invasive tool for imaging inflammation

• 成果类型: Article
• 署名作者: Farid, Ali Salehi; Rowley, Jennifer E.; Allen, Harris H.; Kruger, Isabella G.; Tavakolpour, Soheil; Neeley, Kyle; Cong, Min; Shahbazian, Haneyeh; Dorafshani, Niki; Berrada, Achraf; Macdonagh, Alexander C.; Padera, Robert F.; Brugarolas, Pedro; Packard, Alan B.; Rosenbaum, Matthew W.; Divakaran, Sanjay; Di Carli, Marcelo F.; Rashidian, Mohammad
• 署名单位: Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School
• 刊物名称: Nature
• ISSN/ISSBN: 0028-2197
• DOI: 10.1038/s41586-024-08441-6
• 发表日期: 2025-03-06
• 关键词: disease; f-18-fdg; cancer; antibodies; biopsy; injury

摘要

Imaging inflammation holds immense potential for advancing the diagnosis, treatment and prognosis of many conditions1, 2-3. The lack of a specific and sensitive positron emission tomography (PET) probe to detect inflammation is a critical challenge. To bridge this gap, we present CD45-PET imaging, which detects inflammation with exceptional sensitivity and clarity in several preclinical models. Notably, the intensity of the CD45-PET signal correlates robustly with the severity of disease in models of inflammatory lung and bowel diseases, outperforming 18F-fluorodeoxyglucose PET, the most widely used imaging modality for inflammation globally. Longitudinal CD45-PET imaging further enables precise monitoring of dynamic changes in tissue-specific inflammatory profiles. Finally, we developed a human CD45-PET probe for clinical translation that effectively detects human immune cells in a humanized mouse model. CD45-PET imaging holds substantial clinical promise, offering a tool for guiding diagnostic and therapeutic decisions for inflammatory diseases through a precise, whole-body assessment of the inflammation profiles of individual patients.