-
作者：Kogevinas, Manolis; Pollarolo, Giulia; Barouki, Robert
作者单位：ISGlobal; Institut National de la Sante et de la Recherche Medicale (Inserm)
-
作者：[Anonymous]
-
作者：Fielden, John; Siegner, Sebastian M.; Gallagher, Danielle N.; Schroder, Markus S.; Dello Stritto, Maria Rosaria; Lam, Simon; Kobel, Lena; Schlapansky, Moritz F.; Jackson, Stephen P.; Cejka, Petr; Jost, Marco; Corn, Jacob E.
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Universita della Svizzera Italiana; CRUK Cambridge Institute; Cancer Research UK; University of Cambridge; University of Cambridge; University of Cambridge; Harvard University; Harvard Medical School
摘要：The DNA damage response (DDR) is a multifaceted network of pathways that preserves genome stability1,2. Unravelling the complementary interplay between these pathways remains a challenge3,4. Here we used CRISPR interference (CRISPRi) screening to comprehensively map the genetic interactions required for survival during normal human cell homeostasis across all core DDR genes. We captured known interactions and discovered myriad new connections that are available online. We defined the molecular...
-
作者：Cui, Xiekui; Yang, Han; Cai, Charles; Beaman, Cooper; Yang, Xiaoyu; Liu, Hongjiang; Ren, Xingjie; Amador, Zachary; Jones, Ian R.; Keough, Kathleen C.; Zhang, Meng; Fair, Tyler; Abnousi, Armen; Mishra, Shreya; Ye, Zhen; Hu, Ming; Pollen, Alex A.; Pollard, Katherine S.; Shen, Yin
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Cleveland Clinic Foundation; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI); University of California System; University of California San Francisco
摘要：Human accelerated regions (HARs) are conserved genomic loci that have experienced rapid nucleotide substitutions following the divergence from chimpanzees1,2. HARs are enriched in candidate regulatory regions near neurodevelopmental genes, suggesting their roles in gene regulation3. However, their target genes and functional contributions to human brain development remain largely uncharacterized. Here we elucidate the cis-regulatory functions of HARs in human and chimpanzee induced pluripotent...
-
作者：Plackett, Benjamin
-
作者：Markowska, Monika; Vonhof, Hubert B.; Groucutt, Huw S.; Breeze, Paul S.; Drake, Nick; Stewart, Mathew; Albert, Richard; Andrieux, Eric; Blinkhorn, James; Boivin, Nicole; Budsky, Alexander; Clark-Wilson, Richard; Fleitmann, Dominik; Gerdes, Axel; Martin, Ashley N.; Martinez-Garcia, Alfredo; Nicholson, Samuel L.; Price, Gilbert J.; Scerri, Eleanor M. L.; Scholz, Denis; Vanwezer, Nils; Weber, Michael; Alsharekh, Abdullah M.; Al Omari, Abdul Aziz; Al-Mufarreh, Yahya S. A.; Al-Jibreen, Faisal; Alqahtani, Mesfer; Al-Shanti, Mahmoud; Zalmout, Iyad; Petraglia, Michael D.; Haug, Gerald H.
作者单位：Max Planck Society; Northumbria University; University of Malta; University of Cologne; University of London; King's College London; Griffith University; Goethe University Frankfurt; Durham University; Max Planck Society; University of Liverpool; Max Planck Society; University of Queensland; Griffith University; University of London; Royal Holloway University London; University of Basel; Leibniz University Hannover; University of Queensland; Johannes Gutenberg University of Mainz; King Saud University; Saudi Geological Survey; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Saudi Geological Survey; University of Michigan System; University of Michigan; Smithsonian Institution; Smithsonian National Museum of Natural History; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：The Saharo-Arabian Desert is one of the largest biogeographical barriers on Earth, impeding dispersals between Africa and Eurasia, including movements of past hominins. Recent research suggests that this barrier has been in place since at least 11 million years ago1. In contrast, fossil evidence from the late Miocene epoch and the Pleistocene epoch suggests the episodic presence within the Saharo-Arabian Desert interior of water-dependent fauna (for example, crocodiles, equids, hippopotamids a...
-
作者：Perelli, Luigi; Zhang, Li; Mangiameli, Sarah; Giannese, Francesca; Mahadevan, Krishnan K.; Peng, Fuduan; Citron, Francesca; Khan, Hania; Le, Courtney; Gurreri, Enrico; Carbone, Federica; Russell, Andrew J. C.; Soeung, Melinda; Lam, Truong Nguyen Anh; Lundgren, Sebastian; Marisetty, Sujay; Zhu, Cihui; Catania, Desiree; Mohamed, Alaa M. T.; Feng, Ningping; Augustine, Jithesh Jose; Sgambato, Alessandro; Tortora, Giampaolo; Draetta, Giulio F.; Tonon, Giovanni; Futreal, Andrew; Giuliani, Virginia; Carugo, Alessandro; Viale, Andrea; Kim, Michael P.; Heffernan, Timothy P.; Wang, Linghua; Kalluri, Raghu; Cittaro, Davide; Chen, Fei; Genovese, Giannicola
作者单位：University of Texas System; UTMD Anderson Cancer Center; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Nerviano Medical Sciences S.r.l; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Merck & Company; Merck & Company Italy; University of Texas System; UTMD Anderson Cancer Center; Rice University; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center
摘要：Mesenchymal plasticity has been extensively described in advanced epithelial cancers; however, its functional role in malignant progression is controversial1, 2, 3, 4-5. The function of epithelial-to-mesenchymal transition (EMT) and cell plasticity in tumour heterogeneity and clonal evolution is poorly understood. Here we clarify the contribution of EMT to malignant progression in pancreatic cancer. We used somatic mosaic genome engineering technologies to trace and ablate malignant mesenchyma...
-
作者：Wu, Bo; Crew, Bec; Maxwell, Tanner
-
作者：[Anonymous]
