8060期

最新文章

• Which programming language should I use? A guide for early-career researchers AI翻译
  作者：Perkel, Jeffrey M.
• Liquids in a glass recover a graceful shape even after being shaken AI翻译
  作者：[Anonymous]
• A sharp volatile-rich cap to the Yellowstone magmatic system AI翻译
  作者：Duan, Chenglong; Song, Wenkai; Schmandt, Brandon; Farrell, Jamie; Lumley, David; Fischer, Tobias; Worthington, Lindsay Lowe; Lin, Fan-Chi
  作者单位：University of New Mexico; Rice University; Utah System of Higher Education; University of Utah; University of Texas System; University of Texas Dallas; University of Texas System; University of Texas Dallas
  摘要：The stability of hazardous volcanic systems is strongly influenced by the uppermost magma storage depth and volatile exsolution1, 2-3. Despite abundant evidence for an upper crustal magma reservoir beneath Yellowstone caldera4, 5, 6-7, its depth and the properties at its top have not been well constrained. New controlled-source seismic imaging illuminates a sharp reflective cap of the magma reservoir approximately 3.8 km beneath the northeastern caldera. Magma ascent to such low pressure is ex...
• Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia AI翻译
  作者：Kamizela, Aleksandra E.; Leongamornlert, Daniel; Williams, Nicholas; Wang, Xin; Nyamondo, Kudzai; Dawson, Kevin; Chapman, Michael Spencer; Guo, Jing; Lee, Joe; Mane, Karim; Milne, Kate; Green, Anthony R.; Chevassut, Timothy; Campbell, Peter J.; Ellinor, Patrick T.; Huntly, Brian J. P.; Baxter, E. Joanna; Nangalia, Jyoti
  作者单位：Wellcome Trust Sanger Institute; University of Cambridge; University of Cambridge; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of London; Queen Mary University London; University of Sussex; University of Brighton; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
  摘要：Mutation of some genes drives uncontrolled cell proliferation and cancer. The Philadelphia chromosome in chronic myeloid leukaemia (CML) provided the very first such genetic link to cancer1,2. However, little is known about the trajectory to CML, the rate of BCR::ABL1 clonal expansion and how this affects disease. Using whole-genome sequencing of 1,013 haematopoietic colonies from nine patients with CML aged 22 to 81 years, we reconstruct phylogenetic trees of haematopoiesis. Intronic breaks i...
• BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments AI翻译
  作者：Lahiri, Sudipta; Hamilton, George; Moore, Gemma; Goehring, Liana; Huang, Tony T.; Jensen, Ryan B.; Rothenberg, Eli
  作者单位：New York University; Yale University
  摘要：The tumour-suppressor protein BRCA2 has a central role in homology-directed DNA repair by enhancing the formation of RAD51 filaments on resected single-stranded DNA generated at double-stranded DNA breaks and stimulating RAD51 activity1,2. Individuals with BRCA2 mutations are predisposed to cancer; however, BRCA2-deficient tumours are often responsive to targeted therapy with PARP inhibitors (PARPi)3, 4, 5-6. The mechanism by which BRCA2 deficiency renders cells sensitive to PARPi but with min...
• Pinpointing neurons that hinder cancer treatment AI翻译
  作者：Demir, Ihsan Ekin; Demir, Elke
  作者单位：Technical University of Munich; Technical University of Munich; Acibadem University; University of Southern Denmark
• Arctic researchers need to find ways to keep working together AI翻译
  作者：Christensen, Torben R.
  作者单位：Aarhus University; University of Oulu
• Radical approach to shrink particle colliders gains momentum AI翻译
  作者：Gibney, Elizabeth
• Print, melt, repeat: 3D-printing formula yields sturdy objects time after time AI翻译
  作者：[Anonymous]
• Programs, origins and immunomodulatory functions of myeloid cells in glioma AI翻译
  作者：Miller, Tyler E.; El Farran, Chadi A.; Couturier, Charles P.; Chen, Zeyu; D'Antonio, Joshua P.; Verga, Julia; Villanueva, Martin A.; Castro, L. Nicolas Gonzalez; Tong, Yuzhou Evelyn; Saadi, Tariq Al; Chiocca, Andrew N.; Zhang, Yuanyuan; Fischer, David S.; Heiland, Dieter Henrik; Guerriero, Jennifer L.; Petrecca, Kevin; Suva, Mario L.; Shalek, Alex K.; Bernstein, Bradley E.
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Ragon Institute; Harvard University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; McGill University; University of Freiburg; Northwestern University; Feinberg School of Medicine; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; McGill University
  摘要：Gliomas are incurable malignancies notable for having an immunosuppressive microenvironment with abundant myeloid cells, the immunomodulatory phenotypes of which remain poorly defined1. Here we systematically investigate these phenotypes by integrating single-cell RNA sequencing, chromatin accessibility, spatial transcriptomics and glioma organoid explant systems. We discovered four immunomodulatory expression programs: microglial inflammatory and scavenger immunosuppressive programs, which ar...