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作者：[Anonymous]
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作者：Chung, Elizabeth N.; Lee, Jinsu; Polonio, Carolina M.; Choi, Joshua; Akl, Camilo Faust; Kilian, Michael; Weiss, Wiebke M.; Gunner, Georgia; Ye, Mingyu; Heo, Tae Hyun; Drake, Sienna S.; Yang, Liu; d'Eca, Catarina R. G. L.; Lee, Joon-Hyuk; Deng, Liwen; Farrenkopf, Daniel; Schuele, Anton M.; Lee, Hong-Gyun; Afolabi, Oreoluwa; Ghaznavi, Sharmin; Smirnakis, Stelios M.; Chiu, Isaac M.; Kuchroo, Vijay K.; Quintana, Francisco J.; Wheeler, Michael A.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Neuroimmune interactions-signals transmitted between immune and brain cells-regulate many aspects of tissue physiology1, including responses to psychological stress2, 3, 4-5, which can predispose individuals to develop neuropsychiatric diseases6, 7, 8-9. Still, the interactions between haematopoietic and brain-resident cells that influence complex behaviours are poorly understood. Here, we use a combination of genomic and behavioural screens to show that astrocytes in the amygdala limit stress...
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作者：Chen, Chien-Wen; Papadopoli, David; Szkop, Krzysztof J.; Guan, Bo-Jhih; Alzahrani, Mohammed; Wu, Jing; Jobava, Raul; Asraf, Mais M.; Krokowski, Dawid; Vourekas, Anastasios; Merrick, William C.; Komar, Anton A.; Koromilas, Antonis E.; Gorospe, Myriam; Payea, Matthew J.; Wang, Fangfang; Clayton, Benjamin L. L.; Tesar, Paul J.; Schaffer, Ashleigh; Miron, Alexander; Bederman, Ilya; Jankowsky, Eckhard; Vogel, Christine; Valasek, Leos Shivaya; Dinman, Jonathan D.; Zhang, Youwei; Tirosh, Boaz; Larsson, Ola; Topisirovic, Ivan; Hatzoglou, Maria
作者单位：University System of Ohio; Case Western Reserve University; Lady Davis Institute; Jewish General Hospital - Montreal; McGill University; Karolinska Institutet; University System of Ohio; Case Western Reserve University; King Saud Bin Abdulaziz University for Health Sciences; Yale University; Maria Curie-Sklodowska University; Louisiana State University System; Louisiana State University; University System of Ohio; Cleveland State University; McGill University; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; New York University; Czech Academy of Sciences; Institute of Microbiology of the Czech Academy of Sciences; University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland Baltimore; Universities at Shady Grove; McGill University
摘要：An increased level of phosphorylation of eukaryotic translation initiation factor 2 subunit-alpha (eIF2 alpha, encoded by EIF2S1; eIF2 alpha-p) coupled with decreased guanine nucleotide exchange activity of eIF2B is a hallmark of the 'canonical' integrated stress response (c-ISR)1. It is unclear whether impaired eIF2B activity in human diseases including leukodystrophies2, which occurs in the absence of eIF2 alpha-p induction, is synonymous with the c-ISR. Here we describe a mechanism triggere...
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作者：Hou, Zhengyang; Zhang, Liqiang; Peng, Jingjing; Forzieri, Giovanni; Jia, Aolin; Xiao, Zhiqiang; Qu, Ying; Lin, Jintai; Ji, Duoying; Zhu, Zidong; Yao, Xin; Peng, Shuwen; Zhao, Lanpu; Fan, Wenjie; Wu, Zhaocong; Geng, Hao; Wang, Qihao; Zhou, Chenghu; Liu, Suhong; Zhang, Liangpei
作者单位：Beijing Normal University; Henan Academy of Sciences; University System of Maryland; University of Maryland College Park; University of Florence; Luxembourg Institute of Science & Technology; Peking University; Peking University; Peking University; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS
摘要：Surface albedo greatly affects how much energy the Earth absorbs. Intensive human activities and accelerated climate change have altered surface albedo across spatial and temporal scales(1, 2-3), yet assessments of the effects of land use or land cover (LULC) and snow variations on land surface albedo are scarce at the global scale. As a result, the global land surface albedo dynamics over recent decades and their corresponding radiative forcing to the climate system remain poorly understood(4...
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作者：Ledford, Heidi
摘要：Immune-cell function improved in a teenager whose DNA was altered using prime editing.
