8060期

最新文章

• Roses are red - but their ancestors were yellow AI翻译
  作者：[Anonymous]
• Ultra-broadband optical amplification using nonlinear integrated waveguides AI翻译
  作者：Zhao, Ping; Shekhawat, Vijay; Girardi, Marcello; He, Zonglong; Torres-Company, Victor; Andrekson, Peter A.
  作者单位：Chalmers University of Technology; Sichuan University
  摘要：Four-wave mixing is a nonlinear optical phenomenon that can be used for wideband low-noise optical amplification and wavelength conversion. It has been extensively investigated for applications in communications1, computing2, metrology3, imaging4 and quantum optics5. With its advantages of small footprint, large nonlinearity and dispersion-engineering capability, optical integrated waveguides are excellent candidates for realizing high-gain and large-bandwidth four-wave mixing for which anomal...
• How Trump 2.0 is slashing NIH-backed research - in charts AI翻译
  作者：Kozlov, Max; Ryan, Chris
• Europe must become a research epicentre as US system gets undermined AI翻译
  作者：Rubartelli, Anna; Poli, Valeria; Mattaj, Iain; Sitia, Roberto
  作者单位：University of Genoa; IRCCS AOU San Martino IST; University of Turin; Human Technopole; Vita-Salute San Raffaele University
• VDAC2 loss elicits tumour destruction and inflammation for cancer therapy AI翻译
  作者：Yuan, Sujing; Sun, Renqiang; Shi, Hao; Chapman, Nicole M.; Hu, Haoran; Guy, Cliff; Rankin, Sherri; Kc, Anil; Palacios, Gustavo; Meng, Xiaoxi; Sun, Xiang; Zhou, Peipei; Yang, Xiaoyang; Gottschalk, Stephen; Chi, Hongbo
  作者单位：St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital
  摘要：Tumour cells often evade immune pressure exerted by CD8+ T cells or immunotherapies through mechanisms that are largely unclear1,2. Here, using complementary in vivo and in vitro CRISPR-Cas9 genetic screens to target metabolic factors, we established voltage-dependent anion channel 2 (VDAC2) as an immune signal-dependent checkpoint that curtails interferon-gamma (IFN gamma)-mediated tumour destruction and inflammatory reprogramming of the tumour microenvironment. Targeting VDAC2 in tumour cell...
• A wetter ancient Arabia AI翻译
  作者：Bibi, Faysal
  作者单位：Leibniz Institut fur Evolutions und Biodiversitatsforschung
• A robustly rooted tree of eukaryotes reveals their excavate ancestry AI翻译
  作者：Williamson, Kelsey; Eme, Laura; Banos, Hector; Mccarthy, Charley G. P.; Susko, Edward; Kamikawa, Ryoma; Orr, Russell J. S.; Munoz-Gomez, Sergio A.; Minh, Bui Quang; Simpson, Alastair G. B.; Roger, Andrew J.
  作者单位：Dalhousie University; Dalhousie University; Universite Paris Saclay; University of Rhode Island; Dalhousie University; California State University System; California State University San Bernardino; Kyoto University; University of Oslo; Norwegian Defence Research Establishment; Purdue University System; Purdue University; Australian National University; Dalhousie University
  摘要：The eukaryote Tree of Life (eToL) depicts the relationships among all eukaryotic organisms; its root represents the Last Eukaryotic Common Ancestor (LECA) from which all extant complex lifeforms are descended1. Locating this root is crucial for reconstructing the features of LECA, both as the endpoint of eukaryogenesis and the start point for the evolution of the myriad complex traits underpinning the diversification of living eukaryotes. However, the position of the root remains contentious d...
• Why politicians manipulate statistics - and what to do about it AI翻译
  作者：Forsberg, Ole J.
  摘要：Understanding the playbook that those in power use to twist numbers, and how they make others complicit, is only becoming more important in the post-truth world.
• mRNA technology helps reinvigorate the hunt for cancer vaccines AI翻译
  作者：Nogrady, Bianca
• Modular chiral origami metamaterials AI翻译
  作者：Zhao, Tuo; Dang, Xiangxin; Manos, Konstantinos; Zang, Shixi; Mandal, Jyotirmoy; Chen, Minjie; Paulino, Glaucio H.
  作者单位：Princeton University; Princeton University; Princeton University; Princeton University
  摘要：Metamaterials with multimodal deformation mechanisms resemble machines1,2, especially when endowed with autonomous functionality. A representative architected assembly, with tunable chirality, converts linear motion into rotation3. These chiral metamaterials with a machine-like dual modality have potential use in areas such as wave manipulation4, optical activity related to circular polarization5 and chiral active fluids6. However, the dual motions are essentially coupled and cannot be indepen...