8065期

最新文章

• Multi-zonal liver organoids from human pluripotent stem cells AI翻译
  作者：Al Reza, Hasan; Santangelo, Connie; Iwasawa, Kentaro; Al Reza, Abid; Sekiya, Sachiko; Glaser, Kathryn; Bondoc, Alexander; Merola, Jonathan; Takebe, Takanori
  作者单位：Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; University of Osaka; University of Osaka; Yokohama City University
  摘要：Distinct hepatocyte subpopulations are spatially segregated along the portal-central axis and are critical to understanding metabolic homeostasis and injury in the liver1. Although several bioactive molecules, including ascorbate and bilirubin, have been described as having a role in directing zonal fates, zonal liver architecture has not yet been replicated in vitro2,3. Here, to evaluate hepatic zonal polarity, we developed a self-assembling zone-specific liver organoid by co-culturing ascorb...
• Constitutively active glucagon receptor drives high blood glucose in birds AI翻译
  作者：Zhang, Chang; Xiang, Xiangying; Liu, Jian; Huang, Yongjie; Xue, Jingwen; Sun, Qian; Leng, Song; Liu, Shaobo; He, Xuefei; Hu, Peng; Zhan, Xiangjiang; Qiu, Qiang; Yang, Shilong; Brosius, Juergen; Deng, Cheng
  作者单位：Sichuan University; Nanjing Normal University; Shanghai Ocean University; Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Sciences; Institute of Zoology, CAS; Northwestern Polytechnical University; Northeast Forestry University - China
  摘要：The maintenance of blood glucose, the body's primary source of energy, is indispensable for overall health and metabolic homeostasis. It is regulated predominantly by the glucagon receptor family which is highly conserved in vertebrates1, 2, 3-4. Compared with other vertebrates, avian blood glucose levels are relatively high5,6, and blood glucose regulatory mechanisms in birds have remained unclear. Here we show that high hepatic expression of the avian glucagon receptor (GCGR) in association ...
• How and when North America's deepest river gorge formed AI翻译
  作者：Mitchinson, Andrew
  摘要：An analysis of landscape features and of river deposits preserved in caves point to an event 2.1 million years ago that triggered the formation of Hells Canyon.
• Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning (vol 504, pg 272, 2013) AI翻译
  作者：Donato, Flavio; Rompani, Santiago Belluco; Caroni, Pico
• MFSD6 is an entry receptor for enterovirus D68 AI翻译
  作者：Varanese, Lauren; Xu, Lily; Peters, Christine E.; Pintilie, Grigore; Roberts, David S.; Raj, Suyash; Liu, Mengying; Ooi, Yaw Shin; Diep, Jonathan; Qiao, Wenjie; Richards, Christopher M.; Callaway, Jeremy; Bertozzi, Carolyn R.; Jabs, Sabrina; de Vries, Erik; van Kuppeveld, Frank J. M.; Nagamine, Claude M.; Chiu, Wah; Carette, Jan E.
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Utrecht University; National University of Singapore; Howard Hughes Medical Institute; Stanford University; University of Kiel; Schleswig Holstein University Hospital; Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory
  摘要：With the near eradication of poliovirus due to global vaccination campaigns, attention has shifted to other enteroviruses that can cause polio-like paralysis syndrome (now termed acute flaccid myelitis)1, 2-3. In particular, enterovirus D68 (EV-D68) is believed to be the main driver of epidemic outbreaks of acute flaccid myelitis in recent years4, yet not much is known about EV-D68 host interactions. EV-D68 is a respiratory virus5 but, in rare cases, can spread to the central nervous system to...
• Address academic bullying through structural reform AI翻译
  作者：Bell, Steven
  作者单位：University of Cambridge
• The forest space age needs eyes on the ground AI翻译
  作者：Phillips, Oliver; Duque, Alvaro; Rodriguez, Lillian; Zo-Bi, Irie Casimir
  作者单位：University of Leeds; Universidad Nacional de Colombia; University of the Philippines System; University of the Philippines Manila; Institut National Polytechnique Felix Houphouet-Boigny
• Explosive volcanoes can bury carbon -a climate boon AI翻译
  作者：[Anonymous]
• Stress dynamically modulates neuronal autophagy to gate depression onset (vol 641, pg 427, 2025) AI翻译
  作者：Yang, Liang; Guo, Chen; Zheng, Zhiwei; Dong, Yiyan; Xie, Qifeng; Lv, Zijian; Li, Min; Lu, Yangyang; Guo, Xiaonan; Deng, Rongshan; Liu, Yiqin; Feng, Yirong; Mu, Ruiqi; Zhang, Xuliang; Ma, Huan; Chen, Zhong; Zhang, Zhijun; Dong, Zhaoqi; Yang, Wei; Zhang, Xiangnan; Cui, Yihui
• AI linked to explosion of low-quality biomedical research papers AI翻译
  作者：Naddaf, Miryam
  摘要：Analysis flags hundreds of studies that seem to follow a template, reporting correlations between complex health conditions and single variables based on publicly available data sets.