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作者：Willyard, Cassandra
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作者：Audard, Marc; Awaki, Hisamitsu; Ballhausen, Ralf; Bamba, Aya; Behar, Ehud; Boissay-Malaquin, Rozenn; Brenneman, Laura; Brown, Gregory V.; Corrales, Lia; Costantini, Elisa; Cumbee, Renata; Trigo, Maria Diaz; Done, Chris; Dotani, Tadayasu; Ebisawa, Ken; Eckart, Megan; Eckert, Dominique; Enoto, Teruaki; Eguchi, Satoshi; Ezoe, Yuichiro; Foster, Adam; Fujimoto, Ryuichi; Fujita, Yutaka; Fukazawa, Yasushi; Fukushima, Kotaro; Furuzawa, Akihiro; Gallo, Luigi; Garcia, Javier A.; Gu, Liyi; Guainazzi, Matteo; Hagino, Kouichi; Hamaguchi, Kenji; Hatsukade, Isamu; Hayashi, Katsuhiro; Hayashi, Takayuki; Hell, Natalie; Hodges-Kluck, Edmund; Hornschemeier, Ann; Ichinohe, Yuto; Ishida, Manabu; Ishikawa, Kumi; Ishisaki, Yoshitaka; Kaastra, Jelle; Kallman, Timothy; Kara, Erin; Katsuda, Satoru; Kanemaru, Yoshiaki; Kelley, Richard; Kilbourne, Caroline; Kitamoto, Shunji; Kobayashi, Shogo; Kohmura, Takayoshi; Kubota, Aya; Leutenegger, Maurice; Loewenstein, Michael; Maeda, Yoshitomo; Markevitch, Maxim; Matsumoto, Hironori; Matsushita, Kyoko; Mccammon, Dan; Mcnamara, Brian; Mernier, Francois; Miller, Eric D.; Miller, Jon M.; Mitsuishi, Ikuyuki; Mizumoto, Misaki; Mizuno, Tsunefumi; Mori, Koji; Mukai, Koji; Murakami, Hiroshi; Mushotzky, Richard; Nakajima, Hiroshi; Nakazawa, Kazuhiro; Ness, Jan-Uwe; Nobukawa, Kumiko; Nobukawa, Masayoshi; Noda, Hirofumi; Odaka, Hirokazu; Ogawa, Shoji; Ogorzalek, Anna; Okajima, Takashi; Ota, Naomi; Paltani, Stephane; Petre, Robert; Plucinsky, Paul; Porter, Frederick Scott; Pottschmidt, Katja; Sato, Kosuke; Sato, Toshiki; Sawada, Makoto; Seta, Hiromi; Shidatsu, Megumi; Simionescu, Aurora; Smith, Randall; Suzuki, Hiromasa; Szymkowiak, Andrew; Takahashi, Hiromitsu; Takeo, Mai; Tamagawa, Toru; Tamura, Keisuke; Tanaka, Takaaki; Tanimoto, Atsushi; Tashiro, Makoto; Terada, Yukikatsu; Terashima, Yuichi; Tsuboi, Yohko; Tsujimoto, Masahiro; Tsunemi, Hiroshi; Tsuru, Takeshi G.; Uchida, Hiroyuki; Uchida, Nagomi; Uchida, Yuusuke; Uchiyama, Hideki; Ueda, Yoshihiro; Uno, Shinichiro; Vink, Jacco; Watanabe, Shin; Williams, Brian J.; Yamada, Satoshi; Yamada, Shinya; Yamaguchi, Hiroya; Yamaoka, Kazutaka; Yamasaki, Noriko; Yamauchi, Makoto; Yamauchi, Shigeo; Yaqoob, Tahir; Yoneyama, Tomokage; Yoshida, Tessei; Yukita, Mihoko; Zhuravleva, Irina; Braito, Valentina; Condo, Pierpaolo; Fukumura, Keigo; Gonzalez, Adam; Luminari, Alfredo; Miyamoto, Aiko; Mizukawa, Ryuki; Reeves, James; Sato, Riki; Tombesi, Francesco; Xu, Yerong
作者单位：University of Geneva; Ehime University; University System of Maryland; University of Maryland College Park; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University of Tokyo; Technion Israel Institute of Technology; Massachusetts Institute of Technology (MIT); University System of Maryland; University of Maryland Baltimore County; Smithsonian Institution; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; University of Michigan System; University of Michigan; Durham University; University of Tokyo; Japan Aerospace Exploration Agency (JAXA); Institute of Space & Astronautical Science (ISAS); Kyoto University; Tokyo Metropolitan University; Hiroshima University; Fujita Health University; Saint Marys University - Canada; California Institute of Technology; European Space Agency; European Space Research & Technology Centre; University of Miyazaki; RIKEN; Leiden University; Leiden University - Excl LUMC; Saitama University; Rikkyo University; Tokyo University of Science; Tokyo University of Science; Shibaura Institute of Technology; University of Osaka; University of Wisconsin System; University of Wisconsin Madison; University of Waterloo; Nagoya University; Hiroshima University; Tohoku Gakuin University; Kanto Gakuin University; European Space Agency; European Space Astronomy Center; Kindai University (Kinki University); Nara University Education; Tohoku University; Nara Womens University; Kyoto Sangyo University; Meiji University; Yale University; Konan University; Kagoshima University; Chuo University; Shizuoka University; Kyoto University; University of Amsterdam; Johns Hopkins University; University of Chicago; Istituto Nazionale Astrofisica (INAF); Catholic University of America; University of Trento; University of Rome Tor Vergata; James Madison University; Istituto Nazionale Astrofisica (INAF); Istituto Nazionale Astrofisica (INAF)
摘要：Evidence indicates that supermassive black holes (SMBHs) exist at the centres of most galaxies. Their mass correlates with the galactic bulge mass1, suggesting a coevolution with their host galaxies2, most likely through powerful winds3. X-ray observations have detected highly ionized winds outflowing at sub-relativistic speeds from the accretion disks around SMBHs4,5. However, the limited spectral resolution of present X-ray instruments has left the physical structure and location of the wind...
