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作者：Thiel, Vera; Renders, Simon; Panten, Jasper; Dross, Nicolas; Bauer, Katharina; Azorin, Daniel; Henriques, Vanessa; Vogel, Vanessa; Klein, Corinna; Leppae, Aino-Maija; Ortega, Isabel Barriuso; Schwickert, Jonas; Ourailidis, Iordanis; Mochayedi, Julian; Mallm, Jan-Philipp; Mueller-Tidow, Carsten; Monyer, Hannah; Neoptolemos, John; Hackert, Thilo; Stegle, Oliver; Odom, Duncan T.; Offringa, Rienk; Stenzinger, Albrecht; Winkler, Frank; Sprick, Martin; Trumpp, Andreas
作者单位：Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Nikon Corporation; Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; National Center for Tumor Diseases
摘要：The peripheral nervous system (PNS) orchestrates organ function in health and disease. Most cancers, including pancreatic ductal adenocarcinoma (PDAC), are infiltrated by PNS neurons, and this contributes to the complex tumour microenvironment (TME)1,2. However, neuronal cell bodies reside in various PNS ganglia, far from the tumour mass. Thus, cancer-innervating or healthy-organ-innervating neurons are lacking in current tissue-sequencing datasets. To molecularly characterize pancreas- and PD...
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作者：Witze, Alexandra; Garisto, Dan; Tollefson, Jeff
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作者：Wiegand, Thorsten; Wang, Xugao; Fischer, Samuel M.; Kraft, Nathan J. B.; Bourg, Norman A.; Brockelman, Warren Y.; Cao, Guanghong; Cao, Min; Chanthorn, Wirong; Chu, Chengjin; Davies, Stuart; Ediriweera, Sisira; Gunatilleke, C. V. Savitri; Gunatilleke, I. A. U. Nimal; Hao, Zhanqing; Howe, Robert; Jiang, Mingxi; Jin, Guangze; Kress, W. John; Li, Buhang; Lian, Juyu; Lin, Luxiang; Liu, Feng; Ma, Keping; Mcshea, William; Mi, Xiangcheng; Myers, Jonathan A.; Nathalang, Anuttara; Orwig, David A.; Shen, Guochun; Su, Sheng-Hsin; Sun, I-Fang; Wang, Xihua; Wolf, Amy; Yan, Enrong; Ye, Wanhui; Zhu, Yan; Huth, Andreas
作者单位：Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Chinese Academy of Sciences; Shenyang Institute of Applied Ecology, CAS; University of California System; University of California Los Angeles; Smithsonian Institution; Smithsonian National Zoological Park & Conservation Biology Institute; National Science & Technology Development Agency - Thailand; Chinese Academy of Sciences; Xishuangbanna Tropical Botanical Garden, CAS; Kasetsart University; Sun Yat Sen University; Smithsonian Institution; Smithsonian Tropical Research Institute; Uva Wellassa University; University of Peradeniya; Northwestern Polytechnical University; University of Wisconsin System; Chinese Academy of Sciences; Wuhan Botanical Garden, CAS; Northeast Forestry University - China; Smithsonian Institution; Smithsonian National Museum of Natural History; Chinese Academy of Sciences; South China Botanical Garden, CAS; Chinese Academy of Sciences; Institute of Botany, CAS; Washington University (WUSTL); Harvard University; East China Normal University; National Dong Hwa University; University Osnabruck
摘要：The search for simple principles that underlie the spatial structure and dynamics of plant communities is a long-standing challenge in ecology1, 2, 3, 4, 5-6. In particular, the relationship between species coexistence and the spatial distribution of plants is challenging to resolve in species-rich communities7, 8-9. Here we present a comprehensive analysis of the spatial patterns of 720 tree species in 21 large forest plots and their consequences for species coexistence. We show that species ...
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作者：Rosenke, Kyle; Griffin, Amanda; Kaiser, Franziska; Altynova, Ekaterina; Mukesh, Reshma; Bushmaker, Trenton; Flagg, Meaghan; Tipih, Thomas; Goldin, Kerry; Wickenhagen, Arthur; Williamson, Brandi N.; Gallogly, Shane; Leventhal, Shanna S.; Lutterman, Tessa; Okumura, Atsushi; Lewis, Matthew C.; Kanakabandi, Kishore; Martens, Craig; Yinda, Kwe C.; Rao, Deepashri; Smith, Brian J.; Shaia, Carl; Saturday, Greg; Hanley, Patrick; van Doremalen, Neeltje; de Wit, Emmie; Munster, Vincent J.; Feldmann, Heinz
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
摘要：Since early 2022, highly pathogenic avian influenza (HPAI) H5N1 virus infections have been reported in wild aquatic birds and poultry throughout the USA with spillover into several mammalian species1, 2, 3, 4, 5-6. In March 2024, HPAIV H5N1 clade 2.3.4.4b was first detected in dairy cows in Texas, USA, and continues to circulate on dairy farms in many states7,8. Milk production and quality are diminished in infected dairy cows, with high virus titres in milk raising concerns of exposure to mam...
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作者：[Anonymous]
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作者：Chen, Huihuang; Qi, Linlin; Zou, Minxia; Lu, Mengting; Kwiatkowski, Mateusz; Pei, Yuanrong; Jaworski, Krzysztof; Friml, Jiri
作者单位：Institute of Science & Technology - Austria; Shenzhen University of Advanced Technology; Shenzhen University of Advanced Technology; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Nicolaus Copernicus University
摘要：The phytohormone auxin (Aux) is a principal endogenous developmental signal in plants. It mediates transcriptional reprogramming by a well-established canonical signalling mechanism. TIR1/AFB auxin receptors are F-box subunits of an ubiquitin ligase complex; after auxin perception, they associate with Aux/IAA transcriptional repressors and ubiquitinate them for degradation, thus enabling the activation of auxin response factor (ARF) transcription factors1, 2-3. Here we revise this paradigm by ...
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作者：Callahan, Christopher W.; Mankin, Justin S.
作者单位：Dartmouth College; Dartmouth College; Dartmouth College; Columbia University
摘要：Will it ever be possible to sue anyone for damaging the climate? Twenty years after this question was first posed, we argue that the scientific case for climate liability is closed. Here we detail the scientific and legal implications of an 'end-to-end' attribution that links fossil fuel producers to specific damages from warming. Using scope 1 and 3 emissions data from major fossil fuel companies, peer-reviewed attribution methods and advances in empirical climate economics, we illustrate the...
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作者：Sharma, Pranav
作者单位：Department of Science & Technology (India); Raman Research Institute (RRI)
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作者：Jangra, Manoj; Travin, Dmitrii Y.; Aleksandrova, Elena V.; Kaur, Manpreet; Darwish, Lena; Koteva, Kalinka; Klepacki, Dorota; Wang, Wenliang; Tiffany, Maya; Sokaribo, Akosiererem; Coombes, Brian K.; Vazquez-Laslop, Nora; Polikanov, Yury S.; Mankin, Alexander S.; Wright, Gerard D.
作者单位：McMaster University; McMaster University; McMaster University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital
摘要：Lasso peptides (biologically active molecules with a distinct structurally constrained knotted fold) are natural products that belong to the class of ribosomally synthesized and post-translationally modified peptides1, 2-3. Lasso peptides act on several bacterial targets4,5, but none have been reported to inhibit the ribosome, one of the main targets of antibiotics in the bacterial cell6,7. Here we report the identification and characterization of the lasso peptide antibiotic lariocidin and it...
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作者：Eisenstein, Michael