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作者：Castelvecchi, Davide
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作者：Hatzikotoulas, Konstantinos; Southam, Lorraine; Stefansdottir, Lilja; Boer, Cindy G.; Mcdonald, Merry-Lynn; Pett, J. Patrick; Park, Young-Chan; Tuerlings, Margo; Mulders, Rick; Barysenka, Andrei; Arruda, Ana Luiza; Tragante, Vinicius; Rocco, Alison; Bittner, Norbert; Chen, Shibo; Horn, Susanne; Srinivasasainagendra, Vinodh; To, Ken; Katsoula, Georgia; Kreitmaier, Peter; Tenghe, Amabel M. M.; Gilly, Arthur; Arbeeva, Liubov; Chen, Lane G.; de Pins, Agathe M.; Dochtermann, Daniel; Henkel, Cecilie; Hoeijer, Jonas; Ito, Shuji; Lind, Penelope A.; Lukusa-Sawalena, Bitota; Minn, Aye Ko Ko; Mola-Caminal, Marina; Narita, Akira; Nguyen, Chelsea; Reimann, Ene; Silberstein, Micah D.; Skogholt, Anne-Heidi; Tiwari, Hemant K.; Yau, Michelle S.; Yue, Ming; Zhao, Wei; Zhou, Jin J.; Alexiadis, George; Banasik, Karina; Brunak, Soren; Campbell, Archie; Cheung, Jackson T. S.; Dowsett, Joseph; Faquih, Tariq; Faul, Jessica D.; Fei, Lijiang; Fenstad, Anne Marie; Funayama, Takamitsu; Gabrielsen, Maiken E.; Gocho, Chinatsu; Gromov, Kirill; Hansen, Thomas; Hudjashov, Georgi; Ingvarsson, Thorvaldur; Johnson, Jessica S.; Jonsson, Helgi; Kakehi, Saori; Karjalainen, Juha; Kasbohm, Elisa; Lemmelae, Susanna; Lin, Kuang; Liu, Xiaoxi; Loef, Marieke; Mangino, Massimo; Mccartney, Daniel; Millwood, Iona Y.; Richman, Joshua; Roberts, Mary B.; Ryan, Kathleen A.; Samartzis, Dino; Shivakumar, Manu; Skou, Soren T.; Sugimoto, Sachiyo; Suzuki, Ken; Takuwa, Hiroshi; Teder-Laving, Maris; Thomas, Laurent; Tomizuka, Kohei; Turman, Constance; Weiss, Stefan; Wu, Tian T.; Zengini, Eleni; Zhang, Yanfei; Babis, George; van Heel, David A.; Winsvold, Bendik; Gabrielsen, Maiken; Ferreira, Manuel Allen Revez; Baras, Aris; Barker, Tyler; Carey, David J.; Cheah, Kathryn S. E.; Chen, Zhengming; Cheung, Jason Pui-Yin; Daly, Mark; de Mutsert, Renee; Eaton, Charles B.; Erikstrup, Christian; Furnes, Ove Nord; Golightly, Yvonne M.; Gudbjartsson, Daniel F.; Hailer, Nils P.; Hayward, Caroline; Hochberg, Marc C.; Homuth, Georg; Huckins, Laura M.; Hveem, Kristian; Ikegawa, Shiro; Ishijima, Muneaki; Isomura, Minoru; Jones, Marcus; Kang, Jae H.; Kardia, Sharon L. R.; Kloppenburg, Margreet; Kraft, Peter; Kumahashi, Nobuyuki; Kuwata, Suguru; Lee, Ming Ta Michael; Lee, Phil H.; Lerner, Robin; Li, Liming; Lietman, Steve A.; Lotta, Luca; Lupton, Michelle K.; Maegi, Reedik; Martin, Nicholas G.; Mcalindon, Timothy E.; Medland, Sarah E.; Michaelsson, Karl; Mitchell, Braxton D.; Mook-Kanamori, Dennis O.; Morris, Andrew P.; Nabika, Toru; Nagami, Fuji; Nelson, Amanda E.; Ostrowski, Sisse Rye; Palotie, Aarno; Pedersen, Ole Birger; Rosendaal, Frits R.; Sakurai-Yageta, Mika; Schmidt, Carsten Oliver; Sham, Pak Chung; Singh, Jasvinder A.; Smelser, Diane T.; Smith, Jennifer A.; Song, You-qiang; Sorensen, Erik; Tamiya, Gen; Tamura, Yoshifumi; Terao, Chikashi; Thorleifsson, Gudmar; Troelsen, Anders; Tsezou, Aspasia; Uchio, Yuji; Uitterlinden, A. G.; Ullum, Henrik; Valdes, Ana M.; Walters, Robin G.; Weir, David R.; Wilkinson, J. Mark; Winsvold, Bendik S.; Yamamoto, Masayuki; Zwart, John-Anker; Stefansson, Kari; Meulenbelt, Ingrid; Teichmann, Sarah A.; van Meurs, Joyce B. J.; Styrkarsdottir, Unnur; Zeggini, Eleftheria
作者单位：Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Decode Genetics; Erasmus University Rotterdam; Erasmus MC; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; Wellcome Trust Sanger Institute; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); University of Alabama System; University of Alabama Birmingham; University of Cambridge; University of Cambridge; Eberhard Karls University of Tubingen; Regeneron; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Hong Kong; Icahn School of Medicine at Mount Sinai; University of Copenhagen; Uppsala University; Shimane University; RIKEN; RIKEN; QIMR Berghofer Medical Research Institute; University of Queensland; Queensland University of Technology (QUT); Tohoku University; Tohoku University; University of Tartu; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Norwegian University of Science & Technology (NTNU); Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Hebrew SeniorLife; University of Hong Kong; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of California System; University of California Los Angeles; University of Copenhagen; University of Edinburgh; Imperial College London; Rigshospitalet; University of Copenhagen; Copenhagen University Hospital; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; University of Bergen; Haukeland University Hospital; University of Copenhagen; University of Iceland; Icahn School of Medicine at Mount Sinai; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Juntendo University; University of Helsinki; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Universitat Greifswald; Greifswald Medical School; University of Oxford; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; University of London; King's College London; University of Alabama System; University of Alabama Birmingham; Brown University; University System of Maryland; University of Maryland Baltimore; University of Hong Kong; Rush University; University of Pennsylvania; University of Southern Denmark; Naestved Hospital; University of Manchester; University of Tokyo; University of Osaka; Norwegian University of Science & Technology (NTNU); Harvard University; Harvard T.H. Chan School of Public Health; Universitat Greifswald; Greifswald Medical School; Geisinger Health System; National & Kapodistrian University of Athens; University System of Ohio; Ohio State University; Utah System of Higher Education; University of Utah; Brown University; Brown University; Aarhus University; Aarhus University; University of Bergen; University of Nebraska System; University of Nebraska Medical Center; University of Iceland; Uppsala University; University of Edinburgh; University System of Maryland; University of Maryland Baltimore; Yale University; Norwegian University of Science & Technology (NTNU); Juntendo University; Shimane University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; University of London; Queen Mary University London; Peking University; Peking University; QIMR Berghofer Medical Research Institute; Queensland University of Technology (QUT); QIMR Berghofer Medical Research Institute; Tufts Medical Center; University of Queensland; University of Queensland; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Shimane University; University of Copenhagen; University of Hong Kong; University of Alabama System; University of Alabama Birmingham; Baylor College of Medicine; RIKEN; Juntendo University; Shizuoka General Hospital; University of Shizuoka; University of Copenhagen; University of Thessaly; Statens Serum Institut; University of Nottingham; University of Sheffield; University of Oslo; University of Oslo; University of Oslo; University of Cambridge; Technical University of Munich
摘要：Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes1. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide2. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent ...
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作者：Finkbeiner, Ann
